ChemicalBook > CAS DataBase List > (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
- Product Name
- (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
- CAS No.
- 1448297-52-6
- Chemical Name
- (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
- Synonyms
- 133776;CPD1584;MDK-7526;VH032-NH2;PROTAC-VHL-ligand;MDK7526(free base);(S,R,S)-AHPC (MDK7526);PROTACs Related Compound 1;VH032-NH2|||MDK7526|||VHL ligand 1;(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy- N-(
- CBNumber
- CB23134090
- Molecular Formula
- C22H30N4O3S
- Formula Weight
- 430.56
- MOL File
- 1448297-52-6.mol
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(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Property
- Boiling point:
- 691.6±55.0 °C(Predicted)
- Density
- 1.254±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 14.10±0.40(Predicted)
- form
- Solid
- color
- White to light yellow
- InChIKey
- ZLOXMSNKPDWMEF-ZIFCJYIRSA-N
- SMILES
- C(NCC1=CC=C(C2SC=NC=2C)C=C1)(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)(C)C)N
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Biorbyt Ltd
- Product number
- orb573171
- Product name
- MDK7526
- Purity
- >98%
- Packaging
- 500mg
- Price
- $615.4
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb573171
- Product name
- MDK7526
- Purity
- >98%
- Packaging
- 1g
- Price
- $1133.9
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb573171
- Product name
- MDK7526
- Purity
- >98%
- Packaging
- 2g
- Price
- $2023
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 153556
- Product name
- (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
- Purity
- 95%
- Packaging
- 5g
- Price
- $2900
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 153556
- Product name
- (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
- Purity
- 95%
- Packaging
- 10g
- Price
- $4700
- Updated
- 2021/12/16
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(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Chemical Properties,Usage,Production
Definition
(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
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