ADENYLOSUCCINIC ACID

Product Name: ADENYLOSUCCINIC ACID
CAS No.: 19046-78-7
Chemical Name: ADENYLOSUCCINIC ACID
Synonyms: C03794;Aspartyl-AMP;aspartyl adenylate;adenylosuccnic acid;Adenylsuccinic acid;ADENYLOSUCCINIC ACID;ADENYLOSUCCINIC ACID HYDRATE;adenylosuccinic acid free acid;L-Aspartic acid 4-(5'-adenylyl) ester;N-[9-(5-O-Phosphono-β-D-ribofuranosyl)-9H-purin-6-yl]-L-aspartic acid
CBNumber: CB2311379
Molecular Formula: C14H18N5O11P
Formula Weight: 463.29
MOL File: 19046-78-7.mol

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ADENYLOSUCCINIC ACID Property

Boiling point:: 921.9±75.0 °C(Predicted)
Density: 2.19±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMF: 20 mg/ml
DMSO: 20 mg/ml
Ethanol: Partially solublePBS (pH 7.2): 10 mg/ml
pka: 1.86±0.10(Predicted)
form: powder
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29696
Product name: Adenylosuccinic Acid
Packaging: 10mg
Price: $126
Updated: 2024/03/01

Cayman Chemical

Product number: 29696
Product name: Adenylosuccinic Acid
Packaging: 100mg
Price: $600
Updated: 2021/12/16

Cayman Chemical

Product number: 29696
Product name: Adenylosuccinic Acid
Packaging: 25mg
Price: $257
Updated: 2024/03/01

Cayman Chemical

Product number: 29696
Product name: Adenylosuccinic Acid
Packaging: 50mg
Price: $474
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: MTB0002395
Product name: ADENYLOSUCCINIC ACID
Purity: 95.00%
Packaging: 25MG
Price: $715.52
Updated: 2021/12/16

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ADENYLOSUCCINIC ACID Chemical Properties,Usage,Production

Uses

Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD)[1].

Definition

ChEBI: The N6-(1,2-dicarboxyethyl) derivative of adenosine 5'-monophosphate.

in vivo

Adenylosuccinic acid (oral administration; 3-3000 μg/mL; 6 weeks) significantly improves the features of murine DMD, it decreases the number of centronucleated fibres, lipid accumulation, connective tissue infiltration and Ca²⁺?content of mdx tibialis anterior^[1].

Animal Model:	C57Bl/10ScSn (normal wild-type strain; Con)?and C57Bl/10mdx?(mdx) mice^[1]
Dosage:	3?μg/mL, 30?μg/mL, 300?μg/mL, 3000 μg/mL
Administration:	3?μg/mL for 3 days and 30?μg/mL for the next 4 days, and 300?μg/mL for one week, and then 3000?μg/mL for 6 weeks
Result:	Ameliorated the symptoms of murine duchenne muscular dystrophy.

IC 50

Human Endogenous Metabolite

References

[1] Timpani CA, et al. Adenylosuccinic acid therapy ameliorates murine Duchenne Muscular Dystrophy.Sci Rep. 2020 Jan 24;10(1):1125. DOI:10.1038/s41598-020-57610-w
[2] WAARDE A V. OPERATION OF THE PURINE NUCLEOTIDE CYCLE IN ANIMAL TISSUES[J]. Biological Reviews, 1988, 63 2: 259-298. DOI: 10.1111/j.1469-185x.1988.tb00632.x
[3] HALONEN J, NEDERGAARD J. Adenosine 5?-Monophosphate Is a Selective Inhibitor of the Brown Adipocyte Nonselective Cation Channel[J]. The Journal of Membrane Biology, 2002, 14 1: 0. DOI: 10.1007/s00232-001-0184-0
[4] Y. NISHIDA T. M. Contractile effect of succinylpurines on guinea pig uterus[J]. General Pharmacology-the Vascular System, 1988, 19 2: Pages 277-279. DOI: 10.1016/0306-3623(88)90076-6
[5] JESSICA R GOODING. Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.[J]. Cell reports, 2015, 13 1: 157-167. DOI: 10.1016/j.celrep.2015.08.072
[6] TARAKA R. DONTI . Diagnosis of adenylosuccinate lyase deficiency by metabolomic profiling in plasma reveals a phenotypic spectrum[J]. Molecular Genetics and Metabolism Reports, 2016, 8: Pages 61-66. DOI: 10.1016/j.ymgmr.2016.07.007

ADENYLOSUCCINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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ADENYLOSUCCINIC ACID Suppliers

China 27 Germany 1 Switzerland 1 United Kingdom 1 United States 8 Global 38

3B Pharmachem (Wuhan) International Co.,Ltd.

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Syntechem Co.,Ltd

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Hangzhou Sage Chemical Co., Ltd.

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Sigma-Aldrich

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19046-78-7, ADENYLOSUCCINIC ACIDRelated Search:

Nicotinic acid B12 VITAMIN B12 Nicotinamide Octenyl succinate starch adenylosuccinic acid 2',3'-acyclic dialcohol adenylosuccinic acid-2',3'-acyclic dialdehyde 6-(BETA-HYDROXYETHYLAMINO)-PURINE ADENYLOSUCCINIC ACID SODIUM SALT,ADENYLOSUCCINIC ACID SODIUM ADENYLOSUCCINIC ACID (9H-PURIN-6-YLAMINO)ACETIC ACID

ADENYLOSUCCINIC ACID

ADENYLOSUCCINIC ACID HYDRATE

2-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]amino]butanedioic acid

Adenylsuccinic acid

adenylosuccnic acid

adenylosuccinic acid free acid

aspartyl adenylate

Aspartyl-AMP

L-Aspartic acid 4-(5'-adenylyl) ester

N-[9-(5-O-Phosphono-β-D-ribofuranosyl)-9H-purin-6-yl]-L-aspartic acid

C03794

L-Aspartic acid, N-[9-(5-O-phosphono-b-D-ribofuranosyl)-9H-purin-6-yl]-

(S)-2-((9-((2R,3R,4S,5R)-3,4-dihydroxy-5-((phosphonooxy)Methyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)aMino)succinic acid

L-Aspartic acid, N-[9-(5-O-phosphono-β-D-ribofuranosyl)-9H-purin-6-yl]-

19046-78-7

C14H18N5O11P

Chromogenic

Activity

Chromogenic

Enzyme Substrates

API