7-chloro-3,4-dihydroisoquinoline
- Product Name
- 7-chloro-3,4-dihydroisoquinoline
- CAS No.
- 60518-41-4
- Chemical Name
- 7-chloro-3,4-dihydroisoquinoline
- Synonyms
- 7-chloro-3,4-dihydroisoquinoline;Isoquinoline, 7-chloro-3,4-dihydro-
- CBNumber
- CB23049105
- Molecular Formula
- C9H8ClN
- Formula Weight
- 165.62
- MOL File
- 60518-41-4.mol
7-chloro-3,4-dihydroisoquinoline Property
- Boiling point:
- 277.0±40.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.54±0.20(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A162087
- Product name
- 7-Chloro-3,4-dihydroisoquinoline
- Purity
- 95%
- Packaging
- 100mg
- Price
- $6
- Updated
- 2021/12/16
- Product number
- A162087
- Product name
- 7-Chloro-3,4-dihydroisoquinoline
- Purity
- 95%
- Packaging
- 250mg
- Price
- $9
- Updated
- 2021/12/16
- Product number
- A162087
- Product name
- 7-Chloro-3,4-dihydroisoquinoline
- Purity
- 95%
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- A162087
- Product name
- 7-Chloro-3,4-dihydroisoquinoline
- Purity
- 95%
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CM223627
- Product name
- 7-Chloro-3,4-dihydroisoquinoline
- Purity
- 95%
- Packaging
- 1g
- Price
- $153
- Updated
- 2021/12/16
7-chloro-3,4-dihydroisoquinoline Chemical Properties,Usage,Production
Synthesis
82771-60-6
60518-41-4
Example 32: Synthesis of 7-chloro-3,4-dihydroisoquinoline (Int-50) To a solution of 7-chloro-1,2,3,4-tetrahydroisoquinoline (1.15 g, 6.86 mmol) in dichloromethane (DCM, 70.0 mL) was added manganese dioxide (MnO2, 5.96 g, 68.6 mmol) at room temperature. The reaction mixture was stirred for 16 hours. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the residual solids were washed several times with dichloromethane (DCM). The filtrates were combined and concentrated under reduced pressure to give the crude product. The crude product was purified by ISCO silica gel column chromatography (40 g silica gel, eluent 50% ethyl acetate (EtOAc) in dichloromethane (DCM) solution at a flow rate of 50 mL/min) to give 915 mg of the title compound 7-chloro-3,4-dihydroisoquinoline as a colorless solid. NMR hydrogen spectrum (400 MHz, DMSO-d6) δ 8.35 (t, J = 2.1 Hz, 1H), 7.52 (d, J = 2.2 Hz, 1H), 7.46 (dd, J = 8.0, 2.3 Hz, 1H), 7.28 (d, J = 8.0 Hz, 1H), 3.70-3.63 (m, 2H), 2.71-2.65 ( m, 2H).
References
[1] Patent: WO2016/4136, 2016, A1. Location in patent: Paragraph 00379
7-chloro-3,4-dihydroisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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