2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
- Product Name
- 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
- CAS No.
- 1609394-10-6
- Chemical Name
- 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
- Synonyms
- 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)benzenamine;Benzenamine, 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)-;EOS-61512;Deucravacitinib Impurity 8;BMS-986165 Related Compound 3;2-Methoxy-3-(1-methyl-1,2,4-triazol-3-YL)aniline;2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline;2-Methoxy-3-(1-methyl-1H-[1,2,4]triazol-3-yl)-phenylamine
- CBNumber
- CB23122644
- Molecular Formula
- C10H12N4O
- Formula Weight
- 204.23
- MOL File
- 1609394-10-6.mol
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Property
- Boiling point:
- 437.6±55.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- solubility
- DMSO (Slightly)
- pka
- 3.45±0.10(Predicted)
- form
- Solid
- color
- Pale Orange to Brown
- InChI
- InChI=1S/C10H12N4O/c1-14-6-12-10(13-14)7-4-3-5-8(11)9(7)15-2/h3-6H,11H2,1-2H3
- InChIKey
- FIAZRZSVFOMYSD-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=CC(C2N=CN(C)N=2)=C1OC
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P311Call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 3076EB
- Product name
- 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
- Packaging
- 1g
- Price
- $1283
- Updated
- 2021/12/16
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Chemical Properties,Usage,Production
Chemical Properties
white solid
Uses
2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline is used in the preparation of pyridazines which is a heterodimeric cytokines modulators for treatment of diseases.
Synthesis
To a high pressure reactor flushed with nitrogen were charged methanol (8.0 kg/kg) and Compound 6 (1.0 kg). With careful exclusion of oxygen, sodium bicarbonate (0.6 kg/kg, 2.0 equiv.) and Pd/C (10% loading, 50 % wet, 0.02 kg/kg) were added. The reactor was pressurized with hydrogen (41-46 psi), and the reaction mixture was aged at 20 °C for 6 h then heated to 45 °C and aged till reaction reached completion. The reactor was flushed with nitrogen, and the reaction crude was filtered to remove Pd/C. Methanol (5 kg/kg) was used to aid the transfer. The combined filtrates were distilled under vacuum until total volume became approximately 2.5 L/kg. Water (10 kg/kg) was added, and the crude was distilled under vacuum until total volume became approximately 2.5 L/kg. The crude was heated to 70 °C. Brine (25 wt%, 9.0 kg/kg) was added, and the resulting crude was agitated for 6 h at 70 °C. After cooling down to 0 °C, the crude was further aged for 6 h. Product was isolated by filtration. The cake was washed with brine (pre-cooled to 0 °C, 25 wt%, 2.0 kg/kg), and dried under vacuum at 45 °C. 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline was isolated in 99 AP and 88% yield.
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline manufacturers
- Product
- 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline 1609394-10-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 500KG
- Release date
- 2023-04-18
- Product
- 2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline 1609394-10-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 50kg
- Release date
- 2023-09-12
- Product
- 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline 1609394-10-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%
- Supply Ability
- 20 tons
- Release date
- 2023-07-03