(4-Chloro-2-methoxy-phenyl)-hydrazine hydrochloride
- Product Name
- (4-Chloro-2-methoxy-phenyl)-hydrazine hydrochloride
- CAS No.
- 1567373-49-2
- Chemical Name
- (4-Chloro-2-methoxy-phenyl)-hydrazine hydrochloride
- Synonyms
- (4-CHLORO-2-METHOXYPHENYL)HYDRAZINE HCL;(4-Chloro-2-methoxy-phenyl)-hydrazine hydrochloride;Hydrazine, (4-chloro-2-methoxyphenyl)-, hydrochloride (1:1)
- CBNumber
- CB23128545
- Molecular Formula
- C7H10Cl2N2O
- Formula Weight
- 209.07
- MOL File
- 1567373-49-2.mol
(4-Chloro-2-methoxy-phenyl)-hydrazine hydrochloride Property
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Methanol
- form
- Solid
- color
- Grey
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AK607786
- Product name
- (4-Chloro-2-methoxyphenyl)hydrazinehydrochloride
- Purity
- 97%
- Packaging
- 100mg
- Price
- $67
- Updated
- 2021/12/16
- Product number
- A261496
- Product name
- (4-Chloro-2-methoxyphenyl)hydrazinehydrochloride
- Purity
- 97%
- Packaging
- 100mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- CD12137704
- Product name
- (4-Chloro-2-methoxyphenyl)hydrazinehydrochloride
- Purity
- 97%
- Packaging
- 100mg
- Price
- $69
- Updated
- 2021/12/16
- Product number
- A261496
- Product name
- (4-Chloro-2-methoxyphenyl)hydrazinehydrochloride
- Purity
- 97%
- Packaging
- 250mg
- Price
- $92
- Updated
- 2021/12/16
- Product number
- CD12137704
- Product name
- (4-Chloro-2-methoxyphenyl)hydrazinehydrochloride
- Purity
- 97%
- Packaging
- 250mg
- Price
- $111
- Updated
- 2021/12/16
(4-Chloro-2-methoxy-phenyl)-hydrazine hydrochloride Chemical Properties,Usage,Production
Uses
(4-Chloro-2-methoxy-phenyl)-hydrazine Hydrochloride is an intermediate in the synthesis of 1-(4-Chloro-2-hydroxyphenyl)-1,2-dihydro-3H-pyrazol-3-one (C423995), a Pyraclostrobin (P840400) related compound and intermediate in preparation of hydroxylated derivatives of Pyraclostrobin.
Synthesis
93-50-5
1567373-49-2
The general procedure for the synthesis of (4-chloro-2-methoxyphenyl)hydrazine hydrochloride from 4-chloro-2-methoxyaniline is as follows: 4-chloro-2-methoxyaniline (1.69 g, 10.7 mmol, 1 eq.) was suspended in a mixture of concentrated hydrochloric acid (25 mL) and acetic acid (10 mL) at 0 °C. A solution of sodium nitrite (740 mg, 10.7 mmol, 1 equiv) in water (10 mL) was added slowly and dropwise. The reaction mixture was gradually warmed to 60 °C and maintained at this temperature for 1.5 hours. Subsequently, the reaction solution was cooled to 0 °C and a concentrated hydrochloric acid (25 mL) solution of stannous chloride (5.32 g, 23.6 mmol, 2.2 equiv) was added. After 30 min of reaction, the precipitate was collected by filtration to afford the target product (4-chloro-2-methoxyphenyl)hydrazine hydrochloride (2.06 g, 93% yield). The product was characterized by 1H NMR (DMSO-d6): δ 9.94 (br.s, 2H), 7.72 (br.s, 1H), 7.07 (s, 1H), 7.00 (s, 2H), 3.85 (s, 3H). With reference to the above method, other intermediates of similar structure can be prepared by substituting appropriate reagents, raw materials and purification methods.
References
[1] Patent: WO2014/28805, 2014, A1. Location in patent: Page/Page column 65; 66
(4-Chloro-2-methoxy-phenyl)-hydrazine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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