ChemicalBook > CAS DataBase List > N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide

Product Name
N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
CAS No.
1557267-42-1
Chemical Name
N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
Synonyms
CS-2348;Avitinib;Avi Tini;Abivertinib;Avitinib (AC0010);Avitinib free base;Avitinib Abivertinib;Avitinib, 10 mM in DMSO;Avitinib(AC0010/AC0010MA);N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
CBNumber
CB23051748
Molecular Formula
C26H26FN7O2
Formula Weight
487.53
MOL File
1557267-42-1.mol
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N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Property

Density 
1.365±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:30.0(Max Conc. mg/mL);61.53(Max Conc. mM)
form 
A crystalline solid
pka
12.48±0.50(Predicted)
color 
White to off-white
InChIKey
UOFYSRZSLXWIQB-UHFFFAOYSA-N
SMILES
C(NC1=CC=CC(OC2N=C(NC3=CC=C(N4CCN(C)CC4)C(F)=C3)N=C3NC=CC3=2)=C1)(=O)C=C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21387
Product name
Avitinib
Purity
≥98%
Packaging
1mg
Price
$41
Updated
2026/04/30
Cayman Chemical
Product number
21387
Product name
Avitinib
Purity
≥98%
Packaging
5mg
Price
$178
Updated
2026/04/30
Cayman Chemical
Product number
21387
Product name
Avitinib
Purity
≥98%
Packaging
10mg
Price
$312
Updated
2026/04/30
Cayman Chemical
Product number
21387
Product name
Avitinib
Purity
≥98%
Packaging
25mg
Price
$680
Updated
2026/04/30
Cayman Chemical
Product number
21387
Product name
Avitinib
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
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N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Chemical Properties,Usage,Production

Description

Avitinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR). It is selective for EGFR-active and T790M mutations, exhibiting a 298-fold increase in potency compared with wild-type EGFR. In a xenograft model, oral administration of 500 mg/kg avitinib was shown to result in complete remission of tumors with EGFR-active and T790M mutations.

Uses

Abivertinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR). Abivertinib synergistically strengthens anti-leukemia activity of venetoclax in acute myeloid leukemia in BTK-dependent manner.

in vivo

Avitinib (AC0010; 12.5-500 mg/kg; orally administration; once daily; for 14 days) inhibits EGFR-mutant tumor growth but not wild-type EGFR tumor growth in xenograft models over extended duration[1].

Animal Model:Nu/Nu nude mice (Six- to 8-week-old) injected with NCI-H1975 and A431 cells[1]
Dosage:12.5, 50, and 500 mg/kg
Administration:Orally administration; once daily; for 14 days
Result:Inhibited EGFR-mutant tumor growth but not wild-type EGFR tumor growth.

IC 50

EGFR L858R: 0.18 nM (IC50); EGFRT790M: 0.18 nM (IC50); EGFR (WT): 7.68 nM (IC50)

References

[1] XIAO XU. AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer Patients.[J]. Molecular Cancer Therapeutics, 2016, 15 11: 2586-2597. DOI: 10.1158/1535-7163.mct-16-0281

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Suppliers

China 87 India 1 United States 9 Global 97
Taizhou Nanfeng Pharmaceutical Research Institute
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nanfengpharma@126.co 18616377689
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nanfengpharma@126.com
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China
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Shanghai Boyle Chemical Co., Ltd.
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Fax
86-21-57758967
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sales@boylechem.com
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China
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BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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Suzhou Sino Rare Chemical Co., Ltd.
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0512-62857507
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+86-512-62857507
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sales@sinorarechem.com
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China
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997
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Bide Pharmatech Ltd.
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400-400-164-7117 18317119277
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+86-21-61629029
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product02@bidepharm.com
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China
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Shanghai Biolang biotechnology Co.,Ltd
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17764003753
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13669031409
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2326587775@qq.com
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China
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Shanghai Biolang biotechnology Co.,Ltd
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17764003753
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13669031409
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2326587775@qq.com
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Shanghai Send Pharmaceutical Technology Co., Ltd.
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50266790 18317173152
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QQ3382968513
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Hailey@shsendpharm.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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9803
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Shanghai Shanyuan pharmaceutical technology co., LTD
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021-31761238 13167072949
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021-31761238
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3146446224@qq.com
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China
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View Lastest Price from N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide manufacturers

Career Henan Chemical Co
Product
N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide 1557267-42-1
Price
US $1.00/KG
Min. Order
1g
Purity
98%
Supply Ability
200kgs
Release date
2020-01-09

1557267-42-1, N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamideRelated Search:

Cabozantinib

  • Avitinib
  • 2-Propenamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-
  • Avitinib(AC0010/AC0010MA)
  • Avitinib free base
  • Avitinib (AC0010)
  • N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
  • Avi Tini
  • Abivertinib
  • CS-2348
  • Epidermal growth factor receptor,Bruton tyrosine kinase,AC-0010,Avitinib,HER1,Inhibitor,EGFR,Btk,AC 0010,Abivertinib,inhibit,ErbB-1
  • N-{3-[(2-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
  • Avitinib Abivertinib
  • Avitinib, 10 mM in DMSO
  • 1557267-42-1
  • 557267-42-1