2-hydroxy-5-(methylthio)benzaldehyde
- Product Name
- 2-hydroxy-5-(methylthio)benzaldehyde
- CAS No.
- 67868-84-2
- Chemical Name
- 2-hydroxy-5-(methylthio)benzaldehyde
- Synonyms
- 2-hydroxy-5-(methylthio)benzaldehyde;Benzaldehyde, 2-hydroxy-5-(methylthio)-;2-HYDROXY-5-(METHYLSULFANYL)BENZALDEHYDE
- CBNumber
- CB23041730
- Molecular Formula
- C8H8O2S
- Formula Weight
- 168.21
- MOL File
- 67868-84-2.mol
2-hydroxy-5-(methylthio)benzaldehyde Property
- Boiling point:
- 114-118 °C(Press: 4 Torr)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.00±0.18(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 7039CT
- Product name
- 2-Hydroxy-5-(methylthio)benzaldehyde
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 7039CT
- Product name
- 2-Hydroxy-5-(methylthio)benzaldehyde
- Packaging
- 1g
- Price
- $219
- Updated
- 2021/12/16
- Product number
- 181646
- Product name
- 2-Hydroxy-5-methylsulfanylbenzaldehyde
- Purity
- 95%
- Packaging
- 5g
- Price
- $1568
- Updated
- 2021/12/16
- Product number
- A141055
- Product name
- 2-Hydroxy-5-(methylthio)benzaldehyde
- Purity
- 97%
- Packaging
- 100mg
- Price
- $18
- Updated
- 2021/12/16
- Product number
- A141055
- Product name
- 2-Hydroxy-5-(methylthio)benzaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $38
- Updated
- 2021/12/16
2-hydroxy-5-(methylthio)benzaldehyde Chemical Properties,Usage,Production
Synthesis
50-00-0
1073-72-9
67868-84-2
To a suspension of 4-(methylthio)phenol (50 g, 357 mmol), paraformaldehyde (72.3 g, 2407 mmol) and anhydrous magnesium chloride (50.9 g, 535 mmol) in acetonitrile (500 mL) was added triethylamine (186 mL, 1337 mmol). The reaction mixture was stirred at room temperature and then warmed to 60 °C and stirred continuously for 5 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and 1N hydrochloric acid was slowly added until the two phases separated (~1.5 L). Methyl tert-butyl ether (MTBE, 700 mL) was then added and the organic layer was separated. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography on silica gel with the eluent being a 1:1 hexane/dichloromethane solvent mixture to afford 2-hydroxy-5-(methylthio)benzaldehyde (50.5 g, 300 mmol, 84% yield) as a semi-solid.
References
[1] Patent: WO2015/35223, 2015, A1. Location in patent: Paragraph 0821
[2] Patent: WO2016/57242, 2016, A1. Location in patent: Paragraph 0197
[3] Journal of the American Chemical Society, 2009, vol. 131, # 40, p. 14190 - 14191
[4] Angewandte Chemie - International Edition, 2011, vol. 50, # 21, p. 4983 - 4987
[5] European Journal of Organic Chemistry, 2014, vol. 2014, # 27, p. 6077 - 6083
2-hydroxy-5-(methylthio)benzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-hydroxy-5-(methylthio)benzaldehyde manufacturers
- Product
- 2-hydroxy-5-methylsulfanylbenzaldehyde 67868-84-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.3%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14