Introduction Efficacy and effect Pharmacological effects
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Crocin

Introduction Efficacy and effect Pharmacological effects
Product Name
Crocin
CAS No.
42553-65-1
Chemical Name
Crocin
Synonyms
GARDENIN;Crocin A;Crocins;Crocin 1;CROCETIN DIGENTIOBIOSYL ESTER;CROCIN;Crocin-Ⅰ;α-Crocin;CCRIS 7705;Crocin ,98%
CBNumber
CB2311935
Molecular Formula
C44H64O24
Formula Weight
976.97
MOL File
42553-65-1.mol
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Crocin Property

Melting point:
186° (effervescence)
Boiling point:
1169.0±65.0 °C(Predicted)
Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly, Heated), Methanol (Very Slightly, Sonicated)
form 
Powder
pka
12.20±0.70(Predicted)
color 
Orange to Very Dark Purple
Merck 
14,2589
Stability:
Light Sensitive
InChIKey
OXNHRKGZZFWUQZ-QORFUXSJSA-N
LogP
-4.742 (est)
CAS DataBase Reference
42553-65-1
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Safety

Safety Statements 
24/25
WGK Germany 
3
RTECS 
HL7380000
F 
1-8-10
HS Code 
32129000
Hazardous Substances Data
42553-65-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
17304
Product name
Crocin
Purity
for microscopy
Packaging
1g
Price
$58.4
Updated
2024/03/01
Sigma-Aldrich
Product number
PHL80391
Product name
Crocin
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$187
Updated
2024/03/01
Sigma-Aldrich
Product number
17304
Product name
Crocin
Purity
for microscopy
Packaging
5g
Price
$186
Updated
2024/03/01
TCI Chemical
Product number
C1527
Product name
Crocin (Gardenia Fruits Extract)
Packaging
25g
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
26337
Product name
Crocin/Gardenia Extract
Packaging
500mg
Price
$32
Updated
2024/03/01
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Crocin Chemical Properties,Usage,Production

Introduction

Crocin (crocin) is also known as a-crocin and crocetin. It is a series of ester glycosides combining water-soluble carotenoids crocetin and different sugars. It is one of the main active ingredients of saffron, including crocin -1, crocin -2, crocin -3, crocin-4 and crocetin.It is centrally acting antihypertensive and can prevent atherosclerosis and be of antithrombosis, antiplatelet aggregation, and anti myocardial ischemia.

Efficacy and effect

The traditional medicine believes that the stigma croci can dredge and activate the collaterals, remove blood stasis, eradicate depression and relieve swelling and pain. It is mainly used for the treatment of anxiety depression, chest distention, irregular menstruation, postpartum haemorrhage and traumatic injury. The main effective components are crocetin and crocin, which has many pharmacological activities, such as being anti-inflammatory and analgesic, antitumor, antidepressant, hypoglycemic and lowering blood pressure. Because the water solution of stigma croci is bright yellow with sweet smell, it is often used as a food additive and high-grade edible pigment, but also can be used as high dye for silk, cotton and wool products. In recent years, pharmacological researches indicate that stigma croci has good control effect for a variety of diseases, including cancer, coronary heart disease, atherosclerosis and hyperlipidemia.

Pharmacological effects

Crocin has the effect of the anti-inflammation and treatment of soft tissue injury, gall liver protection, anti-tumor and other pharmacological effects. It is widely used in food, medicine, chemical industry and other industries. It is used in the treatment of patients with cardiovascular disease and fatty liver.with good medicinal value.

Description

Crocin/Gardenia Extract is a Gardenia extract that contains crocin I, II, and III, and crocetin, among other compounds.

Chemical Properties

Crocin is a reddish brown needle-like crystal. Slightly odor. Easily soluble in hot water, becomes the orange solution. Slightly soluble in anhydrous ethanol, ether, and other organic solvents. Insoluble in oil. The aqueous solution is weakly acidic or neutral transparent bright yellow, with a maximum absorption wavelength of 442nm. color is almost unaffected by pH value. Light and heat resistance is good in neutral or alkaline, and poor in acidic. Metal ion resistance (except iron, blackened by iron) is good. The coloring of protein is better than that of starch and is not affected by pH (pH4-10).

Uses

Crocin, is a natural carotenoid derived the flowers crocus and gardenia. Crocin has been shown to be a potent antioxidant. It has also been shown to have an antiproliferative action against cancer cells in vitro, and also possessing possible antidepressant properties.

Definition

ChEBI: Crocin-1 is a diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters. It is one of the water-soluble yellow-red pigments of saffron and is used as a spice for flavouring and colouring food. Note that in India, the term 'Crocin' is also used by GlaxoSmithKline as a brand-name for paracetamol. It has a role as an antioxidant, a food colouring, a plant metabolite and a histological dye. It is a diester, a disaccharide derivative and a diterpenoid. It is functionally related to a beta-D-gentiobiosyl crocetin and a gentiobiose.

General Description

Crocin (CR) is a water-soluble carotenoid found in Gardenia jasmi-noides Ellis and Crocus sativus (saffron). It has two D-gentiobioside glycosyl esters in its structure. CR is one of the major bioactive compounds of saffron contributing to its red color. A highly unsaturared diterpene dicarboxylic acid ester found in saffron.

