Amino-PEG4-t-Boc-Hydrazide

Product Name: Amino-PEG4-t-Boc-Hydrazide
CAS No.: 1263047-17-1
Chemical Name: Amino-PEG4-t-Boc-Hydrazide
Synonyms: NH2-PEG4-HZ-Boc;Amino-PEG4-hydrazide-Boc;H2N-PEG4-CH2CH2CONHNHBoc;Amino-PEG4- Boc-Hydrazide;Amino-PEG4-t-Boc-Hydrazide;Amino-PEG4-N-Boc-hydrazide;Amino-dPEG??-t-boc-hydrazide (QBD-10041);2-BOC-Hydrozino 3-amino(peg4)propionamide;tert-Butyl 18-amino-4-oxo-7,10,13,16-tetraoxa-2,3-diazaoctadecan-1-oate;7,10,13,16-Tetraoxa-2,3-diazaoctadecanoic acid, 18-amino-4-oxo-, 1,1-dimethylethyl ester
CBNumber: CB23062319
Molecular Formula: C16H33N3O7
Formula Weight: 379.45
MOL File: 1263047-17-1.mol

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Amino-PEG4-t-Boc-Hydrazide Property

Density: 1.115±0.06 g/cm3(Predicted)
pka: 8.99±0.43(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: H289600
Product name: H2N-DPEG(4)-NHNH-Boc
Packaging: 100mg
Price: $350
Updated: 2021/12/16

Iris Biotech GmbH

Product number: PEG1335
Product name: H2N-dPEG(4)-NHNH-Boc
Packaging: 100mg
Price: $351
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: POL0002284
Product name: H2N-DPEG-(4)-NHNH-BOC
Purity: 95.00%
Packaging: 100MG
Price: $472.5
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1069
Product name: Amino-PEG4-t-Boc-Hydrazide
Packaging: 100mg
Price: $546
Updated: 2021/12/16

Iris Biotech GmbH

Product number: PEG1335
Product name: H2N-dPEG(4)-NHNH-Boc
Packaging: 1g
Price: $1296
Updated: 2021/12/16

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Amino-PEG4-t-Boc-Hydrazide Chemical Properties,Usage,Production

Description

Amino-PEG4-t-Boc-hydrazide is a PEG linker containing an amino group and a Boc-protected hydrazide. The hydrophilic PEG spacer increases solubility in aqueous media. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc can be deprotected under mild acidic conditions to form a reactive hydrazide, which can then be coupled with various carbonyl groups.

Uses

Amino-PEG4-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Amino-PEG4-t-Boc-Hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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Amino-PEG4-t-Boc-Hydrazide Suppliers

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1263047-17-1, Amino-PEG4-t-Boc-HydrazideRelated Search:

Amino-PEG4-t-Boc-Hydrazide

Amino-PEG4- Boc-Hydrazide

NH2-PEG4-HZ-Boc

H2N-PEG4-CH2CH2CONHNHBoc

Amino-PEG4-hydrazide-Boc

7,10,13,16-Tetraoxa-2,3-diazaoctadecanoic acid, 18-amino-4-oxo-, 1,1-dimethylethyl ester

2-BOC-Hydrozino 3-amino(peg4)propionamide

Amino-PEG4-N-Boc-hydrazide

H2N-PEG4-CH2CH2CONHNHBoc/7,10,13,16-Tetraoxa-2,3-diazaoctadecanoic acid, 18-amino-4-oxo-, 1,1-dimethylethyl ester

tert-Butyl 18-amino-4-oxo-7,10,13,16-tetraoxa-2,3-diazaoctadecan-1-oate

Amino-dPEG??-t-boc-hydrazide (QBD-10041)

1263047-17-1

C16H33N3O7

peg