ChemicalBook > CAS DataBase List > p38 MAPK-IN-1

p38 MAPK-IN-1

Product Name
p38 MAPK-IN-1
CAS No.
1006378-90-0
Chemical Name
p38 MAPK-IN-1
Synonyms
CS-2117;p38 MAPK-IN-4;p38 MAPK-IN-1;p-38 MAPK-IN-1,p38 MAPKIN1,p38 MAPK IN 1;1,7-Naphthyridine, 4-(2,4-difluorophenyl)-8-(2-methylphenyl)-, 7-oxide
CBNumber
CB23041442
Molecular Formula
C21H14F2N2O
Formula Weight
348.35
MOL File
1006378-90-0.mol
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p38 MAPK-IN-1 Property

Boiling point:
527.0±50.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 8.33 mg/mL (23.84 mM)
form 
Solid
pka
0.26±0.40(Predicted)
color 
Off-white to yellow
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-4225
Product name
p38MAPK-IN-1
Purity
98.91%
Packaging
5mg
Price
$420
Updated
2021/12/16
Apolloscientific
Product number
BISN0235
Product name
P38 mapk-in-1
Packaging
5mg
Price
$473
Updated
2021/12/16
ChemScene
Product number
CS-4225
Product name
p38MAPK-IN-1
Purity
98.91%
Packaging
10mg
Price
$600
Updated
2021/12/16
Apolloscientific
Product number
BISN0235
Product name
P38 mapk-in-1
Packaging
10mg
Price
$675
Updated
2021/12/16
Apolloscientific
Product number
BISN0235
Product name
P38 mapk-in-1
Packaging
1mg
Price
$203
Updated
2021/12/16
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p38 MAPK-IN-1 Chemical Properties,Usage,Production

Uses

p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability.

in vivo

p38 MAPK-IN-1 (Compound 4; 1 mg/kg for iv and 10 mg/kg for po) has a t1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a Cmax of 5.3 μM for po in male wistar rats[1].
p38 MAPK-IN-1 dose-dependently inhibits TNFα production with an ED50 of 0.5 mg/kg[1].

Animal Model:Male wistar rats[1]
Dosage:10 mg/kg for po and 1 mg/kg for iv (Pharmacokinetic Analysis)
Administration:Po and iv
Result:Had a t1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a Cmax of 5.3 μM for po.

IC 50

p38 MAPK: 68 nM (IC50)

References

[1] Lumeras W, et al. 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem. 2011 Nov 24;54(22):7899-910. DOI:10.1021/jm200975u

p38 MAPK-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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p38 MAPK-IN-1 Suppliers

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1006378-90-0, p38 MAPK-IN-1Related Search:


  • p38 MAPK-IN-1
  • CS-2117
  • p38 MAPK-IN-4
  • 1,7-Naphthyridine, 4-(2,4-difluorophenyl)-8-(2-methylphenyl)-, 7-oxide
  • p-38 MAPK-IN-1,p38 MAPKIN1,p38 MAPK IN 1
  • 1006378-90-0