tert-butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate

Product Name: tert-butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate
CAS No.: 255051-62-8
Chemical Name: tert-butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate
Synonyms: 2-(1-Boc-piperidin-4-yl)phenyl]methanol;tert-butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate;tert-Butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate;tert-butyl 4-[2-(hydroxymethyl)phenyl]piperidine-1-carboxylate - [B85957];1-Piperidinecarboxylic acid, 4-[2-(hydroxymethyl)phenyl]-, 1,1-dimethylethyl ester
CBNumber: CB23105245
Molecular Formula: C17H25NO3
Formula Weight: 291.39
MOL File: 255051-62-8.mol

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tert-butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate Property

Boiling point:: 420.8±40.0 °C(Predicted)
Density: 1.109±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.32±0.10(Predicted)
form: powder
SMILES: O=C(N(CC1)CCC1C2=C(CO)C=CC=C2)OC(C)(C)C

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 917168
Product name: tert-Butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate
Purity: ≥95%
Packaging: 100MG
Price: $183
Updated: 2023/06/20

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tert-butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

tert-Butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

reaction suitability

reagent type: linker

tert-butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate Suppliers

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255051-62-8, tert-butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylateRelated Search:

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tert-butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate

1-Piperidinecarboxylic acid, 4-[2-(hydroxymethyl)phenyl]-, 1,1-dimethylethyl ester

<i>tert</i>-Butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate

2-(1-Boc-piperidin-4-yl)phenyl]methanol

tert-butyl 4-[2-(hydroxymethyl)phenyl]piperidine-1-carboxylate - [B85957]

255051-62-8