4-ethynylpyridin-2-amine
- Product Name
- 4-ethynylpyridin-2-amine
- CAS No.
- 1094679-27-2
- Chemical Name
- 4-ethynylpyridin-2-amine
- Synonyms
- 4-Ethynyl-2-pyridinamine;4-ethynylpyridin-2-amine;2-Pyridinamine, 4-ethynyl-;4-Ethynyl-pyridin-2-ylamine
- CBNumber
- CB23121405
- Molecular Formula
- C7H6N2
- Formula Weight
- 118.14
- MOL File
- 1094679-27-2.mol
4-ethynylpyridin-2-amine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Light brown to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0059695
- Product name
- 4-Ethynylpyridin-2-amine
- Packaging
- 100mg
- Price
- $203
- Updated
- 2021/12/16
- Product number
- CS-0059695
- Product name
- 4-Ethynylpyridin-2-amine
- Packaging
- 250mg
- Price
- $338
- Updated
- 2021/12/16
- Product number
- E16539
- Product name
- 4-ethynylpyridin-2-amine
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- 2671AQ
- Product name
- 4-ethynylpyridin-2-amine
- Packaging
- 1g
- Price
- $892.4
- Updated
- 2021/12/16
- Product number
- E16539
- Product name
- 4-ethynylpyridin-2-amine
- Purity
- 97.0%
- Packaging
- 5g
- Price
- $1560
- Updated
- 2021/12/16
4-ethynylpyridin-2-amine Chemical Properties,Usage,Production
Synthesis
84249-14-9
1066-54-2
1094679-27-2
Using 2-amino-4-bromopyridine (400 mg, 2.31 mmol) and trimethylsilylacetylene (0.38 mL, 2.77 mmol), bis(benzylcarbonitrile)dichloropalladium (II) was prepared in the presence of cesium carbonate (39.1 mg, 0.12 mmol) and 4,5-bis(diphenylphosphino)-9,9-dimethylx-ton (69.4 mg, 0.12 mmol). Palladium(II) chloride (46.0 mg, 0.12 mmol) was dissolved in DMF (5 mL). Subsequently, triethylamine (2 mL) was added and the reaction mixture was stirred at 50 °C in an oil bath for 2 hours. Upon completion of the reaction, THF (3 mL) and tetrabutylammonium fluoride (2.77 mL) were added, the solvent was concentrated under reduced pressure, and then the reaction was continued for 30 min at room temperature. Finally, the solvent was evaporated and the residue was purified by silica gel column chromatography using a solvent mixture of chloroform and methanol (1:50) as eluent to afford the target product 4-ethynylpyridin-2-amine (90.1 mg, 33% yield).
References
[1] Patent: JP2015/221769, 2015, A. Location in patent: Paragraph 0031; 0033
4-ethynylpyridin-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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