ChemicalBook > CAS DataBase List > E6446

E6446

Product Name
E6446
CAS No.
1219925-73-1
Chemical Name
E6446
Synonyms
E6446;E6446 ，S0716;E 6446 (E6446);E6446(free base);Benzoxazole, 6-[3-(1-pyrrolidinyl)propoxy]-2-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-;6-(3-Pyrrolidin-1-yl-propoxy)-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-benzooxazole;6-(3-(Pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole
CBNumber
CB23041402
Molecular Formula
C27H35N3O3
Formula Weight
449.59
MOL File
1219925-73-1.mol
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E6446 Property

Boiling point:
587.7±50.0 °C(Predicted)
Density 
1.151±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Ethanol:90.0(Max Conc. mg/mL);200.18(Max Conc. mM)
form 
Solid
pka
10.16±0.20(Predicted)
color 
Off-white to pink
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Crysdot
Product number
CD31004235
Product name
E6446
Purity
98+%
Packaging
5mg
Price
$243
Updated
2021/12/16
Crysdot
Product number
CD31004235
Product name
E6446
Purity
98+%
Packaging
10mg
Price
$451
Updated
2021/12/16
DC Chemicals
Product number
DC20986
Product name
E6446
Purity
>98%
Packaging
100mg
Price
$700
Updated
2021/12/16
Crysdot
Product number
CD31004235
Product name
E6446
Purity
98+%
Packaging
50mg
Price
$1389
Updated
2021/12/16
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E6446 Chemical Properties,Usage,Production

Uses

E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD)[1][2][3].

in vivo

E6446 (20 mg/kg, p.o.) almost cmlpletely inhibits CpG1668-induced IL-6 production, and dose-dependently suppresses the development of ANA (anti-nuclear antibodies) in mice at 20 and 60 mg/kg[1]. E6446 (20, 60 mg/kg, p.o.) dose-dependently inhibits TLR9 signaling in mice. E6446 (60, 120 mg/kg, p.o.) prevents hyperresponsiveness of TLRs and LPS-induced septic shock in rodent malaria, diminishes TLR responsiveness during acute malaria, suppresses activation of both TLR7 and TLR9[2].

IC 50

TLR7; TLR9

References

[1] Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. DOI:10.1124/mol.113.089821
[2] Franklin BS, et al. Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94. DOI:10.1073/pnas.1015406108
[3] Wang W, et al. Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease: critical role of liver-adipose axis. Cell Commun Signal. 2023 Sep 30;21(1):268. DOI:10.1186/s12964-023-01297-9

E6446 Preparation Products And Raw materials

Raw materials

Preparation Products

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E6446 Suppliers

China 44 United States 5 Global 49
Shanghai Topbiochem Technology Co., Ltd
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021-58170097
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info@topbiochem.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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China
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71826
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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Angel Pharmatech, Ltd.
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China
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58
Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
Email
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China
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9729
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022-23989838 13810451150
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career henan chemical co
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Beijing Haite lesk Technology Co., Ltd
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Absin Bioscience Inc.
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Advanced chemblocks inc
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InvivoChem
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Nanjing Shizhou Biology Technology Co.,Ltd
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Hubei wei shi reagent group ltd., company
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HANGZHOU LEAP CHEM CO., LTD.
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Biorbyt Ltd.
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Absin Bioscience Inc.
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Proteintech China
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View Lastest Price from E6446 manufacturers

Career Henan Chemical Co
Product
E6446 1219925-73-1
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-24

1219925-73-1, E6446Related Search:


  • E6446
  • E6446(free base)
  • E 6446 (E6446)
  • Benzoxazole, 6-[3-(1-pyrrolidinyl)propoxy]-2-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-
  • 6-(3-(Pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole
  • 6-(3-Pyrrolidin-1-yl-propoxy)-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-benzooxazole
  • E6446 ，S0716
  • 1219925-73-1