N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE

Product Name: N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE
CAS No.: 188975-88-4
Chemical Name: N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE
Synonyms: tert-Butyl 4-oxoazepane-1-carboxylate;CAS:188975-88-4;BOC-AZEPAN-4-ONE;1-Boc-4-oxoazepane;1-BOC-4-AZEPANONE;CBNuMber: CB2294582;N-BOC-HEXAHYDRO-1H-A;4-Boc-hexahydroazepinone;1-Boc-homopiperazin-4-one;N-Boc-4-perhydroazepinone
CBNumber: CB2294582
Molecular Formula: C11H19NO3
Formula Weight: 213.27
MOL File: 188975-88-4.mol

More

Less

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE Property

Boiling point:: 90-1000C/0.5mmHg
Density: 1.072±0.06 g/cm3(Predicted)
refractive index: n20/D 1.467
storage temp.: 2-8°C
solubility: Soluble in Chloroform, Dichloromethane, Ethanol and Ethyl Ether.
pka: -1.50±0.20(Predicted)
form: Liquid or Low Melting Solid
color: Colorless to yellow
Sensitive: Air Sensitive
InChI: InChI=1S/C11H19NO3/c1-11(2,3)15-10(14)12-7-4-5-9(13)6-8-12/h4-8H2,1-3H3
InChIKey: PMLBUVZPRKXMOX-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCCC(=O)CC1
CAS DataBase Reference: 188975-88-4(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 29242990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 00833
Product name: N-Boc-hexahydro-1H-azepin-4-one
Purity: ≥95.0% (HPLC)
Packaging: 1G
Price: $301
Updated: 2023/06/20

Sigma-Aldrich

Product number: 00833
Product name: N-Boc-hexahydro-1H-azepin-4-one
Purity: ≥95.0% (HPLC)
Packaging: 5G
Price: $477
Updated: 2023/06/20

TCI Chemical

Product number: B3707
Product name: N-Boc-hexahydro-1H-azepin-4-one
Packaging: 5G
Price: $206
Updated: 2025/07/31

TRC

Product number: B621350
Product name: N-BocAzepan-4-one
Packaging: 5g
Price: $635
Updated: 2021/12/16

Oakwood

Product number: 046229
Product name: tert-butyl4-Oxoazepane-1-carboxylate
Purity: 95%
Packaging: 1g
Price: $14
Updated: 2021/12/16

More

Less

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE Chemical Properties,Usage,Production

Chemical Properties

Yellow Oil

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is a fine chemical intermediate.

Synthesis

141642-82-2

188975-88-4

General procedure for the synthesis of tert-butyl 4-oxoazepane-1-carboxylate from ethyl 1-Boc-5-oxoazepane-4-carboxylate: to a solution of 1-tert-butyl 5-oxoazepane-1,4-dicarboxylate (Compound 82.1, 19.0 g, 66.6 mmol) of 1,4-dioxane (190 mL) was added sodium hydroxide (4.00 g) dropwise , 100 mmol) to a solution of water (100 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the pH was adjusted to 4-5 with 3M aqueous hydrochloric acid solution and extracted with ethyl acetate (2 x 50 mL). The organic phases were combined, washed with brine (2 × 10 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1:3) as eluent to afford tert-butyl 4-oxoazepane-1-carboxylate (11 g, 77%) as a yellow oil.

References

[1] Patent: WO2004/35569, 2004, A2. Location in patent: Page/Page column 58
[2] Archiv der Pharmazie, 2013, vol. 346, # 3, p. 200 - 209
[3] Patent: WO2014/8197, 2014, A1. Location in patent: Page/Page column 151
[4] Patent: WO2015/95767, 2015, A1. Location in patent: Page/Page column 166
[5] Patent: WO2005/40169, 2005, A2. Location in patent: Page/Page column 84

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE Suppliers

Austria 1 Canada 1 China 246 France 2 Germany 1 India 7 Switzerland 1 Ukraine 1 United Kingdom 4 United States 27 Global 291

Mashilabs (Shanghai) Co.,Ltd.

Tel: 19916721580
Fax: QQ：3154870176
Email: mafarm@126.com
Country: China
ProdList: 4542
Advantage: 58

Suzhou Wenzhi Biotechnology Co., Ltd.

