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WWL113

Product Name
WWL113
CAS No.
947669-86-5
Chemical Name
WWL113
Synonyms
WWL113;WWL-113,WWL113;AKIIPHDGVCFVCC-UHFFFAOYSA-N;ethyl 4-[4-[methyl-[(3-pyridin-4-ylphenyl)methyl]carbamoyl]oxyphenyl]benzoate;4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester;[1,1'-Biphenyl]-4-carboxylic acid, 4'-[[[methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-, ethyl ester
CBNumber
CB23067596
Molecular Formula
C29H26N2O4
Formula Weight
466.52774
MOL File
947669-86-5.mol
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WWL113 Property

Boiling point:
630.9±55.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 15 mg/ml; Ethanol: 0.1 mg/ml
form 
A crystalline solid
pka
5.18±0.26(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16181
Product name
WWL113
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
16181
Product name
WWL113
Purity
≥98%
Packaging
5mg
Price
$90
Updated
2024/03/01
Cayman Chemical
Product number
16181
Product name
WWL113
Purity
≥98%
Packaging
10mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
16181
Product name
WWL113
Purity
≥98%
Packaging
25mg
Price
$353
Updated
2024/03/01
Usbiological
Product number
257115
Product name
WWL 113
Packaging
10mg
Price
$460
Updated
2021/12/16
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WWL113 Chemical Properties,Usage,Production

Uses

WWL113 is a selective inhibitor of carboxylesterase 3 (Ces3) without significantly affecting several related enzymes. It significantly reduces basal lipolysis in adipocytes.

Definition

ChEBI: WWL113 is a member of biphenyls.

Biological Activity

WWL113 is an inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids th at can deposit ectopically in tissues. WWL113 treatment resulted in major improvement of multiple features of metabolic syndrome and ameliorated obesity-diabetes in mice with lowered levels of nonesterified free fatty acids (NEFAs), triglycerides (TGs), total cholesterol and fasted glucose as well as enhanced glucose tolerance after three weeks of treatment. WWL113 inhibits Ces3 with an IC50 of 120 nM and also the closely related Ces1f with an IC50 of 100 nM. WWL113 inhibits mouse recombinant Ces1, Ces1c, and Abhd6 at 10 μM.

WWL113 Preparation Products And Raw materials

Raw materials

Preparation Products

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WWL113 Suppliers

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947669-86-5, WWL113Related Search:

WWL 154 WWL229 WWL123 WWL70 4-[2-(cyclopropanecarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-yl]benzoic acid

  • WWL113
  • AKIIPHDGVCFVCC-UHFFFAOYSA-N
  • ethyl 4-[4-[methyl-[(3-pyridin-4-ylphenyl)methyl]carbamoyl]oxyphenyl]benzoate
  • 4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester
  • WWL-113,WWL113
  • [1,1'-Biphenyl]-4-carboxylic acid, 4'-[[[methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-, ethyl ester
  • 947669-86-5