BGG463

Product Name: BGG463
CAS No.: 890129-26-7
Chemical Name: BGG463
Synonyms: K 0859;BGG463;CS-2570;K 03859;BGG463 (K03859);BGG 463;BGG-463;BGG463, 10 mM in DMSO;BGG463,K03859,inhibit,CDK,Cyclin dependent kinase,Inhibitor,K 03859,BGG-463,BGG 463,K-03859;6-((6-Acetamidopyrimidin-4-yl)oxy)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-1-naphthamide;6-(6-acetamidopyrimidin-4-yl)oxy-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]naphthalene-1-carboxamide
CBNumber: CB23067536
Molecular Formula: C30H29F3N6O3
Formula Weight: 578.58
MOL File: 890129-26-7.mol

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BGG463 Property

Boiling point:: 669.0±55.0 °C(Predicted)
Density: 1.366±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 125 mg/mL (216.05 mM)
pka: 12.06±0.70(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0019751
Product name: BGG463
Purity: >98.0%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: SYN1226
Product name: BGG463
Packaging: 1mg
Price: $210
Updated: 2021/12/16

ChemScene

Product number: CS-0019751
Product name: BGG463
Purity: >98.0%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

Adipogen Life Sciences

Product number: SYN-1226-M005
Product name: BGG463
Purity: ≥95%(HPLC)
Packaging: 5mg
Price: $421
Updated: 2021/12/16

ChemScene

Product number: CS-0019751
Product name: BGG463
Purity: >98.0%
Packaging: 25mg
Price: $450
Updated: 2021/12/16

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BGG463 Chemical Properties,Usage,Production

Uses

BGG463 (K03859) is an orally active type II CDK2 inhibitor[1].

Biological Activity

BGG463 (K03859) is an orally active inhibitor of type II CDK2.

in vitro

BGG463 potently inhibits T315I BCR–ABL autophosphorylation and shows good oral efficacy in mouse models of CML.

target

CDK2

IC 50

CDK2

References

[1] Alexander LT, et al. Type II Inhibitors Targeting CDK2. ACS Chem Biol. 2015 Sep 18;10(9):2116-25. DOI:10.1021/acschembio.5b00398
[2] Jones K, et al. Cancer Drug Discovery 2010: from molecules to medicine. Expert Rev Clin Pharmacol. 2010 Sep;3(5):613-5. DOI:10.1586/ecp.10.50

BGG463 Preparation Products And Raw materials

Raw materials

Preparation Products

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BGG463 Suppliers

China 35 United Kingdom 1 United States 5 Global 41

Shanghai Lollane Biological Technology Co.,Ltd.

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890129-26-7, BGG463Related Search:

6-(6-acetamidopyrimidin-4-yl)oxy-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]naphthalene-1-carboxamide

BGG463

K 0859

CS-2570

BGG 463;BGG-463

BGG463 (K03859)

K 03859

BGG463,K03859,inhibit,CDK,Cyclin dependent kinase,Inhibitor,K 03859,BGG-463,BGG 463,K-03859

1-Naphthalenecarboxamide, 6-[[6-(acetylamino)-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-

6-((6-Acetamidopyrimidin-4-yl)oxy)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-1-naphthamide

BGG463, 10 mM in DMSO

890129-26-7

C30H29F3N6O3