TRX-0237 mesylate

Product Name: TRX-0237 mesylate
CAS No.: 1236208-20-0
Chemical Name: TRX-0237 mesylate
Synonyms: Hydromethylthionine mesylate;CS-2892;Leucomethylene;RX-0237 mesylate;TRX-0237 mesylate;TRx0237 (LMTX) mesylate;TRX0237 (LMTX) , (CH3SO3H);Leucomethylene blue (Mesylate);Leucomethylene Blue Dimesylate;Leucomethylene blue Mesylate, >98%
CBNumber: CB23119756
Molecular Formula: C16H19N3S.2(CH4O3S)
Formula Weight: 477.61848
MOL File: 1236208-20-0.mol

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TRX-0237 mesylate Property

storage temp.: Store at -20°C
solubility: DMSO:102.5(Max Conc. mg/mL);214.61(Max Conc. mM)
H2O:54.0(Max Conc. mg/mL);113.06(Max Conc. mM)
form: A solid
color: Light green to green

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Crysdot

Product number: CD11319607
Product name: LeucomethyleneBlueMesylate
Purity: 97%
Packaging: 5mg
Price: $40
Updated: 2021/12/16

CSNpharm

Product number: CSN17257
Product name: LeucomethyleneBlueMesylate
Packaging: 5mg
Price: $48
Updated: 2021/12/16

Crysdot

Product number: CD11319607
Product name: LeucomethyleneBlueMesylate
Purity: 97%
Packaging: 10mg
Price: $55
Updated: 2021/12/16

Crysdot

Product number: CD11319607
Product name: LeucomethyleneBlueMesylate
Purity: 97%
Packaging: 50mg
Price: $173
Updated: 2021/12/16

DC Chemicals

Product number: DC10217
Product name: TRx0237(LMTX)mesylate
Purity: >98%
Packaging: 100mg
Price: $250
Updated: 2021/12/16

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TRX-0237 mesylate Chemical Properties,Usage,Production

Biological Activity

TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor. For the treatment of Alzheimer's disease and frontotemporal dementia.

in vitro

TRx 0237 (LMTX?) is a second-generation tau aggregation inhibitor for the treatment of Alzheimer's disease and frontotemporal dementia. It is a purified form of methylene blue, an ancient drug widely used in Africa to treat malaria and methemoglobinemia. In vitro experiments demonstrated that 0.16 μM TRx 0237 interfered with double helical filaments (PHF) isolated from Alzheimer's disease patient brain tissue.

in vivo

TRX-0237 mesylate dose-dependently rescues learning impairment in L1 (a mouse strain overexpressing truncated tau protein) and restores its behavioral resilience in the water maze test (minimum dose administered: 9 mg MT/kg). In L66 (a mouse strain overexpressing full-length tau-P301S/G335D), it modulates its motor learning (effective dose: 4 mg MT/kg). It reduced the number of tau-active neurons, especially in the hippocampus and entorhinal cortex of L1, and more generally in the L66 strain.

target

Target	Value
tau protein aggregation

TRX-0237 mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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TRX-0237 mesylate Suppliers

China 61 United States 9 Global 70

Changzhou Chenhong Biotechnology Co., Ltd.

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MedChemexpress LLC

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Shanghai SuperLan Chemcial Technique Centre

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View Lastest Price from TRX-0237 mesylate manufacturers

Career Henan Chemica Co

Product: CH3SO3H 1236208-20-0
Price: US $0.01/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1kg; 5kg; 10kg
Release date: 2020-10-28

1236208-20-0, TRX-0237 mesylateRelated Search:

Leucomethylene blue (Mesylate)

N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine methanesulfonate (1:2)

TRX0237 (LMTX) , (CH3SO3H)

TRx0237 (LMTX) mesylate

TRX-0237 mesylate

CS-2892

Leucomethylene blue Mesylate, >98%

METHYLENE BLUE LEUCO BASE MESYLATE SALT, >98%

Hydromethylthionine mesylate

Leucomethylene

N3,N3,N7,N7-tetramethyl-10H-Phenothiazine-3,7-diamine, methanesulfonate

Leucomethylene Blue Dimesylate

Methylene blue leuco base mesylate salt

TRx-0237,Methylene blue leuco base,Aβ25-35,aggregation,Tau,Inhibitor,inhibit,Leucomethylene blue mesylate,β-amyloid peptide,Amyloid-β,Disease,Leucomethylene blue,TRx0237,TRx 0237,Alzheimer's,Abeta

RX-0237 mesylate

N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine dimethanesulfonate

1236208-20-0

C16H19N3S2CH4O3S