4-Chloro-5-fluoro-6-methoxy-2-methylpyrimidine
- Product Name
- 4-Chloro-5-fluoro-6-methoxy-2-methylpyrimidine
- CAS No.
- 1383976-40-6
- Chemical Name
- 4-Chloro-5-fluoro-6-methoxy-2-methylpyrimidine
- Synonyms
- 4-Chloro-5-fluoro-6-methoxy-2-methylpyrimidine;Pyrimidine, 4-chloro-5-fluoro-6-methoxy-2-methyl-
- CBNumber
- CB23065002
- Molecular Formula
- C6H6ClFN2O
- Formula Weight
- 176.58
- MOL File
- 1383976-40-6.mol
4-Chloro-5-fluoro-6-methoxy-2-methylpyrimidine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 0823EA
- Product name
- 4-Chloro-5-fluoro-6-methoxy-2-methylpyrimidine
- Packaging
- 250mg
- Price
- $138
- Updated
- 2021/12/16
- Product number
- PC535039
- Product name
- 4-Chloro-5-fluoro-6-methoxy-2-methylpyrimidine
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- PC535039
- Product name
- 4-Chloro-5-fluoro-6-methoxy-2-methylpyrimidine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $218
- Updated
- 2021/12/16
- Product number
- CM166166
- Product name
- 4-chloro-5-fluoro-6-methoxy-2-methylpyrimidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $660
- Updated
- 2021/12/16
- Product number
- A298440
- Product name
- 4-Chloro-5-fluoro-6-methoxy-2-methylpyrimidine
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $32
- Updated
- 2021/12/16
4-Chloro-5-fluoro-6-methoxy-2-methylpyrimidine Chemical Properties,Usage,Production
Synthesis
105806-13-1
124-41-4
1383976-40-6
Step 1a Synthesis of 4-chloro-5-fluoro-6-methoxy-2-methylpyrimidine: 3.21 g of sodium methanol was slowly added to 80 mL of tetrahydrofuran (THF) cooled solution containing 9.8 g of 2-methyl-4,6-dichloro-5-fluoropyrimidine, and the reaction system was maintained in an ice bath condition at a controlled temperature of 5 °C. After addition, the ice bath was removed. The reaction suspension was stirred continuously for 3 hours at room temperature. Upon completion of the reaction, the reaction mixture was again cooled to 5°C in an ice bath. Subsequently, 20 mL of water and 100 mL of ethyl acetate were added to the reaction system for extraction. After separation of the organic phase, it was dried with anhydrous magnesium sulfate, filtered, and the solvent was concentrated under reduced pressure to give 9 g of a colorless oily product, 4-chloro-5-fluoro-6-methoxy-2-methylpyrimidine. The product was purified by crystallization and characterized by the following data: mass spectrometry (Method A) showed retention time Tr (min) = 0.82; molecular ion peak [M+H]+: m/z 177.
References
[1] Patent: US2013/274253, 2013, A1. Location in patent: Paragraph 0798-0802
4-Chloro-5-fluoro-6-methoxy-2-methylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-5-fluoro-6-methoxy-2-methylpyrimidine Suppliers
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