BMS-582949 (hydrochloride)

Product Name: BMS-582949 (hydrochloride)
CAS No.: 912806-16-7
Chemical Name: BMS-582949 (hydrochloride)
Synonyms: BMS-582949 (hydrochloride);BMS 582949,BMS 582949 hydrochloride,Inhibitor,BMS582949,Autophagy,BMS-582949,inhibit,BMS582949 hydrochloride,p38 MAPK
CBNumber: CB23126697
Molecular Formula: C22H27ClN6O2
Formula Weight: 442.94178
MOL File: 912806-16-7.mol

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BMS-582949 (hydrochloride) Property

storage temp.: Store at -20°C
solubility: ≥44.3 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥2.7 mg/mL in EtOH with gentle warming and ultrasonic
form: solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B7850
Product name: BMS-582949hydrochloride
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-5621
Product name: BMS-582949hydrochloride
Purity: 98.82%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

Apolloscientific

Product number: BISN0242
Product name: BMS-582949hydrochloride
Packaging: 5mg
Price: $203
Updated: 2021/12/16

ChemScene

Product number: CS-5621
Product name: BMS-582949hydrochloride
Purity: 98.82%
Packaging: 25mg
Price: $500
Updated: 2021/12/16

Apolloscientific

Product number: BISN0242
Product name: BMS-582949hydrochloride
Packaging: 25mg
Price: $682
Updated: 2021/12/16

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BMS-582949 (hydrochloride) Chemical Properties,Usage,Production

Biological Activity

bms-582949 hydrochloride is a novel, potent and highly selective p38α mitogen-activated protein kinase (p38α mapk) inhibitor [1].the p38α map kinase plays a critical role in regulating the production of many inflammatory cytokines, including tnf-α and il-1β. excessive production of tnf-α and il-1β has been implicated in many inflammatory diseases [1].bms-582949 hydrochloride potently inhibited the activity of p38α mapk with the ic50 value of 13 nm [1]. bms-582949 showed no significant effects on cytochrome p450 isozymes 1a2, 2c9, 2c19, and 2d6 with the ic50 values of >40 μm. bms-582949 weakly inhibited the activity of cyp3a4, with the ic50 value of 18-40 μm. bms-582949 displayed >2000-fold selectivity for p38α over a diverse panel of 57 kinases, include serine kinases, receptor tyrosine kinases, nonreceptor tyrosine kinases, and the p38γ and δ isoforms. bms-582949 showed 450-fold selectivity over jnk2, a map kinase involved in inflammation, and 190-fold selective over raf [1]. in mice, after oral administration of bms-582949 (10 mg/kg), the clearance rate for bms-582949 is 4.4 ml/min/kg. bms-582949 exhibited oral bioavailability values of 90% and 60% in mice and rats, respectively [1].bms-582949 is currently under phase ii

References

[1] liu c, lin j, wrobleski s t, et al. discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-n-propylpyrrolo [1, 2-f][1, 2, 4] triazine-6-carboxamide (bms-582949), a clinical p38α map kinase inhibitor for the treatment of inflammatory diseases[j]. journal of medicinal chemistry, 2010, 53(18): 6629-6639.
[2] emami h, vucic e, subramanian s, et al. the effect of bms-582949, a p38 mitogen-activated protein kinase (p38 mapk) inhibitor on arterial inflammation: a multicenter fdg-pet trial[j]. atherosclerosis, 2015, 240(2): 490-496.

BMS-582949 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-582949 (hydrochloride) Suppliers

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912806-16-7, BMS-582949 (hydrochloride)Related Search:

BMS-582949 (hydrochloride)

BMS 582949,BMS 582949 hydrochloride,Inhibitor,BMS582949,Autophagy,BMS-582949,inhibit,BMS582949 hydrochloride,p38 MAPK

912806-16-7

C22H27ClN6O2