ChemicalBook > CAS DataBase List > genz-682452

genz-682452

Product Name
genz-682452
CAS No.
1401090-53-6
Chemical Name
genz-682452
Synonyms
GZ-452;CS-2780;GZ402671;GZ-402671;SAR402671;Ibiglustat;SAR 402671;SAR-402671;genz-682452;GZ/SAR402671
CBNumber
CB23121975
Molecular Formula
C20H24FN3O2S
Formula Weight
389.49
MOL File
1401090-53-6.mol
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genz-682452 Property

Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:37.5(Max Conc. mg/mL);96.28(Max Conc. mM)
form 
A crystalline solid
pka
10.34±0.46(Predicted)
color 
White to off-white
InChI
InChI=1S/C20H24FN3O2S/c1-20(2,17-12-27-18(22-17)14-3-5-15(21)6-4-14)23-19(25)26-16-11-24-9-7-13(16)8-10-24/h3-6,12-13,16H,7-11H2,1-2H3,(H,23,25)/t16-/m1/s1
InChIKey
YFHRCLAKZBDRHN-MRXNPFEDSA-N
SMILES
C(O[C@H]1C2CCN(CC2)C1)(=O)NC(C1=CSC(C2=CC=C(F)C=C2)=N1)(C)C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301IF SWALLOWED:

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Crysdot
Product number
CD11264912
Product name
Ibiglustat
Purity
97%
Packaging
50mg
Price
$366
Updated
2021/12/16
DC Chemicals
Product number
DC10007
Product name
Ibiglustat(Genz-682452）
Purity
>98%
Packaging
250mg
Price
$950
Updated
2021/12/16
Crysdot
Product number
CD11264912
Product name
Ibiglustat
Purity
97%
Packaging
250mg
Price
$1100
Updated
2021/12/16
DC Chemicals
Product number
DC10007
Product name
Ibiglustat(Genz-682452）
Purity
>98%
Packaging
1g
Price
$1800
Updated
2021/12/16
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genz-682452 Chemical Properties,Usage,Production

Uses

Ibiglustat (Venglustat) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease[1][2].

References

[1] Viel C, et al. Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model. Sci Rep. 2021;11(1):20945. Published 2021 Oct 22. DOI:10.1038/s41598-021-00404-5
[2] Peterschmitt MJ, et al. Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral Venglustat in Healthy Volunteers. Clin Pharmacol Drug Dev. 2021;10(1):86-98. DOI:10.1002/cpdd.865
[3] Stojkovska I, et al. Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease. Cell Tissue Res. 2018;373(1):51-60. doi:10.1007/s00441-017-2704-y DOI:10.1007/s00441-017-2704-y
[4] Itier JM, et al. Effective clearance of GL-3 in a human iPSC-derived cardiomyocyte model of Fabry disease. J Inherit Metab Dis. 2014 Nov;37(6):1013-22. DOI:10.1007/s10545-014-9724-5

genz-682452 Preparation Products And Raw materials

Raw materials

Preparation Products

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genz-682452 Suppliers

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1401090-53-6, genz-682452Related Search:

Eliglustat Genz644282

  • GZ/SAR402671
  • IBIGLUSTAT;VENGLUSTAT;GZ/SAR402671;GZ402671;SAR402671
  • genz-682452
  • Ansofaxine Hydrochloride
  • Ibiglustat
  • (S)-QUINUCLIDIN-3-YL (2-(2-(4-FLUOROPHENYL)THIAZOL-4-YL)PROPAN-2-YL)CARBAMATE
  • Ibiglustat(Genz-682452)
  • Genz-682452-AA
  • GZ402671
  • GZ-402671
  • GZ-402671; GZ402671; GZ402671; SAR402671; SAR-402671; SAR 402671; GENZ-682452-AA; IBIGLUSTAT; GZ-452; GENZ-682452
  • GZ-452
  • CS-2780
  • SAR 402671
  • SAR402671
  • SAR-402671
  • Carbamic acid, N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]-, (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
  • Ibiglustat (Venglustat
  • oral,Parkinson's disease,GZ-402671,GZ 402671,Ibiglustat,inhibit,Inhibitor,SAR 402671,SAR-402671,GBA,Fabry disease,GL-3 levels,mutations
  • Venglustat (ibiglustat)
  • Ibiglustat, 10 mM in DMSO
  • 1401090-53-6
  • API