PODOCARPIC ACID

Product Name: PODOCARPIC ACID
CAS No.: 5947-49-9
Chemical Name: PODOCARPIC ACID
Synonyms: Nsc 231784;PODOCARPIC ACID;Einecs 227-706-3;Podocarpic acid 98%;Podocarpic acid, >99%;Podocarpic acid, 10 mM in DMSO;12-HYDROXYPODOCARPA-8,11,13-TRIEN-16-OIC ACID;Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy- (van) (8ci);1 4A-DIMETHYL-6-HYDROXY-1 2 3,4A 9 10 10A-OCTAHYDRO-1-PHENANTHRENECARBOXYLIC ACID;inhibit,Podocarpic acid,Transient receptor potential channels,TRP Channel,Inhibitor
CBNumber: CB2309721
Molecular Formula: C17H22O3
Formula Weight: 274.35
MOL File: 5947-49-9.mol

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PODOCARPIC ACID Property

Melting point:: 193-196 °C (lit.)
alpha: 20546 +165° (c = 4 in abs ethanol)
Boiling point:: 449.6±45.0 °C(Predicted)
Density: 1.182±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 100 mg/mL (364.50 mM)
pka: 4.66±0.40(Predicted)
form: Solid
color: White to off-white
optical activity: [α]20/D +133°, c = 4 in ethanol
Merck: 13,7625

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 119792
Product name: Podocarpic acid
Purity: 98%
Packaging: 100mg
Price: $96.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 119792
Product name: Podocarpic acid
Purity: 98%
Packaging: 1g
Price: $530
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0003883
Product name: PODOCARPIC ACID
Purity: 95.00%
Packaging: 100MG
Price: $610.62
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003883
Product name: PODOCARPIC ACID
Purity: 95.00%
Packaging: 1G
Price: $930.78
Updated: 2021/12/16

ChemScene

Product number: CS-6114
Product name: Podocarpic acid
Purity: 99.56%
Packaging: 50mg
Price: $216
Updated: 2021/12/16

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PODOCARPIC ACID Chemical Properties,Usage,Production

Uses

Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.

Definition

ChEBI: An abietane diterpenoid lacking the isopropyl substituent with an aromatic C-ring and a hydroxy group at the 12-position.

in vivo

Podocarpic acid activates SKN-1 in C. elegans, similar to known Nrf2 activators such as α-lipoic acid (LA). Podocarpic acid- or LA-induced SKN-1 activation also requires TRPodocarpic acid-1: trPodocarpic acid-1 knockdown in glod-4;gst-4p::gfp animals reduces expression of gst-4 to wild-type levels. A and LA supplementation results in a robust Ca²⁺ flux, which is significantly reduces when the Ca²⁺-impermeable TRPodocarpic acid-1E1018A channel is present, suggesting that TRPodocarpic acid-1 activation is key for these drugs' function. Finally, Podocarpic acid and LA alleviate the Podocarpic acidthogenic phenotypes of glod-4 animals by reverting the high endogenous MGO and GO to almost wild-type-like levels^[1].

References

[1] Baraka HN. Microbial transformation of podocarpic acid and evaluation of transformation products for antioxidant activity. Planta Med. 2010 May;76(8):815-7. DOI:10.1055/s-0029-1240738
[2] Singh S, et al. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2824-8. DOI:10.1016/j.bmcl.2005.03.100

PODOCARPIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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PODOCARPIC ACID Suppliers

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5947-49-9, PODOCARPIC ACIDRelated Search:

PODOCARPIC ACID(P) 1-METHYL-1-CYCLOHEXANECARBOXYLIC ACID PODOCARPIC ACID 9-PHENYL-NONANOIC ACID 2-METHYL-4-PHENYLPENTANAL 5-(4-HYDROXYPHENYL)PENTANOIC ACID [1S,(+)]-1,2,3,4,4a,9,10,10aα-Octahydro-6-hydroxy-1,4aβ-dimethyl-7-(1-methylethyl)-1β-phenanthrenecarboxylic acid 4ALPHA-METHYL-1,2,3,4,9,10-HEXAHYDROPHENANTHRENE 6-Phenylhexanoic acid 4,8-DIMETHYL-1-PHENYLNONANE 5-Phenylvaleric acid

(1S,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethylphenanthrene-1-carboxylic acid

1,4-alpha-Dimethyl-6-hydroxy-1,2,3,4-alpha-9,10,10-alpha-octahydro-1-phenanthrenecarboxylicacid

1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-, (1S,4aS,10aR)-

1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy -1,4a-dimethyl-, (1S-(1alpha,4aalpha,10abeta))- (9CI)

(1S)-1,2,3,4,4aβ,9,10,10aα-Octahydro-6-hydroxy-1,4a-dimethyl-1-phenanthrenecarboxylic acid

(1S)-1,4aβ-Dimethyl-6-hydroxy-1,2,3,4,4a,9,10,10aα-octahydrophenanthrene-1β-carboxylic acid

[1S,(+)]-1,2,3,4,4a,9,10,10aα-Octahydro-6-hydroxy-1,4aβ-dimethyl-1β-phenanthrenecarboxylic acid

(1R)-1,4aα-Dimethyl-6-hydroxy-1,2,3,4,4a,9,10,10aβ-octahydrophenanthrene-1α-carboxylic acid

1,2,3,4,4a,9,10,10aβ-Octahydro-6-hydroxy-1,4aα-dimethyl-1α-phenanthrenecarboxylic acid

Einecs 227-706-3

Nsc 231784

Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy- (van) (8ci)

Podocarpic acid 98%

Podocarpic acid, >99%

PODOCARPIC ACID

1 4A-DIMETHYL-6-HYDROXY-1 2 3,4A 9 10 10A-OCTAHYDRO-1-PHENANTHRENECARBOXYLIC ACID

12-HYDROXYPODOCARPA-8,11,13-TRIEN-16-OIC ACID

inhibit,Podocarpic acid,Transient receptor potential channels,TRP Channel,Inhibitor

Podocarpic acid, 10 mM in DMSO

5947-49-9

Chiral Building Blocks

Asymmetric Synthesis

Complex Molecules

Asymmetric Synthesis

Chiral Building Blocks

Complex Molecules