troponin I type 3 (cardiac)
- Product Name
- troponin I type 3 (cardiac)
- CAS No.
- 339163-65-4
- Chemical Name
- troponin I type 3 (cardiac)
- Synonyms
- cTnI;RCM1;CMH7;CMD2A;CMD1FF;RCM 1 NEW;troponin I3;RCM-1 ，S6898;RCM-1, 10 mM in DMSO;Troponin I ELISA Kit
- CBNumber
- CB22914253
- Molecular Formula
- C20H12N2OS4
- Formula Weight
- 424.58
- MOL File
- 339163-65-4.mol
troponin I type 3 (cardiac) Property
- Boiling point:
- 632.8±55.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO : 16.67 mg/mL (39.26 mM)
- form
- buffered aqueous solution
- pka
- -1.42±0.37(Predicted)
- color
- Off-white to gray
- biological source
- mouse
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- WH0007137M4
- Product name
- Monoclonal Anti-TNNI3 antibody produced in mouse
- Purity
- clone 1E7, purified immunoglobulin, buffered aqueous solution
- Packaging
- 100μg
- Price
- $541
- Updated
- 2025/07/31
- Product number
- SAB2502170
- Product name
- Anti-TNNI3 antibody produced in goat
- Purity
- affinity isolated antibody, buffered aqueous solution
- Packaging
- 100μg
- Price
- $586
- Updated
- 2025/07/31
- Product number
- SAB5300191
- Product name
- Monoclonal Anti-TNNI3 antibody produced in mouse
- Purity
- clone 3A10A12, ascites fluid
- Packaging
- 100μL
- Price
- $503
- Updated
- 2023/01/07
- Product number
- 6845
- Product name
- RCM1
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 157173
- Product name
- Troponin I Type 3, Cardiac
- Packaging
- 10ug
- Price
- $327
- Updated
- 2021/12/16
troponin I type 3 (cardiac) Chemical Properties,Usage,Production
Uses
RCM-1 is a forkhead box M1 (FOXM1) inhibitor with an EC50 of 0.72 μM in U2OS cells. RCM-1 blocks the nuclear localization and increased the proteasomal degradation of FOXM1. RCM-1 can be used for asthma and other chronic airway diseases research[1].
General Description
Troponin I3, cardiac type (TNNI3), also known as cardiac troponin I (cTnI), is the inhibitory element of troponin. It possesses an inhibitory peptide (IP) domain and a switch peptide (SP) domain that is located N-terminal of the IP domain. The gene encoding TNNI3 is localized on human chromosome 19q13.42.
Biochem/physiol Actions
Troponin I3, cardiac type (TNNI3) or cardiac troponin I (cTnI) modulates the diastolic function of the heart. Low expression of TNNI3 is associated with cardiac diastolic dysfunction. Elevated expression of the protein indicates cardiac injury. TNNI3 is a biomarker for myocardial infarction and mutations in the gene encoding it have been linked to hypertrophic cardiomyopathy.
in vivo
RCM-1 reduces airway resistance, increased lung compliance, and decreased proinflammatory cytokine production in mice exposed to the house dust mite and interleukin-13 (IL-13), which triggers goblet cell metaplasia. In mice, RCM-1 reduces IL-13 and STAT6 signaling and prevented the expression of the STAT6 target genes Spdef and Foxa3[1].
storage
Store at -20°C
References
[1] Lifeng Sun, et al. The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Sci Signal. 2017 Apr 18;10(475):eaai8583. DOI:10.1126/scisignal.aai8583
troponin I type 3 (cardiac) Preparation Products And Raw materials
Raw materials
Preparation Products
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