2-(TRIMETHYLSILYLETHYNYL)PYRIDINE

Product Name: 2-(TRIMETHYLSILYLETHYNYL)PYRIDINE
CAS No.: 86521-05-3
Chemical Name: 2-(TRIMETHYLSILYLETHYNYL)PYRIDINE
Synonyms: TIMTEC-BB SBB009057;TriMethylsilylethynyl)pyridin;2-(Trimethylsilyethynyl)pyridine;(2-Pyridylethynyl)trimethylsilane;2-(TRIMETHYLSILYLETHYNYL)PYRIDINE;2-(Trimethlysilyl-ethynyl)pyridine;2-(Trimethylsilylethynyl)pyridine,97%;trimethyl(2-pyridin-2-ylethynyl)silane;Pyridine, 2-[2-(trimethylsilyl)ethynyl]-;Pyridine,2-[(trimethylsilyl)ethynyl]-(9CI)
CBNumber: CB2295453
Molecular Formula: C10H13NSi
Formula Weight: 175.3
MOL File: 86521-05-3.mol

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2-(TRIMETHYLSILYLETHYNYL)PYRIDINE Property

Melting point:: 42 °C
Boiling point:: 85 °C
Density: 0.95±0.1 g/cm3(Predicted)
refractive index: 1.5330
Flash point:: 85-86°C/1mm
storage temp.: Inert atmosphere,2-8°C
pka: 4.29±0.19(Predicted)
form: clear liquid
color: Colorless to Light orange to Yellow
Water Solubility: Insoluble in water.
BRN: 4176916
CAS DataBase Reference: 86521-05-3

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T3879
Product name: 2-[(Trimethylsilyl)ethynyl]pyridine
Packaging: 1G
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: T3879
Product name: 2-[(Trimethylsilyl)ethynyl]pyridine
Packaging: 5G
Price: $114
Updated: 2025/07/31

TRC

Product number: T896585
Product name: 2-(Trimethylsilylethynyl)pyridine
Packaging: 500mg
Price: $75
Updated: 2021/12/16

GFS CHEMICALS

Product number: 83422
Product name: 2-TMSETHYNYLPYRIDINE
Packaging: 25g
Price: $375.25
Updated: 2021/12/16

Synthonix

Product number: T53001
Product name: 2-((Trimethylsilyl)ethynyl)pyridine
Purity: 95+%
Packaging: 1g
Price: $30
Updated: 2021/12/16

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2-(TRIMETHYLSILYLETHYNYL)PYRIDINE Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to yellow liquid

Uses

2-(Trimethylsilylethynyl)pyridine is used as a pharmaceutical intermediate.

Synthesis

109-04-6

1066-54-2

86521-05-3

General procedure for the synthesis of 2-pyridinylalkynyltrimethylsilanes from 2-bromopyridine and trimethylsilylethynes: 100 mL of diisopropylamine solution containing 2-bromopyridine (4.74 g, 0.030 mol), CuI (0.14 g, 0.74 mmol), and Pd(PPh3)2Cl2 (0.52 g, 0.74 mmol) was added to a solution containing 2-bromopyridine (4.74 g, 0.030 mol), CuI (0.14 g, 0.74 mmol), and Pd(PPh3)2Cl2 (0.52 g, 0.74 mmol), protected by nitrogen. trimethylsilylacetylene (3.0 g, 0.030 mol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was purified to give 5.0 g (95% yield) of 2-(trimethylsilyl)ethynylpyridine.

References

[1] Synthesis, 1983, # 4, p. 312 - 314
[2] Canadian Journal of Chemistry, 2005, vol. 83, # 6-7, p. 716 - 727
[3] Phosphorus, Sulfur and Silicon and Related Elements, 2002, vol. 177, # 5, p. 1041 - 1045
[4] Patent: WO2006/93466, 2006, A1. Location in patent: Page/Page column 28
[5] Journal of Organometallic Chemistry, 2009, vol. 694, # 9-10, p. 1317 - 1324

2-(TRIMETHYLSILYLETHYNYL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(TRIMETHYLSILYLETHYNYL)PYRIDINE Suppliers

Belgium 1 China 58 Europe 1 France 1 Germany 3 India 4 Japan 1 United Kingdom 3 United States 16 Global 88

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View Lastest Price from 2-(TRIMETHYLSILYLETHYNYL)PYRIDINE manufacturers

Career Henan Chemical Co

Product: 2-(TRIMETHYLSILYLETHYNYL)PYRIDINE 86521-05-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-08

86521-05-3, 2-(TRIMETHYLSILYLETHYNYL)PYRIDINERelated Search:

3-(TRIMETHYLSILYLETHYNYL)PYRIDINE 4-(Trimethlysilyl-ethynyl)pyridine 2-[2-(TRIMETHYLSILYL)ETHYNYL]-4-PICOLINE 2-[2-(TRIMETHYLSILYL)ETHYNYL]-6-PICOLINE 2-[2-(TRIMETHYLSILYL)ETHYNYL]-5-PICOLINE 2,6-BIS(TRIMETHYLSILYLETHYNYL)PYRIDINE 4,6-DIMETHYL-2-TRIMETHYLSILANYLETHYNYL-NICOTINONITRILE 5-BROMO-2-[2-(TRIMETHYLSILYL)ETHYNYL]PYRIDINE 2-(TRIMETHYLSILYLETHYNYL)PYRIDINE 2-TRIMETHYLSILANYLETHYNYL-3-CYANOPYRIDINE 5-FLUORO-2-[2-(TRIMETHYLSILYL)ETHYNYL]PYRIDINE

TIMTEC-BB SBB009057

2-(TRIMETHYLSILYLETHYNYL)PYRIDINE

2-(Trimethylsilyethynyl)pyridine

Pyridine,2-[(trimethylsilyl)ethynyl]-(9CI)

2-(Trimethlysilyl-ethynyl)pyridine

2-(Trimethylsilylethynyl)pyridine,97%

TriMethylsilylethynyl)pyridin

2-(TRIMETHYLSILYLETHYNYL)PYRIDINE, 97%2-(TRIMETHYLSILYLETHYNYL)PYRIDINE, 97%2-(TRIMETHYLSILYLETHYNYL)PYRIDINE, 97%

Pyridine, 2-[2-(trimethylsilyl)ethynyl]-

(2-Pyridylethynyl)trimethylsilane

trimethyl(2-pyridin-2-ylethynyl)silane

2-((Trimethylsilyl)ethynyl)pyridine - [T53001]

86521-05-3

C5H4NCCSiCH33

SILYL