Mirogabalin

ChemicalBook > CAS DataBase List > Mirogabalin

Product Name: Mirogabalin
CAS No.: 1138245-13-2
Chemical Name: Mirogabalin
Synonyms: Asapiprant;2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid;DS5565;A200-0700;Milobarin;mirobalin;Miluobalin;Mirogabalin;Mirogabalin HCl;DS5565;A200-0700
CBNumber: CB23051612
Molecular Formula: C12H19NO2
Formula Weight: 209.28
MOL File: 1138245-13-2.mol

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Mirogabalin Property

Boiling point:: 357.5±15.0 °C(Predicted)
Density: 1.104±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:0.5(Max Conc. mg/mL);2.39(Max Conc. mM)
Ethanol:1.25(Max Conc. mg/mL);5.97(Max Conc. mM)
PBS (pH 7.2):0.5(Max Conc. mg/mL);2.39(Max Conc. mM)
Water:5.36(Max Conc. mg/mL);25.61(Max Conc. mM)
form: A crystalline solid
pka: 4.65±0.10(Predicted)
InChI: InChI=1S/C12H19NO2/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15)/t9-,10-,12-/m1/s1
InChIKey: FTBQORVNHOIASH-CKYFFXLPSA-N
SMILES: [C@]12([H])[C@]([H])([C@@](CN)(CC(O)=O)C1)C=C(CC)C2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22475
Product name: Mirogabalin
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 22475
Product name: Mirogabalin
Purity: ≥98%
Packaging: 5mg
Price: $152
Updated: 2024/03/01

TRC

Product number: M364940
Product name: Mirogabalin
Packaging: 1mg
Price: $140
Updated: 2021/12/16

TRC

Product number: M364940
Product name: Mirogabalin
Packaging: 2.5mg
Price: $305
Updated: 2021/12/16

ChemScene

Product number: CS-6008
Product name: Mirogabalin
Purity: 99.31%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

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Mirogabalin Chemical Properties,Usage,Production

Description

Mirogabalin is a calcium channel blocker with analgesic effects. It binds to the α₂δ-1 and α₂δ-2 subunits of voltage-dependent Ca²⁺ channels. Mirogabalin has potent and sustained analgesic effects (ED₅₀ = 2.5 mg/kg) in rats with diabetes induced by streptozotocin (STZ; ). Mirogabalin does not inhibit activities associated with CNS adverse effects of analgesics, such as rotarod performance (ID₅₀ = 9.4 mg/kg) or locomotor activity (ID₅₀ = 43.9 mg/kg), at its effective dose. Formulations containing mirogabalin are in clinical trials for diabetic peripheral neuropathic pain.

Uses

Mirogabalin is a two alpha2delta ligand which is investigated for the treatment of peripheral neuropathic pain, postherpetic neuralgia and fibromyalgia, showing promising results in patients with diabetic peripheral neuropathy.

brand name

Mirogabalin (brand name Tarlige; developmental code name DS-5565) is a gabapentinoid medication developed by Daiichi Sankyo.

Side effects

The most typical clinical adverse reactions of mirogabalin were dizziness (7.6%) and somnolence (5.1%). However, the occurrence rate was lower than with pregabalin, whose adverse effects were reported to include somnolence, balance disorder, fatigue, and peripheral edema, with an occurrence rate of 8.0%, 4.0%, 4.0%, and 4.0%, respectively[1].

Mode of action

Mirogabalin is an analog of the neurotransmitter, gamma-aminobutyric acid (GABA). It is a potent and specific ligand of the α2δ subunit of voltage-dependent Ca2+channels, which reduces calcium (Ca2+) influx and neurotransmission in dorsal root ganglia (DRGs), inhibiting neurotransmitter release in presynaptic neuron endings.

References

[1] Hui Tang. “The Clinical Application and Progress of Mirogabalin on Neuropathic Pain as a Novel Selective Gabapentinoids.” Mediators of Inflammation 2023 (2023): 4893436.

Mirogabalin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Mirogabalin manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Mirogabalin 1138245-13-2
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-07

Hebei Yanxi Chemical Co., Ltd.

Product: Mirogabalin 1138245-13-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100tons
Release date: 2023-08-16

1138245-13-2, MirogabalinRelated Search:

2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid

Mirogabalin

Asapiprant

[(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid

A200-0700

DS5565

DS5565;A200-0700

2-[(1R,5S,6S)-6-(aminomethyl)-3-ethyl-6-bicyclo[3.2.0]hept-3-enyl]acetic acid

MIROGABALIN; DS-5565

DS 5565;DS-5565;DS5565

Bicyclo[3.2.0]hept-3-ene-6-acetic acid, 6-(aminomethyl)-3-ethyl-, (1R,5S,6S)-

Miluobalin

Mirogabalin HCl

Milobarin

Mirogabalin Impurity

mirobalin

Mirogabalin free base

1138245-13-2

API

1138245-13-2