Biochem/physiol Actions

Crocin alleviates some ethanol-induced impairments of learning and prevents ethanol-induced inhibition of hippocampal long-term potentiation (LTP), a form of activity-dependent synaptic plasticity that may underly learning and memory. Related CNS effects are specific to the digentiobiose ester; crocetin glucose gentiobiose ester is half as potent, and the diglucose ester has no effect at all.

Crocin Preparation Products And Raw materials

Raw materials

Ethanol Pectin COREOPSISYELLOWEXTRACT

Preparation Products

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Crocin Suppliers

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View Lastest Price from Crocin manufacturers

Hebei Dangtong Import and export Co LTD
Product
CROCIN 42553-65-1
Price
US $3660.00-3600.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-03
Changsha Staherb Natural Ingredients Co., Ltd.
Product
Crocin; Saffron Extract; Gardenia Extract 42553-65-1
Price
US $0.00/KG
Min. Order
1KG
Purity
40%-99% HPLC
Supply Ability
1000KG
Release date
2022-09-16
BINBO BIOLOGICAL CO.,LTD
Product
Crocin 42553-65-1
Price
US $0.00/kg
Min. Order
1kg
Purity
40% 50% 55% 95%
Supply Ability
1000 kg
Release date
2024-04-26

42553-65-1, CrocinRelated Search:

Croci Stigma Crocin 2 BUTYL-BETA-D-GLUCOPYRANOSIDE 2,3-DIHYDROXYPROPYL METHACRYLATE ETHYL SORBATE N-HEXYL ACRYLATE PROPYL-CROTONATE 4-Hydroxybutyl acrylate Sorbic acid 4-HYDROXYBUTYL METHACRYLATE Butyl methacrylate trans,trans-2,4-Heptadienal FEMA 3354 3-ALLYLOXY-1,2-PROPANEDIOL Diethylene glycol monobutyl ether 2-HYDROXYPROPYL ACRYLATE 2,6-DIMETHYL-2,4,6-OCTATRIENE 2,3-DIHYDROXYPROPYL ACRYLATE

  • saffron(natural)
  • ucopyranosyl)ester
  • Crocin ,98%
  • CrocinⅡ ,98%
  • Crocin ,96%
  • Crocin,Crocetin digentiobiose ester
  • Crocetin digentiobioside
  • Crocin 1
  • Crocin A
  • (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-Tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioic acid bis(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) ester
  • 8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid bis(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) ester
  • 8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid bis[6-O-β-D-glucopyranosyl-β-D-glucopyranosyl] ester
  • trans-Crocetin di(β-D-gentiobiosyl) ester
  • Crocin, froM Crocus sativus
  • Crocin for microscopy
  • Saffron, HARLECO?
  • Crocin Crocetin digentibiose ester
  • Crocin - microscopy grade
  • b-D-Glucopyranose, 6-O-b-D-glucopyranosyl-,1,1'-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate
  • Crocin/Gardenia Extract
  • Crocin (gardenia fruit
  • bis(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl) 8,8'-diapo-psi,psi-carotenedioate
  • CROCIN:B-D-GLUCOPYRANOSE, 6-O--D-GLUCOPYRANOSYL-, 1,1'-[(ALL-E)-2,6,11,15-TETRAMETHYL-2,4,6,8,10,12,14-HEXADECAHEPTAENEDIOATE],
  • crocetin digentibiose ester
  • bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate
  • CROCIN(CRUDE)(RG)
  • Crocin (Gardenia Fruits Extract)
  • β-D-Glucopyranose, 6-O-β-D-glucopyranosyl-,1,1'-[(all-E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]
  • Crocetin digentibiose ester, Crocin
  • BETA-D-GLUCOPYRANOSE, 6-O-BETA-D-GLUCOPYRANOSYL-, 1,1'-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-TETRAMETHYL-2,4,6,8,10,12,14-HEXADECAHEPTAENEDIOATE]
  • B-D-GLUCOPYRANOSE, 6-O-BETA-D-GLUCOPYRANOSYL-, 1,1'-[(ALL-E)-2,6,11,15-TETRAMETHYL-2,4,6,8,10,12,14-HEXADECAHEPTAENEDIOATE]
  • GARDENIN
  • CROCETIN BIS(GENTIOBIOSYL) ESTER
  • CROCETIN DIGENTIOBIOSYL ESTER
  • CROCIN
  • CROCIN GARDENIA FRUIT EXTRACT
  • Crocin-Ⅰ
  • ALPHA-CROCIN
  • 8,8’-Diapo-4,4-carotenedioicacidbis(6-O-D-glucopyranosyl-D-glucopyranosyl)ester
  • 8,8’-diapo-psi,psi-carotenedioicacid,bis(6-o-beta-d-glucopyranosyl-beta-d-gl
  • Di-gentiobiose ester
  • Crocin, from gardenia fruits
  • Crocins
  • β-D-Glucopyranose, 6-O-β-D-glucopyranosyl-, 1,1'-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]
  • (2E,4E,6E,8E,10E,12E,14E)-Bis((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl) 2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate
  • CROCIN USP/EP/BP
  • α-Crocin
  • CROCIN 42553-65-1
  • CCRIS 7705
  • Crocin (Gardenia Fruits Extract)（42553651）,Crocin (Gardenia Fruits Extract)（42553 65 1）
  • Endogenous Metabolite,Crocin I,Crocin,inhibit,Inhibitor
  • Tibetan bonus T
  • 42553-65-1
  • C44H64O24
  • C46H68O23
  • BioChemical
  • Biochemicals and Reagents
  • Natural Dyes