1,4-bis(trifluoromethyl)-2,5-dibromobenzene

Product Name: 1,4-bis(trifluoromethyl)-2,5-dibromobenzene
CAS No.: 2375-96-4
Chemical Name: 1,4-bis(trifluoromethyl)-2,5-dibromobenzene
Synonyms: 1,4-dibromo-2,5-bis(trifluoromethyl)benzene;1,4-bis(trifluoromethyl)-2,5-dibromobenzene;2,5-Bis(trifluoromethyl)-1,4-dibromobenzene;Benzene, 1,4-dibromo-2,5-bis(trifluoromethyl)-;1,4-Bis(trifluoromethyl)-2,5-dibromobenzene - [B94512]
CBNumber: CB23050796
Molecular Formula: C8H2Br2F6
Formula Weight: 371.9
MOL File: 2375-96-4.mol

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1,4-bis(trifluoromethyl)-2,5-dibromobenzene Property

Melting point:: 72.0-72.5 °C
Boiling point:: 112.0 °C(Press: 40 Torr)
Density: 1.969±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: solid
color: Faint yellow
InChI: InChI=1S/C8H2Br2F6/c9-5-1-3(7(11,12)13)6(10)2-4(5)8(14,15)16/h1-2H
InChIKey: ZEVVDSRCWJRHSX-UHFFFAOYSA-N
SMILES: C1(Br)=CC(C(F)(F)F)=C(Br)C=C1C(F)(F)F

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Safety

HS Code: 2903998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SIK2106-11
Product name: 1,4-Dibromo-2,5-bis(trifluoromethyl)benzene
Purity: ≥97%
Packaging: 250MG
Price: $158
Updated: 2025/07/31

Sigma-Aldrich

Product number: SIK2106-11
Product name: 1,4-Dibromo-2,5-bis(trifluoromethyl)benzene
Purity: ≥97%
Packaging: 1G
Price: $451
Updated: 2025/07/31

Oakwood

Product number: 099968
Product name: 1,4-Dibromo-2,5-bis(trifluoromethyl)benzene
Purity: 98%
Packaging: 25g
Price: $3450
Updated: 2021/12/16

Crysdot

Product number: CD12093053
Product name: 1,4-Bis(trifluoromethyl)-2,5-dibromobenzene
Purity: 95+%
Packaging: 1g
Price: $236
Updated: 2021/12/16

Crysdot

Product number: CD12093053
Product name: 1,4-Bis(trifluoromethyl)-2,5-dibromobenzene
Purity: 95+%
Packaging: 5g
Price: $471
Updated: 2021/12/16

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1,4-bis(trifluoromethyl)-2,5-dibromobenzene Chemical Properties,Usage,Production

Synthesis

433-19-2

2375-96-4

General procedure for the synthesis of 1,4-dibromo-2,5-bis(trifluoromethyl)benzene from 2,3-difluorotoluene: 1. 1,4-bis(trifluoromethyl)benzene (19 g, 88.7 mmol, ABCR), trifluoroacetic acid (250 ml, SDS), and 99% sulfuric acid (60 ml, Acros) were sequentially added to a 1-liter round-bottomed flask fitted with a condenser and magnetic stirrer. 2. The reaction mixture was heated to 60 °C at which temperature N-bromosuccinimide (47.4 g, 267 mmol, Aldrich) was added in batches and the dosing process lasted for 5 hours. 3. After completion of the addition, the reaction was kept at 60 °C with continued stirring for 48 hours. 4. The reaction mixture was poured into ice (500 ml) and precipitate was precipitated and collected by filtration. 5. The precipitate was dried under vacuum (1 mmHg) for 24 hours. 6. The dried product was purified by sublimation to give 30 g (91% yield) of white solid product 2,5-dibromo-1,4-bis(trifluoromethyl)benzene. Product characterization: - Melting point: 65±0.2°C; - 1H NMR (200MHz, CDCl3): δ 8.01 (2H, s); - 19F NMR (188MHz, CDCl3): δ -64.1 (2×CF3, s).

References

[1] Chemical Communications, 2005, # 3, p. 372 - 374
[2] Journal of the American Chemical Society, 2009, vol. 131, # 49, p. 17724 - 17725
[3] Journal of the American Chemical Society, 2010, vol. 132, # 3, p. 1127 - 1136
[4] Patent: US2010/209354, 2010, A1. Location in patent: Page/Page column 19
[5] Chemistry - A European Journal, 2010, vol. 16, # 36, p. 11028 - 11036

1,4-bis(trifluoromethyl)-2,5-dibromobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-bis(trifluoromethyl)-2,5-dibromobenzene Suppliers

China 35 United States 2 Global 37

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2375-96-4, 1,4-bis(trifluoromethyl)-2,5-dibromobenzeneRelated Search:

1,4-bis(trifluoromethyl)-2,5-dibromobenzene

1,4-dibromo-2,5-bis(trifluoromethyl)benzene

Benzene, 1,4-dibromo-2,5-bis(trifluoromethyl)-

2,5-Bis(trifluoromethyl)-1,4-dibromobenzene

1,4-Bis(trifluoromethyl)-2,5-dibromobenzene - [B94512]

2375-96-4