CNV1014802 (hydrochloride)

Product Name: CNV1014802 (hydrochloride)
CAS No.: 934240-31-0
Chemical Name: CNV1014802 (hydrochloride)
Synonyms: GSK1014802A;CNV1014802 HCl;Raxatrigine HCl;GSK-1014802 HCl;GSK-1014802 hydrochloride;Raxatrigine hydrochloride;CNV1014802 (hydrochloride);CNV1014802(Raxatrigine) hydrochloride;Raxatrigine hydrochloride(GSK1014802);Raxatrigine HCl (GSK1014802, CNV1014802)
CBNumber: CB23041396
Molecular Formula: C18H20ClFN2O2
Formula Weight: 350.8150032
MOL File: 934240-31-0.mol

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CNV1014802 (hydrochloride) Property

Melting point:: >206°C (dec.)
storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: Solid
color: White to Off-White
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23490
Product name: Raxatrigine (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 23490
Product name: Raxatrigine (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 23490
Product name: Raxatrigine (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 23490
Product name: Raxatrigine (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $573
Updated: 2024/03/01

TRC

Product number: R128055
Product name: RaxatrigineHydrochloride
Packaging: 100mg
Price: $1280
Updated: 2021/12/16

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CNV1014802 (hydrochloride) Chemical Properties,Usage,Production

Uses

Raxatrigine Hydrochloride is used as co-therapy for the treatment of epilepsy and related disorders.

Synthesis

934240-30-9

934240-31-0

(2S,5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide (5.46 g, 17.37 mmol) was used as a raw material, which was dissolved in ethyl acetate (140 mL), stirred for 30 min and filtered. To the filtrate was added a dioxane solution (6.51 mL, 26.05 mmol) in 4 M HCl and the reaction was stirred at room temperature for 20 minutes, followed by cooling in an ice bath for 15 minutes. The resulting solid was collected by filtration, washed with cold ethyl acetate (2 x 20 mL) and dried under vacuum first at 35 °C overnight and then at 50 °C for 2 h to give an off-white solid product (E1, 5.87 g, 96% yield).LC-MS showed MH+ = 315 (corresponding to molecular formula C18H19FN2O2).1H NMR (d6-DMSO) data were as follows: δ 1.95-2.20 (2H, m), 2.30 (2H, m), 3.35 (1H, s), 4.30 (1H, m), 4.61 (1H, m), 5.18 (2H, s), 7.10 (2H, d, J = 9 Hz), 7.18-7.30 (2H, m), 7.40 (1H, m), 7.47 (2H, d, J = 9 Hz), 7.56 (1H, s), 7.72 (1H, s), 8.07 (1H, s), 10.60 (1H, br s).

IC 50

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References

[1] Patent: WO2016/102967, 2016, A1. Location in patent: Page/Page column 43
[2] Patent: WO2011/29762, 2011, A1. Location in patent: Page/Page column 23-24
[3] Patent: WO2007/42239, 2007, A1. Location in patent: Page/Page column 45
[4] Patent: WO2007/42239, 2007, A1. Location in patent: Page/Page column 45-46
[5] Patent: WO2007/42239, 2007, A1. Location in patent: Page/Page column 46

CNV1014802 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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CNV1014802 (hydrochloride) Suppliers

China 54 India 2 United States 6 Global 62

Chembest Research Laboratories Limited

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934240-31-0