N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide

Product Name: N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
CAS No.: 1557267-42-1
Chemical Name: N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
Synonyms: CS-2348;Avitinib;Avi Tini;Abivertinib;Avitinib (AC0010);Avitinib free base;Avitinib Abivertinib;Avitinib(AC0010/AC0010MA);N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide;N-{3-[(2-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
CBNumber: CB23051748
Molecular Formula: C26H26FN7O2
Formula Weight: 487.53
MOL File: 1557267-42-1.mol

More

Less

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Property

Density: 1.365±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:30.0(Max Conc. mg/mL);61.53(Max Conc. mM)
form: A crystalline solid
pka: 12.48±0.50(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 21387
Product name: Avitinib
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21387
Product name: Avitinib
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 21387
Product name: Avitinib
Purity: ≥98%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 21387
Product name: Avitinib
Purity: ≥98%
Packaging: 25mg
Price: $618
Updated: 2024/03/01

AK Scientific

Product number: 4573DW
Product name: Abivertinib
Packaging: 25mg
Price: $785
Updated: 2021/12/16

More

Less

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Chemical Properties,Usage,Production

Description

Avitinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR). It is selective for EGFR-active and T790M mutations, exhibiting a 298-fold increase in potency compared with wild-type EGFR. In a xenograft model, oral administration of 500 mg/kg avitinib was shown to result in complete remission of tumors with EGFR-active and T790M mutations.

Uses

Abivertinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR). Abivertinib synergistically strengthens anti-leukemia activity of venetoclax in acute myeloid leukemia in BTK-dependent manner.

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Suppliers

China 71 India 1 United States 8 Global 80

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20000
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Suzhou Sino Rare Chemical Co., Ltd.

Tel: 0512-62857507
Fax: +86-512-62857507
Email: sales@sinorarechem.com
Country: China
ProdList: 965
Advantage: 58

Shanghai Biolang biotechnology Co.,Ltd

Tel: 17764003753
Fax: 13669031409
Email: 2326587775@qq.com
Country: China
ProdList: 188
Advantage: 55

Shanghai Biolang biotechnology Co.,Ltd

Tel: 17764003753
Fax: 13669031409
Email: 2326587775@qq.com
Country: China
ProdList: 188
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai Shanyuan pharmaceutical technology co., LTD

Tel: 021-31761238 13167072949
Fax: 021-31761238
Email: 3146446224@qq.com
Country: China
ProdList: 1636
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2986
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7295
Advantage: 58

More

Less

View Lastest Price from N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide manufacturers

Career Henan Chemical Co

Product: N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide 1557267-42-1
Price: US $1.00/KG
Min. Order: 1g
Purity: 98%
Supply Ability: 200kgs
Release date: 2020-01-09

1557267-42-1, N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamideRelated Search:

Cabozantinib

Avitinib

2-Propenamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-

Avitinib(AC0010/AC0010MA)

Avitinib free base

Avitinib (AC0010)

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide

Avi Tini

Abivertinib

CS-2348

Epidermal growth factor receptor,Bruton tyrosine kinase,AC-0010,Avitinib,HER1,Inhibitor,EGFR,Btk,AC 0010,Abivertinib,inhibit,ErbB-1

N-{3-[(2-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide

Avitinib Abivertinib

1557267-42-1

557267-42-1