(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID

Product Name: (1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID
CAS No.: 182485-36-5
Chemical Name: (1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID
Synonyms: TPMPA;tpmpa hydrate;MFUKVPOVVKKLRQ-UHFFFAOYSA-N;(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID;3,6-dihydro-2H-pyridin-1-ylium-4-yl(methyl)phosphinate;Phosphinic acid, P-methyl-P-(1,2,3,6-tetrahydro-4-pyridinyl)-;(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID HYDRATE
CBNumber: CB2285096
Molecular Formula: C6H12NO2P
Formula Weight: 161.14
MOL File: 182485-36-5.mol

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(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID Property

Melting point:: 252-254°
Boiling point:: 417.2±45.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: H₂O: 16 mg/mL
form: solid
pka: 1.97±0.20(Predicted)
color: white or off-white
Water Solubility: Soluble to 100 mM in water

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T200
Product name: (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate
Purity: ≥97% (NMR), solid
Packaging: 10mg
Price: $286
Updated: 2024/03/01

Sigma-Aldrich

Product number: T200
Product name: (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate
Purity: ≥97% (NMR), solid
Packaging: 50mg
Price: $800
Updated: 2024/03/01

Cayman Chemical

Product number: 24302
Product name: TPMPA
Purity: ≥95%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 24302
Product name: TPMPA
Purity: ≥95%
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 24302
Product name: TPMPA
Purity: ≥95%
Packaging: 10mg
Price: $188
Updated: 2024/03/01

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(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID Chemical Properties,Usage,Production

Uses

TPMPA is a selective, competitive GABAC antagonist with only minimal effects on GABAA and GABAB receptor.

Uses

(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate has also been used as γ-aminobutyric acid C (GABAc) blocker in retinal ganglion cells.

Uses

Neurochemical tool.

Biological Activity

A selective, competitive GABA C antagonist with only minimal effects on GABA A and GABA B receptors (K b values are 2.1 μ M (antagonist), 320 μ M (antagonist) and EC 50 ~ 500 μ M (weak agonist) respectively). Displays 8-fold selectivity for human recombinant ρ 1 receptors over ρ 2 receptors.

Biochem/physiol Actions

TPMPA is a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABAC receptors but not to interact with GABAA or GABAB receptors. Electrical assays show that TPMPA is a competitive antagonist of cloned human mu 1 GABAC receptors expressed in Xenopus laevis oocytes (Kb approx. 2 μM). TPMPA is >100-fold weaker as an inhibitor of rat brain GABAA receptors expressed in oocytes (Kb approx. 320 μM) and has only weak agonist activity on GABAB receptors assayed in rat hippocampal slices (EC50 approx. 500 μM). TPMPA may be used to investigate GABAC receptor function in the outer retina and in any other areas of the nervous system in which these types of receptor are present.

storage

Store at RT

(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID Suppliers

China 22 Germany 2 India 1 Switzerland 1 United Kingdom 2 United States 8 USA 1 Global 37

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182485-36-5, (1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACIDRelated Search:

3-AMINOPROPYL(METHYL)PHOSPHINIC ACID HCL (1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID

TPMPA

(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID

(1,2,5,6-TETRAHYDROPYRIDIN-4-YL)METHYLPHOSPHINIC ACID HYDRATE

tpmpa hydrate

MFUKVPOVVKKLRQ-UHFFFAOYSA-N

3,6-dihydro-2H-pyridin-1-ylium-4-yl(methyl)phosphinate

Phosphinic acid, P-methyl-P-(1,2,3,6-tetrahydro-4-pyridinyl)-

182485-36-5

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