ethyl-2,2-dimethyl-7-bromoheptanoate

Product Name: ethyl-2,2-dimethyl-7-bromoheptanoate
CAS No.: 123469-92-1
Chemical Name: ethyl-2,2-dimethyl-7-bromoheptanoate
Synonyms: ethyl 7-bromo-2,2-dimethylheptanoate;ETC-1002 intermediate 2;Bempedoic Acid Impurity 9;Bempedoic acid intermediate;Bempedoic Acid Intermediates;7-bromo-2,2-dimethylheptanoate;ethyl-2,2-dimethyl-7-bromoheptanoate;7-Bromo-2,2-dimethylheptanoic acid ethyl ester;Heptanoic acid, 7-bromo-2,2-dimethyl-, ethyl ester;Toulene-4-Sulfonic Acid 2-Thiophne -2-Yl Ethyl Ester
CBNumber: CB23105876
Molecular Formula: C11H21BrO2
Formula Weight: 265.19
MOL File: 123469-92-1.mol

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ethyl-2,2-dimethyl-7-bromoheptanoate Property

Boiling point:: 106-108 °C(Press: 0.01 Torr)
Density: 1.169±0.06 g/cm3(Predicted)
InChI: InChI=1S/C11H21BrO2/c1-4-14-10(13)11(2,3)8-6-5-7-9-12/h4-9H2,1-3H3
InChIKey: SYRIIFZUZOIRNU-UHFFFAOYSA-N
SMILES: C(OCC)(=O)C(C)(C)CCCCCBr

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Safety

HS Code: 2915907098

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-M3640
Product name: 7-Bromo-2,2-dimethylheptanoicacidethylester
Packaging: 1g
Price: $68
Updated: 2021/12/16

ChemScene

Product number: CS-M3640
Product name: 7-Bromo-2,2-dimethylheptanoicacidethylester
Packaging: 5g
Price: $205
Updated: 2021/12/16

Chemenu

Product number: CM329574
Product name: ethyl7-bromo-2,2-dimethylheptanoate
Purity: 95%+
Packaging: 500g
Price: $1840
Updated: 2021/12/16

Ambeed

Product number: A606282
Product name: Ethyl7-bromo-2,2-dimethylheptanoate
Purity: 97%
Packaging: 1g
Price: $6
Updated: 2021/12/16

Ambeed

Product number: A606282
Product name: Ethyl7-bromo-2,2-dimethylheptanoate
Purity: 97%
Packaging: 5g
Price: $22
Updated: 2021/12/16

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ethyl-2,2-dimethyl-7-bromoheptanoate Chemical Properties,Usage,Production

Description

Ethyl 7-bromo-2,2-dimethylheptanoate is an important raw material in the synthesis route of bepetidic acid. Bempedoic acid, whose chemical name is 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid, also known as ETC-1002, is a new type of lipid developed by the American EsperionTherapeutic company Quality regulation small molecule drugs. As one of the company's main drug candidates, its targets are liver adenosine triphosphate-citrate lyase (ACL) and adenosine monophosphate-activated protein kinase (AMPK).

Uses

Ethyl-2,2-dimethyl-7-bromoheptanoate can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and chemical production processes.

Synthesis

The specific embodiment of the present invention is as follows: prepare 19.4g (167mmol) of ethyl isobutyrate in 216mL solution of tetrahydrofuran with a mass concentration of 10%, connect to metering pump 1; prepare 84mL (168mmol) of 2.0M n-butyllithium solution, connect to meter Pump 2; configure 1,5-dibromopentane 80.0g (348mmol) tetrahydrofuran 100mL solution, mass concentration is 63%, connected to metering pump 3.Configure 300mL of 1N hydrochloric acid solution and connect to metering pump 4.Set continuous flow precooler 1, the circulating temperature is 0, and reach stability; set continuous flow precooler 2, the circulating temperature is 0, and reach stability; set continuous flow precooler 3, and the circulating temperature is 0, and reach stability; set continuous flow precooler 4, cycle temperature is 0, and reach stability;Set the flow rate of metering pump 1 to 65.0ml/min, set the flow rate of metering pump 2 to 25.0ml/min, set the flow rate of metering pump 3 to 30.0ml/min, and set the flow rate of metering pump 4 to 90.0ml/min.Turn on the metering pump 1 and metering pump 2 at the same time. After 60s of operation, turn on the metering pump 3, and after 60s of operation, turn on the metering pump 4 to collect the outflowing reaction liquid in the storage tank.After the operation is completed, separate the liquids, collect the upper organic phase, concentrate under reduced pressure at P=-0.08MPa, T=45??C to remove low-boiling solvents, and then rectify under reduced pressure at P=5mmHg and T=70??C to obtain 38.4 g.The obtained product is a colorless liquid with a GC purity of 98.6% and a yield of 87%.

ethyl-2,2-dimethyl-7-bromoheptanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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ethyl-2,2-dimethyl-7-bromoheptanoate Suppliers

China 133 India 15 United States 1 Global 149

China fortune way company

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Shanghai Boyle Chemical Co., Ltd.

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Energy Chemical

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View Lastest Price from ethyl-2,2-dimethyl-7-bromoheptanoate manufacturers

AstaTech(Chengdu) Biopharmaceutical Corp.

Product: Ethyl-2,2-dimethyl-7-bromoheptanoate 123469-92-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 97.0-99.0%min GC
Supply Ability: 5-10tons/year
Release date: 2022-01-07

Henan Fengda Chemical Co., Ltd

Product: ethyl-2,2-dimethyl-7-bromoheptanoate 123469-92-1
Price: US $8.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-24

Henan Aochuang Chemical Co.,Ltd.

Product: ethyl-2,2-dimethyl-7-bromoheptanoate 123469-92-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-28

123469-92-1, ethyl-2,2-dimethyl-7-bromoheptanoateRelated Search:

DL-Ethyl 2-bromobutyrate Heptanoic acid Ethyl 4-bromobenzoate Ethyl 2-bromoisobutyrate Ethyl Hexanoate ETHYL STEARATE

ethyl-2,2-dimethyl-7-bromoheptanoate

7-Bromo-2,2-dimethylheptanoic acid ethyl ester

ETC-1002 intermediate 2

ethyl 7-bromo-2,2-dimethylheptanoate

Heptanoic acid, 7-bromo-2,2-dimethyl-, ethyl ester

Bempedoic Acid Impurity 9

Bempedoic acid intermediate

7-bromo-2,2-dimethylheptanoate

2,14-dimethyl-8-oxopentadecane-2,7,9,14-tetracarboxylic acid

Bempedoic Acid Intermediates

Toulene-4-Sulfonic Acid 2-Thiophne -2-Yl Ethyl Ester

123469-92-1