Fruquintinib|HMPL-013

ChemicalBook > CAS DataBase List > Fruquintinib|HMPL-013

Product Name: Fruquintinib|HMPL-013
CAS No.: 1194506-26-7
Chemical Name: Fruquintinib|HMPL-013
Synonyms: CS-1643;HMPL-013;R-228060;EOS-61054;BMS-986472;Fruquintinib;Fruquintinib|HMPL-013;Fruquintinib|HMPL-013 USP/EP/BP;6-(6,7-dimethoxyquinazolin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide;6-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-3-benzofurancarboxamide
CBNumber: CB23037638
Molecular Formula: C21H19N3O5
Formula Weight: 393.39
MOL File: 1194506-26-7.mol

Less

Fruquintinib|HMPL-013 Property

Boiling point:: 600.5±55.0 °C(Predicted)
Density: 1.302±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 5 mg/ml).
pka: 14.35±0.46(Predicted)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 29425
Product name: Fruquintinib
Packaging: 10mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 29425
Product name: Fruquintinib
Packaging: 250mg
Price: $849
Updated: 2024/03/01

Cayman Chemical

Product number: 29425
Product name: Fruquintinib
Packaging: 50mg
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 29425
Product name: Fruquintinib
Packaging: 100mg
Price: $389
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0026222
Product name: FRUQUINTINIB
Purity: 95.00%
Packaging: 5MG
Price: $501.66
Updated: 2021/12/16

Less

Fruquintinib|HMPL-013 Chemical Properties,Usage,Production

Description

Fruquintinib is a VEGFR inhibitor (IC₅₀s = 33, 35, and 0.5 nM for VEGFR1, -2, and -3, respectively). It also inhibits RET, FGFR1, and c-Kit (IC₅₀s = 128, 181, and 458 nM, respectively) in a panel of 253 kinases. Fruquintinib inhibits VEGF-A-induced proliferation of human umbilical vein endothelial cells (HUVECs) and VEGF-C-induced proliferation of human lymphatic endothelial cells (HLECs; IC₅₀s = 1.7 and 4.2 nM, respectively). It decreases tube formation by HUVECs by 74 and 94% when used at concentrations of 30 and 300 nM, respectively. Fruquintinib (0.5-20 mg/kg per day for 21 days) reduces tumor growth in BGC-823, HT-29, Caki-1, and NCI H460 mouse xenograft models.

Uses

Fruquintinib is a multi-targeted tyrosine kinase inhibitor, a third-line regimen involved in the treatment of advanced non-small cell lung cancer in humans. Fruquintinib is a potent, highly selective and orally active inhibitor of VEGFR1, 2, 3 tyrosine kinases.

in vitro

fruquintinib was found to inhibit vegfr2 with an ic50 of 25 nmol/l. the kinase selectivity of fruquintinib was evaluated against a panel of 253 kinases. the results showed that fruquintinib inhibited vegfr family members with weak inhibition of ret, fgfr-1 and c-kit kinases [1].

in vivo

anti-tumor activity of fruquintinib was evaluated in a variety of tumor xenografts. the results from gastric cancer bgc-823 model seemed to indicate that the drug concentration needs to be at least maintained above ec85 for around 8 hours in order to achieve >80% tumor growth inhibition. bgc-823 was found to be most sensitive to fruquintinib [1].

IC 50

33 nmol/l, 35 nmol/l and 0.5 nmol/l for vegfr1, 2, 3

References

1) Sun?et al.?(2014)?Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1,2,3 tyrosine kinases for cancer therapy; Cancer Biol. Ther.?15?1635 2) Li?et al.?(2018)?Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer: The FRESCO Randomized Clinical Trial; JAMA?319?2486 3) Lu?et al.?(2018)?Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase II Study of Fruquintinib After Two Prior Chemotherapy Regimens in Chinese Patients With Advanced Nonsquamous Non-Small-cell Lung Cancer; J. Clin. Oncol.?36?1207

Fruquintinib|HMPL-013 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Fruquintinib|HMPL-013 Suppliers

Canada 1 China 132 India 2 United Kingdom 1 United States 13 Global 149

Wuhan Jingkangen Biomedical Technology Co., Ltd

Tel: 13720134139 13720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 4955
Advantage: 58

Jinan Cen Ben Medical Technology Co., Ltd

Tel: 0531-0531-69959492 14793566
Email: info@cenpharm.com
Country: China
ProdList: 701
Advantage: 58

Shandong utilizing biological technology co., LTD

Tel: 15966937598
Fax: 3407640895 3071519937
Email: 3407650895@qq.com
Country: China
ProdList: 1002
Advantage: 58

Mancinor Technology Co., Ltd.

Tel: 19719236623
Email: 2885515945@qq.com
Country: China
ProdList: 1793
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15342225168
Email: yutianchun2007@126.com
Country: China
ProdList: 9964
Advantage: 58

Jinan Demai Medical Technology Co., LTD

Tel: 18669728830
Email: 865681093@qq.com
Country: China
ProdList: 430
Advantage: 58

Shaanxi Istare Biotechnology Co., Ltd.

