3'-Azido-3'-deoxy-3-deazauridine
- Product Name
- 3'-Azido-3'-deoxy-3-deazauridine
- CAS No.
- 2305416-04-8
- Chemical Name
- 3'-Azido-3'-deoxy-3-deazauridine
- Synonyms
- 3'-Azido-3'-deoxy-3-deazauridine;3’-Azido-3’-deoxy-3-deazauridine;3’-Azido-3’-deoxy-3-deazauridine, 4-Hydroxy-1-(3-azido-3-deoxy-beta-D-ribofuranosyl)-2(1H)-pyridinone
- CBNumber
- CB23035245
- Molecular Formula
- C10H12N4O5
- Formula Weight
- 268.23
- MOL File
- 2305416-04-8.mol
3'-Azido-3'-deoxy-3-deazauridine Chemical Properties,Usage,Production
Uses
3’-Azido-3’-deoxy-3-deazauridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-3’-deoxy-3-deazauridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
3'-Azido-3'-deoxy-3-deazauridine Preparation Products And Raw materials
Raw materials
Preparation Products
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