Ethyl 7-bromo-2,2-dimethylheptanoate
- Product Name
- Ethyl 7-bromo-2,2-dimethylheptanoate
- CAS No.
- 123469-92-1
- Chemical Name
- Ethyl 7-bromo-2,2-dimethylheptanoate
- Synonyms
- ethyl 7-bromo-2,2-dimethylheptanoate;ETC-1002 intermediate 2;Intermediate of bepridil;Bempedoic Acid Impurity 9;Bepidoic acid impurity 11;Bempedoic acid intermediate;Bempedoic Acid Intermediates;7-bromo-2,2-dimethylheptanoate;ethyl-2,2-dimethyl-7-bromoheptanoate;7-Bromo-2,2-dimethylheptanoic acid ethyl ester
- CBNumber
- CB23105876
- Molecular Formula
- C11H21BrO2
- Formula Weight
- 265.19
- MOL File
- 123469-92-1.mol
Ethyl 7-bromo-2,2-dimethylheptanoate Property
- Boiling point:
- 106-108 °C(Press: 0.01 Torr)
- Density
- 1.169±0.06 g/cm3(Predicted)
- vapor pressure
- 0.0±0.6 mmHg at 25°C
- refractive index
- 1.463
- Flash point:
- 146.4±13.0 °C
- storage temp.
- Store at room temperature
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C11H21BrO2/c1-4-14-10(13)11(2,3)8-6-5-7-9-12/h4-9H2,1-3H3
- InChIKey
- SYRIIFZUZOIRNU-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)C(C)(C)CCCCCBr
- LogP
- 3.92
Safety
- RIDADR
- UN2810
- HazardClass
- 6.1
- HS Code
- 2915907098
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CS-M3640
- Product name
- 7-Bromo-2,2-dimethylheptanoicacidethylester
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- CS-M3640
- Product name
- 7-Bromo-2,2-dimethylheptanoicacidethylester
- Packaging
- 5g
- Price
- $205
- Updated
- 2021/12/16
- Product number
- A606282
- Product name
- Ethyl7-bromo-2,2-dimethylheptanoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $6
- Updated
- 2021/12/16
- Product number
- A606282
- Product name
- Ethyl7-bromo-2,2-dimethylheptanoate
- Purity
- 97%
- Packaging
- 5g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- A606282
- Product name
- Ethyl7-bromo-2,2-dimethylheptanoate
- Purity
- 97%
- Packaging
- 25g
- Price
- $63
- Updated
- 2021/12/16
Ethyl 7-bromo-2,2-dimethylheptanoate Chemical Properties,Usage,Production
Description
Ethyl 7-bromo-2,2-dimethylheptanoate is an important raw material in the synthesis route of bepetidic acid. Bempedoic acid, whose chemical name is 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid, also known as ETC-1002, is a new type of lipid developed by the American EsperionTherapeutic company Quality regulation small molecule drugs. As one of the company's main drug candidates, its targets are liver adenosine triphosphate-citrate lyase (ACL) and adenosine monophosphate-activated protein kinase (AMPK).
Uses
Ethyl-2,2-dimethyl-7-bromoheptanoate can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and chemical production processes.
Synthesis
Ethyl 7-bromo-2,2-dimethylheptanoate is obtained from ethyl isobutyrate and 1,5-dibromopentane as starting materials, undergoing a reaction with lithium diisopropylamide (LDA) at low temperatures.
Synthesis
The specific embodiment of the present invention is as follows: prepare 19.4g (167mmol) of ethyl isobutyrate in 216mL solution of tetrahydrofuran with a mass concentration of 10%, connect to metering pump 1; prepare 84mL (168mmol) of 2.0M n-butyllithium solution, connect to meter Pump 2; configure 1,5-dibromopentane 80.0g (348mmol) tetrahydrofuran 100mL solution, mass concentration is 63%, connected to metering pump 3.Configure 300mL of 1N hydrochloric acid solution and connect to metering pump 4.Set continuous flow precooler 1, the circulating temperature is 0, and reach stability; set continuous flow precooler 2, the circulating temperature is 0, and reach stability; set continuous flow precooler 3, and the circulating temperature is 0, and reach stability; set continuous flow precooler 4, cycle temperature is 0, and reach stability;Set the flow rate of metering pump 1 to 65.0ml/min, set the flow rate of metering pump 2 to 25.0ml/min, set the flow rate of metering pump 3 to 30.0ml/min, and set the flow rate of metering pump 4 to 90.0ml/min.Turn on the metering pump 1 and metering pump 2 at the same time. After 60s of operation, turn on the metering pump 3, and after 60s of operation, turn on the metering pump 4 to collect the outflowing reaction liquid in the storage tank.After the operation is completed, separate the liquids, collect the upper organic phase, concentrate under reduced pressure at P=-0.08MPa, T=45C to remove low-boiling solvents, and then rectify under reduced pressure at P=5mmHg and T=70C to obtain 38.4 g.The obtained product is a colorless liquid with a GC purity of 98.6% and a yield of 87%.
Ethyl 7-bromo-2,2-dimethylheptanoate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 7-bromo-2,2-dimethylheptanoate Suppliers
- Tel
- 028-82666846 18080826311
- Fax
- QQ 2917178106
- sales@astatech.com.cn
- Country
- China
- ProdList
- 499
- Advantage
- 58
- Tel
- 13626608877
- sales@pancare.com.cn
- Country
- China
- ProdList
- 4
- Advantage
- 58
- Tel
- 021-36680027 15821745250
- fengqiang@famobiotech.com
- Country
- China
- ProdList
- 588
- Advantage
- 56
- Tel
- 18519331287; 18519331287
- 1751713684@qq.com
- Country
- China
- ProdList
- 224
- Advantage
- 58
- Tel
- 0432-62601618 13756693631
- Fax
- 0432-62601618
- wangjiaqi@lianben.com
- Country
- China
- ProdList
- 46
- Advantage
- 58
- Tel
- 053182375892 15098789112
- Fax
- 0531-82375893
- haiyao@jndxj.com
- Country
- China
- ProdList
- 1634
- Advantage
- 58
- Tel
- 18501091076 18501091076
- 57715449@qq.com
- Country
- China
- ProdList
- 70
- Advantage
- 58
- Tel
- 19159025340
- sunrui@hfshly.com
- Country
- China
- ProdList
- 486
- Advantage
- 58
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44802
- Advantage
- 61
View Lastest Price from Ethyl 7-bromo-2,2-dimethylheptanoate manufacturers
- Product
- Ethyl-2,2-dimethyl-7-bromoheptanoate 123469-92-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 97.0-99.0%min GC
- Supply Ability
- 5-10tons/year
- Release date
- 2022-01-07
- Product
- ethyl-2,2-dimethyl-7-bromoheptanoate 123469-92-1
- Price
- US $8.00-2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-24
- Product
- ethyl-2,2-dimethyl-7-bromoheptanoate 123469-92-1
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 100kg； 500kg
- Release date
- 2019-12-24