Tel: 029-81530825 18682931470
Email: 2142355700@qq.com
Country: China
ProdList: 1418
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-020-82000279 18988968278
Fax: QQ：3283937693
Email: sales@ubiochem.com
Country: China
ProdList: 2357
Advantage: 58

Nanjing Pope Bio-tech R&D Co., Ltd

Tel: 025-87138562 18951783565
Email: sales@popebiotech.com
Country: China
ProdList: 1016
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

BeiJing Hwrk Chemicals Limted

Tel: 0757-86329057 18501085097
Fax: 010-89508210
Email: sales3.gd@hwrkchemical.com
Country: China
ProdList: 7583
Advantage: 55

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

Aloespharm Co., Ltd.

Tel: 021-20960837
Fax: 021-20960837
Email: market@aloespharm.com
Country: China
ProdList: 1303
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3421
Advantage: 58

Suzhou Sino Rare Chemical Co., Ltd.

Tel: 0512-62857507
Fax: +86-512-62857507
Email: sales@sinorarechem.com
Country: China
ProdList: 981
Advantage: 58

Shanghai Taibao Pharmaceutical Technology Co., Ltd.

Tel: 13816752554
Email: 1745533547@qq.com
Country: China
ProdList: 128
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17982
Advantage: 56

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15878
Advantage: 55

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4121
Advantage: 55

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

Shanghai Biolang biotechnology Co.,Ltd

Tel: 17764003753
Fax: 13669031409
Email: 2326587775@qq.com
Country: China
ProdList: 188
Advantage: 55

Shanghai Biolang biotechnology Co.,Ltd

Tel: 17764003753
Fax: 13669031409
Email: 2326587775@qq.com
Country: China
ProdList: 188
Advantage: 55

Shanghai Synchem Pharma Co., ltd

Tel: 021-61984905-1 18016477331
Email: synchempharma@aliyun.com
Country: China
ProdList: 6454
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 316
Advantage: 55

skychemical Co.Ltd

Tel: 021-20960837,QQ1332204249
Fax: 021-20960837
Email: sales@skychemical.com
Country: China
ProdList: 3317
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Chengdu HuaNa Chemicals Co., Ltd.

Tel: 028-86612776; 13699069380
Fax: -
Email: 515238037@qq.com
Country: China
ProdList: 963
Advantage: 55

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2982
Advantage: 58

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 5426
Advantage: 58

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6357
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 9859
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29797
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Shanghai Resuperpharmtech Co., Ltd.

Tel: 17321237488
Email: kevin@resuperpharmtech.com
Country: China
ProdList: 370
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1832
Advantage: 55

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Kaixin Chemical (Hong Kong) Limited

Tel: 010-88886666-01 13112345678
Fax: CDXH21@126.com
Email: loyson@tcypharm.com
Country: China
ProdList: 595
Advantage: 55

Dezhou LonWel Pharmaceutical Technology Co., Ltd.

Tel: 13761310616
Fax: QQ: 39324283
Email: 39324283@qq.com
Country: China
ProdList: 1946
Advantage: 58

Heze Development Zone chuangli Chemical Co., Ltd.

Tel: +86-530-529 6766，+86-15666160102 15666160102
Fax: 0530-529 6766
Email: info@chuangli-chem.com
Country: China
ProdList: 877
Advantage: 55

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83778895 18602735115
Fax: 027-51119224
Email: 18602735115@163.com
Country: China
ProdList: 1994
Advantage: 64

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Country: China
ProdList: 1988
Advantage: 58

Less

View Lastest Price from Fruquintinib|HMPL-013 manufacturers

Hebei Duling International Trade Co. LTD

Product: Fruquintinib|HMPL-013 1194506-26-7
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2022-09-30

Zhengzhou Anbu Chem Co.,Ltd

Product: Fruquintinib|HMPL-013 1194506-26-7
Price: US $0.00/KG
Min. Order: 0.1KG
Purity: 98%
Supply Ability: 1000KGS
Release date: 2023-07-14

Dideu Industries Group Limited

Product: Fruquintinib|HMPL-013 1194506-26-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-06

1194506-26-7, Fruquintinib|HMPL-013Related Search:

Everolimus Imatinib HACHIMYCIN CINITAPRIDE HYDROGEN TARTRATE Panitumumab Capecitabine Sorafenib 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Afatinib (BIBW 2992) Gefitinib Lapatinib 17-AAG Erlotinib hydrochloride Dasatinib Imatinib mesylate Bevacizumab Icotinib (Hydrochloride) Icotinib

CS-1643

Fruquintinib|HMPL-013

Fruquintinib

6-(6,7-dimethoxyquinazolin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide

HMPL-013

3-Benzofurancarboxamide, 6-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-

6-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-3-benzofurancarboxamide

R-228060

6-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-1-benzofuran-3-carboxamide

EOS-61054

Fruquintinib|HMPL-013 USP/EP/BP

BMS-986472

1194506-26-7

Inhibitors