Dimethyl 3-bromopyridine-2,6-dicarboxylate
- Product Name
- Dimethyl 3-bromopyridine-2,6-dicarboxylate
- CAS No.
- 316808-11-4
- Chemical Name
- Dimethyl 3-bromopyridine-2,6-dicarboxylate
- Synonyms
- Dimethyl 3-bromopyridine-2,6-dicarboxylate;2,6-pyridine-3-Bromo-Dicarboxylicacid Methyl ester;3-Bromo-2,6-pyridine Di Corboxilic acid methyl ester;3-bromo-pyridine-2,6-dicarboxylic acid dimethyl ester;2,6-Pyridinedicarboxylic acid, 3-bromo-, dimethyl ester;2,6-Pyridinedicarboxylic acid, 3-bromo-, 2,6-dimethyl ester
- CBNumber
- CB23065916
- Molecular Formula
- C9H8BrNO4
- Formula Weight
- 274.07
- MOL File
- 316808-11-4.mol
Dimethyl 3-bromopyridine-2,6-dicarboxylate Property
- Boiling point:
- 370.4±37.0 °C(Predicted)
- Density
- 1.569±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -3.06±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 316808114
- Product name
- Dimethyl3-bromopyridine-2,6-dicarboxylate
- Packaging
- 250mg
- Price
- $162.41
- Updated
- 2021/12/16
- Product number
- CM124896
- Product name
- dimethyl3-bromopyridine-2,6-dicarboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $316
- Updated
- 2021/12/16
- Product number
- CD11146497
- Product name
- Dimethyl3-bromopyridine-2,6-dicarboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $335
- Updated
- 2021/12/16
- Product number
- 316808114
- Product name
- Dimethyl3-bromopyridine-2,6-dicarboxylate
- Packaging
- 1g
- Price
- $364.56
- Updated
- 2021/12/16
- Product number
- CM124896
- Product name
- dimethyl3-bromopyridine-2,6-dicarboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $948
- Updated
- 2021/12/16
Dimethyl 3-bromopyridine-2,6-dicarboxylate Chemical Properties,Usage,Production
Synthesis
67-56-1
316808-10-3
316808-11-4
Concentrated hydrochloric acid was slowly added to a stirred solution of 3-bromopyridine-2,6-dicarboxylic acid (20.0 kg, 81.29 mol) in methanol (100 L). Subsequently, sulfuric acid (4.4 L) was added dropwise over 30 min. The reaction mixture was heated to 65 °C and maintained at this temperature for 5 h (reaction progress was monitored by TLC). Upon completion of the reaction, the mixture was cooled to room temperature and alkalized by careful addition of an aqueous NaHCO3 solution prepared from sodium bicarbonate (10 kg) and water (120 L) and further diluted with water (120 L). The resulting white solid was collected by filtration, washed with plenty of water and subsequently oven dried at 40 °C to afford dimethyl 3-bromopyridine-2,6-dicarboxylate (9.2 kg, 41.3% yield) as a white solid.1HNMR (300 MHz, DMSO-d6) δ 8.47 (d, J = 8.4 Hz, 1H), 8.08 (dd, J = 4.5, 8.4 Hz, 1H), 3.95 (s, 3H), 3.91 (s, 3H); MS (ES+) m/z 570.6 (2M + Na)+; Elemental analysis (C9H8BrNO4) Calculated value: C, 39.44; H, 2.94; Br, 29.15; N, 5.1; Measured value: C, 39.52; H, 2.92; Br, 29.28; N, 5.03.
References
[1] Patent: WO2016/29216, 2016, A2. Location in patent: Page/Page column 84
[2] Patent: WO2018/81513, 2018, A1. Location in patent: Page/Page column 65
Dimethyl 3-bromopyridine-2,6-dicarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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