methyl 2-cyclohexyl-2-oxoacetate
- Product Name
- methyl 2-cyclohexyl-2-oxoacetate
- CAS No.
- 62783-63-5
- Chemical Name
- methyl 2-cyclohexyl-2-oxoacetate
- Synonyms
- methyl 2-cyclohexyl-2-oxoacetate;Cyclohexaneacetic acid, α-oxo-, methyl ester;Cyclohexaneacetic acid, a-oxo-, methyl ester
- CBNumber
- CB23040874
- Molecular Formula
- C9H14O3
- Formula Weight
- 170.21
- MOL File
- 62783-63-5.mol
methyl 2-cyclohexyl-2-oxoacetate Property
- Boiling point:
- 50-52 °C(Press: 0.3 Torr)
- Density
- 1.079±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- AK155938
- Product name
- Methyl2-cyclohexyl-2-oxoacetate
- Purity
- 97%
- Packaging
- 5g
- Price
- $848
- Updated
- 2021/12/16
- Product number
- A175461
- Product name
- Methyl2-cyclohexyl-2-oxoacetate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- A175461
- Product name
- Methyl2-cyclohexyl-2-oxoacetate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- CM200891
- Product name
- methyl2-cyclohexyl-2-oxoacetate
- Purity
- 97%
- Packaging
- 1g
- Price
- $163
- Updated
- 2021/12/16
- Product number
- A175461
- Product name
- Methyl2-cyclohexyl-2-oxoacetate
- Purity
- 97%
- Packaging
- 1g
- Price
- $232
- Updated
- 2021/12/16
methyl 2-cyclohexyl-2-oxoacetate Chemical Properties,Usage,Production
Synthesis Reference(s)
Tetrahedron Letters, 18, p. 2825, 1977 DOI: 10.1016/S0040-4039(01)83085-9
Synthesis
67-56-1
50284-86-1
62783-63-5
To a methanol (5 mL) solution of 1-chloro-2-cyclohexylethane (0.50 mmol, purchased from ChemSampCo, Inc.) was added a water (5 mL) solution of sodium bicarbonate (23 mg, 0.28 mmol) and magnesium sulfate (135 mg, 1.10 mmol). The reaction mixture was stirred vigorously at 0°C for 10 min, followed by the addition of potassium permanganate (260 mg, 1.70 mmol). The mixture was warmed to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the solid residue was removed by filtration through a diatomaceous earth pad and the filter cake was washed with ethyl acetate. The organic phase was separated and the aqueous phase was extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, washed with brine (30 mL) and dried with magnesium sulfate. The organic phases were concentrated and purified by fast column chromatography (eluent: hexane/ethyl acetate, 5:1) to afford the target product methyl 2-cyclohexyl-2-oxoacetate (78 mg, 90% yield). Thin Layer Chromatography (TLC, Expanding Agent: Hexane/Ethyl Acetate, 5:1): Rf = 0.40. Mass Spectrometry (ESI) m/z: 171.49 [M + H]+ (Calculated value: 171.16 [M + H]+).
References
[1] Patent: WO2013/91900, 2013, A1. Location in patent: Page/Page column 36
methyl 2-cyclohexyl-2-oxoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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