Bis-PEG2-PFP ester

Product Name: Bis-PEG2-PFP ester
CAS No.: 1314378-18-1
Chemical Name: Bis-PEG2-PFP ester
Synonyms: PFP-PEG2-PFP;Bis-PEG2-PFP ester;PEG2 BIS-PFP ESTER;Bis-dPEG??-PFP ester;Ethyleneglycol-1,2-bis(pentafluorophenyl 3-oxypropionate);Propanoic acid, 3,3'-[1,2-ethanediylbis(oxy)]bis-, 1,1'-bis(2,3,4,5,6-pentafluorophenyl) ester;2,3,4,5,6-pentafluorophenyl 3-{2-[3-oxo-3-(2,3,4,5,6-pentafluorophenoxy)propoxy]ethoxy}propanoate
CBNumber: CB23062410
Molecular Formula: C20H12F10O6
Formula Weight: 538.29
MOL File: 1314378-18-1.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: P999863
Product name: Bis-PEG2-PFPEster
Packaging: 100mg
Price: $285
Updated: 2021/12/16

Iris Biotech GmbH

Product number: PEG4020
Product name: Pfp-PEG(2)-Pfp
Packaging: 100mg
Price: $351
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: LIN0000140
Product name: BIS-PEG2-PFP ESTER
Purity: 95.00%
Packaging: 5MG
Price: $436
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1275
Product name: Bis-PEG2-PFP ester
Packaging: 250mg
Price: $449
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: LIN0000140
Product name: BIS-PEG2-PFP ESTER
Purity: 95.00%
Packaging: 100MG
Price: $768
Updated: 2021/12/16

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Bis-PEG2-PFP ester Chemical Properties,Usage,Production

Description

Bis-PEG2-PFP ester is an amine reactive PEG linker. The two PFP ester moieties can form stable amide bonds and have been found to be very stable because they are less susceptible to undergo hydrolysis. The hydrophilic PEG linker increases the water solubility of the compound in aqueous envionments. Longer PEG chains tend to have enhanced water solubility properties compared to shorter PEG chains.

Uses

Bis-PEG2-PFP ester is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Bis-PEG2-PFP ester is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

IC 50

PEGs; Alkyl/ether; Non-cleavable Linker

References

[1] Matthew David DOROSKI, et al. Cytotoxic peptides and antibody drug conjugates thereof. WO2013072813A2.
[2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

Bis-PEG2-PFP ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Bis-PEG2-PFP ester Suppliers

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1314378-18-1, Bis-PEG2-PFP esterRelated Search:

PEG2 BIS-PFP ESTER

Bis-PEG2-PFP ester

PFP-PEG2-PFP

Propanoic acid, 3,3'-[1,2-ethanediylbis(oxy)]bis-, 1,1'-bis(2,3,4,5,6-pentafluorophenyl) ester

Ethyleneglycol-1,2-bis(pentafluorophenyl 3-oxypropionate)

Bis-dPEG??-PFP ester

2,3,4,5,6-pentafluorophenyl 3-{2-[3-oxo-3-(2,3,4,5,6-pentafluorophenoxy)propoxy]ethoxy}propanoate

1314378-18-1

C20H12F10O6