Acelarin

Product Name: Acelarin
CAS No.: 840506-29-8
Chemical Name: Acelarin
Synonyms: CPF-31);NUC-1031;Acelarin;NUC-1031 impurity;Acelarin（NUC1031）;NUC-1031 (Acelarin);Acelarin, 10 mM in DMSO;NUC-1031; NUC1031; NUC 1031;DNA/RNA Synthesis,NUC 1031,Acelarin,Inhibitor,inhibit,NUC1031;N-(2'-Deoxy-2',2'-difluoro-P-phenyl-5'-cytidylyl)-L-alanine phenylmethyl ester
CBNumber: CB23126662
Molecular Formula: C25H27F2N4O8P
Formula Weight: 580.47
MOL File: 840506-29-8.mol

More

Less

Acelarin Property

Boiling point:: 708.4±70.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 12 mg/mL; DMSO: 14 mg/mL; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL; Ethanol: 10 mg/mL
form: A crystalline solid
pka: 11.46±0.70(Predicted)
color: White to off-white
InChIKey: NHTKGYOMICWFQZ-KKQYNPQSSA-N

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 9003247
Product name: NUC-1031
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 9003247
Product name: NUC-1031
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 9003247
Product name: NUC-1031
Packaging: 5mg
Price: $161
Updated: 2024/03/01

ChemScene

Product number: CS-6147
Product name: Acelarin
Purity: 99.76%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND158438
Product name: N-(2'-Deoxy-?2',?2'-?difluorocytidine 5'-P-?phenyl phosphate) L-?alanine? benzyl ester
Packaging: 2mg
Price: $250
Updated: 2021/12/16

More

Less

Acelarin Chemical Properties,Usage,Production

Uses

Acelarin is a phosphoramidate transformation of the pancreatic and ovarian cancer chemotherapy Gemcitabine; and the first anti-cancer ProTide to enter the clinic.

in vivo

The ProTide demonstrates a significant reduction in tumor size against pancreatic xenograft models compared with the gemcitabine treated group, and less adverse effects on body weight, indicating a better safety profile. Data strongly suggests that the ProTides are not reliant on kinases or nucleoside transporters to exert their activity inside tumor cells and remain stable in the presence of deaminases. The ProTide NUC-1031 is currently advancing through phase I/II clinical studies and has already generated strong pharmacokinetic data that confirm significantly higher intracellular levels of gemcitabine triphosphate, together with promising early efficacy signals and a favorable safety profile. The phosphoramidate chemistry is potentially a great source of new and very effective anticancer agents, bringing a considerable array of advanced treatments specifically designed to overcome cancer resistance mechanisms that will benefit a greater proportion of patients^[1].

Acelarin Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Acelarin Suppliers

China 68 United Kingdom 1 United States 7 Global 76

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Lianyungang TengFa Biological Technology Co. Ltd

Tel: 0518-85475186 18705131893
Fax: 0518-85475186
Email: wang666xt@163.com
Country: China
ProdList: 351
Advantage: 55

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1853
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Zhengzhou Huiju Chemical Co., Ltd.

Tel: 0371-55900031 18137872243
Fax: QQ：2853979815
Email: 2853979815@qq.com
Country: China
ProdList: 9975
Advantage: 55

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

More

Less

View Lastest Price from Acelarin manufacturers

Career Henan Chemical Co

Product: Acelarin 840506-29-8
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 1kg; 10kg; 25kg
Release date: 2020-01-07

840506-29-8, AcelarinRelated Search:

PRND FORMANILIDE

Acelarin

N-(2'-Deoxy-2',2'-difluoro-P-phenyl-5'-cytidylyl)-L-alanine phenylmethyl ester

NUC-1031

NUC-1031 impurity

N-(2'-Deoxy-2',2'-difluorocytidine 5'-P-phenyl phosphate) L-alanine benzyl ester

NUC-1031; NUC1031; NUC 1031

L-Alanine, N-(2'-deoxy-2',2'-difluoro-P-phenyl-5'-cytidylyl)-, phenylmethyl ester

Acelarin（NUC1031）

(2S)-Benzyl 2-(((((2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

DNA/RNA Synthesis,NUC 1031,Acelarin,Inhibitor,inhibit,NUC1031

NUC-1031 (Acelarin)

Acelarin, 10 mM in DMSO

CPF-31)

840506-29-8

C25H27F2N4O8P