Tel: 13262848185
Email: 20840032@qq.com
Country: China
ProdList: 161
Advantage: 58

MINKESH (SHANGHAI) CO., LTD.

Tel: +86-021-20980300 +86-13167252998
Fax: 021-20983811
Email: sales@minkesh.com
Country: China
ProdList: 88
Advantage: 55

Shanghai Xchemtech Co., Ltd.

Tel: 17721086216
Email: 25522996@qq.com
Country: China
ProdList: 149
Advantage: 58

SiChuang NanBu Honesty Technology Co., Ltd.

Tel: 0838-5675166 15883665058
Fax: 0838-5675535
Email: nbcxkj@126.com
Country: China
ProdList: 918
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

More

Less

View Lastest Price from N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE 188975-88-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-10-28

Henan Aochuang Chemical Co.,Ltd.

Product: N-Boc-hexahydro-1H-azepin-4-one 188975-88-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Career Henan Chemical Co

Product: N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE 188975-88-4
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-08-05

188975-88-4, N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONERelated Search:

ETHANE tert-butyl 5-(2-((Methylsulfonyl)oxy)ethyl)isoindoline-2-carboxylate tert-butyl 5-propionyl-1H-pyrrolo[3,2-b]pyridine-1-carboxylate 4-Oxo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester N-BOC-5-FORMYLISOINDOLINE tert-butyl 4-oxotetrahydropyrimidine-1(2H)-carboxylate N-BOC-5-(HYDROXYMETHYL)-ISOINDOLINE ETHYL 1-BOC-5-OXO-HEXAHYDRO-1H-AZEPINE-4-CARBOXYLATE ETHYL 1-BOC-4-OXO-3-AZEPANECARBOXYLATE N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE Azepan-4-one 1-METHYLAZEPAN-4-ONE

N-Boc-4-perhydroazepinone

1H-Azepine-1-carboxylic acid

TERT-BUTYL-HEXAHYDRO-4-OXO-1H-AZEPINE-1-CARBOXYLATE

1-Boc-homopiperazin-4-one

N-Boc-hexahydro-1H-azepin-4-one ,96%

tert-Butyl 4-oxoazepane-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-oxoazepane

N-BOC-HEXAHYDRO-1H-A

1-(tert-Butoxycarbonyl)hexahydroazepin-4-one

1,1-DiMethylethyl 4-Oxohexahydro-1H-azepine-1-carboxylate

Hexahydro-4-oxo-1H-Azepine-1-carboxylic Acid 1,1-DiMethylethyl Ester

CBNuMber: CB2294582

N-Boc-4-oxo-azacycloheptane

1-Boc-4-oxoazepane

tert-Butyl 4-oxoazepane-1-carboxyl

Azepan-4-one, N-BOC protected 95%

1-(1,1-dimethylethoxycarbonyl)-1,2,3,5,6,7-hexahydroazepin-4-one

N-BOC-PERHYDROAZEPIN-4-ONE

N-BOC-HEXAHYDRO-1H-AZEPIN-4-ONE

1H-AZEPINE-1-CARBOXYLIC ACID, HEXAHYDRO-4-OXO-, 1,1-DIMETHYLETHYL ESTER

Azepan-4-one, N-BOC protected

tert-Butyl 4-oxoazepane-1-carboxylate

1-Boc-homopipoerazin-4-one

1-BOC-4-AZEPANONE

4-Boc-hexahydroazepinone

N-Boc-hexahydro-1H-azepine-4-one

4-OXOAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

BOC-AZEPAN-4-ONE

1-Boc-hexahydro-1H-azepin-4-one

4-N-Boc-hexahydroazepinone

1-Boc-homopiperazin-4-one, tert-Butyl hexahydro-4-oxo-1H-azepine-1-carboxylate

N-Boc-hexahydro-1H-azepin-4-one,98%

ert-butyl4-oxoazepane-1-carboxylate

CAS:188975-88-4

<i>N</i>-Boc-hexahydro-1<i>H</i>-azepin-4-one

188975-88-4

C11H19O3N

pharmacetical

Heterocycles series

Building Blocks/Intermediates

Heterocycles

Miscellaneous Reagents