ravidasvir hydrochloride

Product Name: ravidasvir hydrochloride
CAS No.: 1303533-81-4
Chemical Name: ravidasvir hydrochloride
Synonyms: Ravidasvir HCl;ravidasvir hydrochloride;Ravidasvir dihydrochloride;PPI-668; BI 238630;PPI 668;PPI668;Ravidasvir hydrochloride (PPI-668);Methyl N-[(1S)-1-[[(2S)-2-[5-[6-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-benzimidazol-6-yl]-2-naphthalenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamate dihydrochloride
CBNumber: CB23038529
Molecular Formula: C42H52Cl2N8O6
Formula Weight: 835.81828
MOL File: 1303533-81-4.mol

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ravidasvir hydrochloride Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMF: 5 mg/ml
DMSO: 5 mg/ml
Ethanol: 1 mg/ml
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS145614
Product name: RavidasvirHCl
Purity: 95%
Packaging: 250mg
Price: $409
Updated: 2021/12/16

Ambeed

Product number: A1211703
Product name: MethylN-[(1S)-1-[[(2S)-2-[5-[6-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-benzimidazol-6-yl]-2-naphthalenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamatedihydrochloride
Purity: 95%
Packaging: 100mg
Price: $120
Updated: 2021/12/16

Ambeed

Product number: A1211703
Product name: MethylN-[(1S)-1-[[(2S)-2-[5-[6-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-benzimidazol-6-yl]-2-naphthalenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamatedihydrochloride
Purity: 95%
Packaging: 250mg
Price: $206
Updated: 2021/12/16

DC Chemicals

Product number: DC8190
Product name: Ravidasvirhydrochloride(PPI-668)
Purity: >98%
Packaging: 100mg
Price: $450
Updated: 2021/12/16

Ambeed

Product number: A1211703
Product name: MethylN-[(1S)-1-[[(2S)-2-[5-[6-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-benzimidazol-6-yl]-2-naphthalenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamatedihydrochloride
Purity: 95%
Packaging: 1g
Price: $511
Updated: 2021/12/16

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ravidasvir hydrochloride Chemical Properties,Usage,Production

Uses

Ravidasvir hydrochloride (PPI-668 hydrochloride) is a pan-genotypic inhibitor for hepatitis C virus (HCV) NS5A protein. Ravidasvir hydrochloride inhibits the replication of HCV, with EC50 of 0.12, 0.01 and 1.14 nM, for HCV gt-1a, gt-1b, and gt-3a replicons, respectively. Ravidasvir hydrochloride exhibits good pharmacokinetic characters in rats[1].

Mechanism of action

Ravidasvir hydrochloride is an oral HCV NS5A inhibitor that blocks viral replication by inhibiting the NS5A protein.

Synthesis

Starting material: 2-bromonaphthalene; the core of the naphthalene-imidazole moiety was assembled from 2-bromonaphthalene in three steps: Friedel-Crafts acylation using chloroacetyl chloride and aluminum chloride afforded the α-chloroketone. Alkylation of the α-chloroketone with N-Boc-L-proline (41) afforded the diketone intermediate. Cyclization of the diketone intermediate to form imidazole 42 was performed by heating in the presence of ammonium acetate. Miyaura borylation of imidazole 42 afforded the corresponding boronic ester. The resulting boronic ester was coupled with benzimidazole 43 under Suzuki conditions to convergently assemble the benzimidazole-naphthalene-imidazole core 44. Removal of the Boc protecting group under acidic conditions followed by double acylation using N-Moc-L-valine (45) and EDCI afforded the ravidasvir free base. Treatment of the ravidasvir free base with hydrochloric acid followed by crystallization from ethanol and n-butyl acetate afforded ravidasvir hydrochloride (VI).

References

[1] Zhong M, et al., Discovery of ravidasvir (PPI-668) as a potent pan-genotypic HCV NS5A inhibitor. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4508-4512. DOI:10.1016/j.bmcl.2016.07.066

ravidasvir hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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ravidasvir hydrochloride Suppliers

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1303533-81-4, ravidasvir hydrochlorideRelated Search:

ravidasvir hydrochloride

Ravidasvir dihydrochloride

PPI-668; BI 238630;PPI 668;PPI668

Ravidasvir HCl

Ravidasvir hydrochloride (PPI-668)

Methyl N-[(1S)-1-[[(2S)-2-[5-[6-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-benzimidazol-6-yl]-2-naphthalenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamate dihydrochloride

1303533-81-4

C42H50N8O62HCl