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GEODIN

Product Name
GEODIN
CAS No.
427-63-4
Chemical Name
GEODIN
Synonyms
GEODIN;d-Geodin;(+)-ESTIN;(+)-Geodin;(+)-Form methyl ester;Geodin, PAI-1 (plasminogen activator inhibitor) inhibitor;methyl 5,7-dichloro-4-hydroxy-5'-methoxy-6-methyl-3,3'-dioxospiro[1-benzofuran-2,6'-cyclohexa-1,4-diene]-1'-carboxylate;methyl 5,7-dichloro-4-hydroxy-5'-methoxy-6-methyl-3,3'-dioxo-spiro[1-benzofuran-2,6'-cyclohexa-1,4-diene]-1'-carboxylate;5,7-dichloro-4-hydroxy-3,3'-diketo-5'-methoxy-6-methyl-spiro[benzofuran-2,6'-cyclohexa-1,4-diene]-1'-carboxylic acid methyl ester;SPIRO[BENZOFURAN-2(3H),1'-[2,5]CYCLOHEXADIENE]-2'-CARBOXYLIC ACID, 5,7-DICHLORO-4-HYDROXY-6'-METHOXY-6-METHYL-3,4'-DIOXO-, METHYL ESTER
CBNumber
CB2287449
Molecular Formula
C17H12Cl2O7
Formula Weight
399.18
MOL File
427-63-4.mol
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GEODIN Property

Melting point:
235℃
alpha 
D +140° (c = 0.8)
Boiling point:
652.1±55.0 °C(Predicted)
Density 
1.61±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Chloroform: soluble; DMSO: soluble; Ethyl Acetate: soluble; Methanol: soluble
form 
A solid
pka
5.17±0.60(Predicted)
color 
Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26421
Product name
(+)-Geodin
Packaging
1mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
26421
Product name
(+)-Geodin
Packaging
5mg
Price
$273
Updated
2024/03/01
TRC
Product number
G364603
Product name
Geodin
Packaging
2.5mg
Price
$165
Updated
2021/12/16
Usbiological
Product number
207211
Product name
Geodin
Packaging
1mg
Price
$346
Updated
2021/12/16
Adipogen Life Sciences
Product number
AG-CN2-0139-M005
Product name
Geodin
Purity
≥95%(HPLC)
Packaging
5mg
Price
$480
Updated
2021/12/16
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GEODIN Chemical Properties,Usage,Production

Description

(+)-Geodin is a fungal metabolite. It increases the fibrinolytic activity of bovine aortic endothelial cells (BAECs) when used at concentrations ranging from 50 to 150 μM. (+)-Geodin (1-100 μg/ml) also increases 2-deoxyglucose uptake by rat adipocytes.

Uses

Geodin is an inhibitor of plasminogen activator inhibitor (PAI-1).

storage

+4°C

References

[1] C SHINOHARA. Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B.[J]. Journal of Antibiotics, 2000, 53 3: 262-268. DOI: 10.7164/antibiotics.53.262
[2] SEIICHI SATO. Identification and Preliminary SAR Studies of (+)-Geodin as a Glucose Uptake Stimulator for Rat Adipocytes[J]. Journal of Antibiotics, 2005, 58 9: 583-589. DOI: 10.1038/ja.2005.79

GEODIN Preparation Products And Raw materials

Raw materials

Preparation Products

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GEODIN Suppliers

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427-63-4, GEODINRelated Search:

1-tert-Butoxy-4-chlorobenzene 3-(P-CHLOROPHENOXY)PROPIONIC ACID 5-CHLORO-BENZOFURAN-3-ONE 3,5-DIHYDROXY-4-ACETYLTOLUENE 5,7-DIFLUORO-BENZOFURAN-3-ONE 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE 1,4-Pentadien-3-ol 3-CHLOROPHENETHYLALCOHOL 5,7-DICHLORO-BENZOFURAN-3-ONE SS-19508B 2-HYDROXY-1-(4-METHYLPHENYL)ETHANONE METHYL 3-HYDROXY-2-METHYLENEBUTYRATE 2,4-dichloro-m-cresol 1-ALLYLOXY-2,4-DICHLORO-BENZENE SALOR-INT L497967-1EA 2,3-DIHYDRO-1-BENZOFURANACETIC ACID 2-(ALLYLOXY)-5-CHLOROBENZENECARBALDEHYDE 3-M-TOLYLOXY-PROPIONIC ACID

  • SPIRO[BENZOFURAN-2(3H),1'-[2,5]CYCLOHEXADIENE]-2'-CARBOXYLIC ACID, 5,7-DICHLORO-4-HYDROXY-6'-METHOXY-6-METHYL-3,4'-DIOXO-, METHYL ESTER
  • Estin, (+)-5,7-dichloro-4-hydroxy-6-methoxy-6-methyl-3,4-dioxo-spiro[benzofuran-2(3H),1-[2,5]cyclohexadiene]-2-carboxylic acid methyl ester
  • (1R)-3',4-Dioxo-4'-hydroxy-5',7'-dichloro-6-methoxy-6'-methylspiro[2,5-cyclohexadiene-1,2'(3'H)-benzofuran]-2-carboxylic acid methyl ester
  • (1R)-3',4-Dioxo-4'-hydroxy-5',7'-dichloro-6'-methyl-6-methoxyspiro[2,5-cyclohexadiene-1,2'(3'H)-benzofuran]-2-carboxylic acid methyl ester
  • (R)-5,7-Dichloro-4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxospiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic acid methyl ester
  • GEODIN
  • (+)-ESTIN
  • d-Geodin
  • 5,7-dichloro-4-hydroxy-3,3'-diketo-5'-methoxy-6-methyl-spiro[benzofuran-2,6'-cyclohexa-1,4-diene]-1'-carboxylic acid methyl ester
  • methyl 5,7-dichloro-4-hydroxy-5'-methoxy-6-methyl-3,3'-dioxo-spiro[1-benzofuran-2,6'-cyclohexa-1,4-diene]-1'-carboxylate
  • methyl 5,7-dichloro-4-hydroxy-5'-methoxy-6-methyl-3,3'-dioxospiro[1-benzofuran-2,6'-cyclohexa-1,4-diene]-1'-carboxylate
  • (1'R)-3,4'-Dioxo-5,7-dichloro-4-hydroxy-6'-methoxy-6-methyl-spiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic acid methyl ester
  • (+)-Form methyl ester
  • Spiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic acid, 5,7-dichloro-4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxo-, methyl ester, (1'R)-
  • (+)-Geodin
  • Geodin, PAI-1 (plasminogen activator inhibitor) inhibitor
  • 427-63-4
  • C17H12Cl2O7