tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate

Product Name: tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate
CAS No.: 1029413-51-1
Chemical Name: tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate
Synonyms: 1-Boc-3-(4-amino-1-pyrazolyl)azetidine;tert-butyl 3-(4-aminopyrazol-1-yl)azetidine-1-carboxylate;tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate;1-Azetidinecarboxylic acid, 3-(4-amino-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester
CBNumber: CB23033362
Molecular Formula: C11H18N4O2
Formula Weight: 238.29
MOL File: 1029413-51-1.mol

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tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate Property

Boiling point:: 399.5±32.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 4.05±0.19(Predicted)
Appearance: Brown to reddish brown Liquid
InChI: InChI=1S/C11H18N4O2/c1-11(2,3)17-10(16)14-6-9(7-14)15-5-8(12)4-13-15/h4-5,9H,6-7,12H2,1-3H3
InChIKey: JYDHOTMQNGXWGO-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(N2C=C(N)C=N2)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A594035
Product name: 4-Amino-1-(1-boc-azetidin-3-yl)-1H-pyrazole
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0060915
Product name: tert-Butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate
Purity: >97.0%
Packaging: 1g
Price: $145
Updated: 2021/12/16

AK Scientific

Product number: 2738AQ
Product name: TERT-BUTYL3-(4-AMINO-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE
Packaging: 250mg
Price: $161.6
Updated: 2021/12/16

ChemScene

Product number: CS-0060915
Product name: tert-Butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate
Purity: >97.0%
Packaging: 250mg
Price: $58
Updated: 2021/12/16

ChemScene

Product number: CS-0060915
Product name: tert-Butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate
Purity: >97.0%
Packaging: 5g
Price: $418
Updated: 2021/12/16

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tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate Chemical Properties,Usage,Production

Uses

4-Amino-1-(1-boc-azetidin-3-yl)-1H-pyrazole is a pyrazolamine derivative that can be prepared by alkylation of nitropyrazole with alcohol and subsequent reduction.

Synthesis

1314987-79-5

1029413-51-1

The general procedure for the synthesis of tert-butyl 3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate from tert-butyl 3-(4-nitro-1H-pyrazol-1-yl)azetidine-1-carboxylate was carried out as follows: under an atmosphere of hydrogen gas (1 atmosphere), compound 54-b (1.33 g, 5 mmol) was dissolved in methanol (10 ml), 10% palladium carbon catalyst (0.1 g). The reaction mixture was stirred at 25 °C for 12 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the crude product compound 65-b (940 mg, 79% yield). The product could be used in subsequent reactions without further purification. Liquid chromatography-mass spectrometry (electrospray ionization) analysis showed: m/z = 261 [M + Na]+.

References

[1] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0406; 0407
[2] Tetrahedron Letters, 2008, vol. 49, # 18, p. 2996 - 2998
[3] Patent: EP2832734, 2015, A1. Location in patent: Paragraph 0521

tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate Suppliers

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View Lastest Price from tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate manufacturers

Career Henan Chemical Co

Product: tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate 1029413-51-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

1029413-51-1, tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylateRelated Search:

1-Boc-3-(4-amino-1-pyrazolyl)azetidine

tert-butyl3-(4-amino-1H-pyrazol-1-yl)azetidine-1-carboxylate

1-Azetidinecarboxylic acid, 3-(4-amino-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester

tert-butyl 3-(4-aminopyrazol-1-yl)azetidine-1-carboxylate

1029413-51-1