3'-Azido-3'-deoxy-3-deazauridine

Product Name: 3'-Azido-3'-deoxy-3-deazauridine
CAS No.: 2305416-04-8
Chemical Name: 3'-Azido-3'-deoxy-3-deazauridine
Synonyms: 3'-Azido-3'-deoxy-3-deazauridine;3’-Azido-3’-deoxy-3-deazauridine;3’-Azido-3’-deoxy-3-deazauridine, 4-Hydroxy-1-(3-azido-3-deoxy-beta-D-ribofuranosyl)-2(1H)-pyridinone
CBNumber: CB23035245
Molecular Formula: C10H12N4O5
Formula Weight: 268.23
MOL File: 2305416-04-8.mol

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3'-Azido-3'-deoxy-3-deazauridine Chemical Properties,Usage,Production

Uses

3’-Azido-3’-deoxy-3-deazauridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-3’-deoxy-3-deazauridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

3'-Azido-3'-deoxy-3-deazauridine Preparation Products And Raw materials

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2305416-04-8, 3'-Azido-3'-deoxy-3-deazauridineRelated Search:

3'-Azido-3'-deoxy-3-deazauridine

3’-Azido-3’-deoxy-3-deazauridine, 4-Hydroxy-1-(3-azido-3-deoxy-beta-D-ribofuranosyl)-2(1H)-pyridinone

3’-Azido-3’-deoxy-3-deazauridine

2305416-04-8