UAMC 00039 dihydrochloride
- Product Name
- UAMC 00039 dihydrochloride
- CAS No.
- 697797-51-6
- Chemical Name
- UAMC 00039 dihydrochloride
- Synonyms
- UAMC00039;UAMC00039 2HCl;UAMC 00039;UAMC-00039;UAMC 0039 (hydrochloride);UAMC 00039 dihydrochloride;UAMC00039dihydrochloride, >98%;UAMC00039 DIHYDROCHLORIDE, >98%;UAMC00039 dihydrochloride, 10 mM in DMSO;(S)-2-Amino-4-((4-chlorobenzyl)amino)-1-(piperidin-1-yl)butan-1-one dihydrochloride;(2S)-2-Amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone dihydrochloride
- CBNumber
- CB23037577
- Molecular Formula
- C16H25Cl2N3O
- Formula Weight
- 346.3
- MOL File
- 697797-51-6.mol
UAMC 00039 dihydrochloride Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMF: 2 mg/mL; DMSO: 14 mg/mL; Ethanol: 5 mg/mL; PBS (pH 7.2): 10 mg/mL
- form
- Powder
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 15340
- Product name
- UAMC 0039 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 15340
- Product name
- UAMC 0039 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 15340
- Product name
- UAMC 0039 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $266
- Updated
- 2024/03/01
- Product number
- 4954
- Product name
- UAMC00039dihydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $887
- Updated
- 2021/12/16
- Product number
- 4954
- Product name
- UAMC00039dihydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $244
- Updated
- 2021/12/16
UAMC 00039 dihydrochloride Chemical Properties,Usage,Production
Description
UAMC 0039 is a potent inhibitor of dipeptidyl peptidase 2 (DPP-2; IC50 = 0.48 nM). It also inhibits DPP-4 (IC50 = 165 μM). DPP-2 is thought to be involved in degradation of collagen, substance P, and some proline-containing neuropeptides.
Uses
UAMC 00039 Dihydrochloride is a highly potent and selective dipeptidase II inhibitor.
in vivo
A dose dependent inhibition of DPPII but not of DPPIV is observed in the peripheral organs of both the rats and the mice (after oral administration) and the rabbits (after IV administration). UAMC00039 tested orally at 2 mg/kg does not cause signs of acute toxicity and does not cause any significant changes in the following functions that are evaluated: general behaviour, body temperature, respiration, bleeding time, blood pressure, urine volume, liver function, fasting glucose and gastrointestinal parameters like acidity, motility and irritation[1].
References
[1] KRISTEL SENTEN. γ-Amino-Substituted Analogues of 1-[(S)-2,4-Diaminobutanoyl]piperidine as Highly Potent and Selective Dipeptidyl Peptidase II Inhibitors[J]. Journal of Medicinal Chemistry, 2004, 47 11: 2906-2916. DOI: 10.1021/jm031122f
[2] K J ANDERSEN J K M. Lysosomal heterogeneity of dipeptidyl peptidase II active on collagen-related peptides.[J]. Renal physiology and biochemistry, 1989, 12 1: 32-40. DOI: 10.1159/000173177
[3] ROLF MENTLEIN Gemot S. Purification of Two Dipeptidyl Aminopeptidases II from Rat Brain and Their Action on Proline-Containing Neuropeptides[J]. Journal of Neurochemistry, 1989, 52 4: 1284-1293. DOI: 10.1111/j.1471-4159.1989.tb01877.x
UAMC 00039 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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