ChemicalBook > CAS DataBase List > 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one

2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one

Product Name
2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
CAS No.
635324-72-0
Chemical Name
2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
Synonyms
MDK24720;CTLA-4 - INHIBITO;CTLA-4 - INHIBITOR;CTLA-4 inhibitor 1;MDK 24720 (CTLA-4 inhibitor);B7/CD28 interaction inhibitor 1;2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b;2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one;2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one;2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one
CBNumber
CB23048865
Molecular Formula
C21H13F4N5O
Formula Weight
427.35
MOL File
635324-72-0.mol
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2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one Property

Boiling point:
599.5±60.0 °C(Predicted)
Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
5.76±0.20(Predicted)
form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Crysdot
Product number
CD11082858
Product name
2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
Purity
97%
Packaging
100mg
Price
$269
Updated
2021/12/16
Ambeed
Product number
A338124
Product name
2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
Purity
97%
Packaging
100mg
Price
$302
Updated
2021/12/16
DC Chemicals
Product number
DC8784
Product name
CTLA-4inhibitor
Purity
>98%
Packaging
10mg
Price
$350
Updated
2021/12/16
Alichem
Product number
635324720
Product name
2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
Packaging
50mg
Price
$352.8
Updated
2021/12/16
Alichem
Product number
635324720
Product name
2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
Packaging
100mg
Price
$539
Updated
2021/12/16
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2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one Chemical Properties,Usage,Production

Biological Activity

MDK 24720 (CTLA-4 inhibitor, copmound 6b) is a Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4, CD152) inhibitor with IC50 of 50 nM for B7.1–CD28 inhibition.

in vitro

Bivalent CTLA4 homodimers bridge bivalent B7.1 homodimers to form an unusually stable signaling complex. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory antigen molecules on T cells with B7 molecules on presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases.

target

TargetValue
CD152
()
B7.1–CD28
(Cell-free assay)		 50 nM

2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one Suppliers

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635324-72-0, 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-oneRelated Search:


  • CTLA-4 - INHIBITOR
  • 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
  • CTLA-4 - INHIBITO
  • MDK24720
  • B7/CD28 interaction inhibitor 1
  • Dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one, 2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]-
  • 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b
  • CTLA-4 inhibitor 1
  • B7/CD28 interaction inhibitor 1,antibodies,T-cell,Inhibitor,inhibit,CTLA-4,responses,immunosuppression,B7.1,B-7/CD28 interaction inhibitor 1,CD28
  • MDK 24720 (CTLA-4 inhibitor)
  • 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
  • 2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one
  • 635324-72-0
  • C21H13F4N5O