ChemicalBook > CAS DataBase List > [4-(4-METHYLPIPERAZINO)PHENYL]METHANOL

[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL

Product Name
[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL
CAS No.
342405-34-9
Chemical Name
[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL
Synonyms
BUTTPARK 98\50-53;RARECHEM AL BD 1090;4-(4-METHYLPIPERAZINO)BENZYL ALCOHOL;[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL;4-(4-N-Methylpiperazinyl)benzyl alcohol;4-(4-Methylpiperazin-1-yl)benzyl alcohol;4-(4-Methyl-1-piperazinyl)benzenemethanol;[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]METHANOL;Benzenemethanol, 4-(4-methyl-1-piperazinyl)-;(4-(4-Methylpiperazin-1-yl)phenyl)methanol - [M89622]
CBNumber
CB2313742
Molecular Formula
C12H18N2O
Formula Weight
206.28
MOL File
342405-34-9.mol
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[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL Property

Melting point:
118-120°C
Boiling point:
363.7±42.0 °C(Predicted)
Density 
1.105±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
15.05±0.10(Predicted)
Appearance
White to light yellow Solid
Odor
almond nutty
LogP
0.135 (est)
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Safety

Hazard Codes 
Xi
Risk Statements 
34-36/37/38
Safety Statements 
26-36/37/39
RIDADR 
1759
HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
M219220
Product name
4-(4-Methylpiperazino)benzylAlcohol
Packaging
10mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR23310
Product name
4-(4-Methylpiperazin-1-yl)benzylalcohol
Packaging
250mg
Price
$15
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-XR
Product name
4-(4-Methylpiperazin-1-yl)benzyl alcohol
Packaging
250mg
Price
$16
Updated
2021/12/16
Apolloscientific
Product number
OR23310
Product name
4-(4-Methylpiperazin-1-yl)benzylalcohol
Packaging
1g
Price
$18
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-XR
Product name
4-(4-Methylpiperazin-1-yl)benzyl alcohol
Packaging
1g
Price
$20
Updated
2021/12/16
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[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL Chemical Properties,Usage,Production

Synthesis

197638-83-8

342405-34-9

General procedure for the synthesis of 4-(4-methylpiperazine)benzyl alcohol from 1-BOC-4-(4-formylphenyl)piperazine: tert-butyl 4-(4-formylphenyl)-piperazine-1-carboxylate (1.3 g, 4.47 mmol) was dissolved in THF (50 mL), lithium aluminium hydroxide (LAH, 0.7 g, 17.87 mmol) was added with stirring and refluxing at 37 °C for for 14 hours. After completion of the reaction, the reaction was quenched with 14 N aqueous KOH (20 mL) at room temperature. The supernatant was separated, combined with the DCM wash solution and diluted with water (50 mL). The mixture was extracted with DCM (3 x 50 mL), the organic phases were combined and concentrated by rotary evaporator to give [4-(4-methylpiperazin-1-yl)phenyl]methanol (0.82 g, 89% yield). DMSO (0.56 mL, 7.96 mmol) was dissolved in DCM (50 mL), oxalyl chloride (0.7 mL, 7.96 mmol) was added and stirred at -78 °C for 0.5 h. The mixture was then dissolved in DCM (50 mL). A solution of [4-(4-methylpiperazin-1-yl)phenyl]methanol (0.82 g, 3.98 mmol) in DCM (20 mL) was added slowly and stirring was continued for 1.5 hours at -78 °C. Triethylamine (1.7 mL, 11.94 mmol) was added to gradually warm the reaction mixture to room temperature. After stirring for 4 h, the reaction was quenched with 1 N aqueous sodium bicarbonate (50 mL). The mixture was extracted with DCM (3 x 50 mL), the organic phases were combined and concentrated to give a residue, which was purified by column chromatography to give 4-(4-methylpiperazin-1-yl)benzaldehyde (0.5 g). Further, 5,7-dimethoxy-2-(4-(4-methylpiperazin-1-yl)phenyl)quinazolin-4(3H)-one (120 mg, 41% yield) was converted to its hydrochloride salt (yellow solid). Characterization data: MS (m/z): 381.11; melting point 252.4-254.2 °C (dihydrochloride).

References

[1] Patent: US2008/188467, 2008, A1. Location in patent: Page/Page column 38-39
[2] Patent: US2013/281397, 2013, A1. Location in patent: Paragraph 0522; 0523

[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL Suppliers

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View Lastest Price from [4-(4-METHYLPIPERAZINO)PHENYL]METHANOL manufacturers

Career Henan Chemical Co
Product
[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL 342405-34-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

342405-34-9, [4-(4-METHYLPIPERAZINO)PHENYL]METHANOLRelated Search:

4-(4-METHYLPIPERAZINO)-3-NITROBENZENECARBOXYLIC ACID METHYL 3-NITRO-4-[4-(4-NITROPHENYL)PIPERAZINO]BENZENECARBOXYLATE METHYL 4-(4-METHYLPIPERAZIN-1-YL)BENZOATE [5-amino-2-(4-methylpiperazino)phenyl]methanol METHYL 4-[4-(3,4-DICHLOROBENZOYL)PIPERAZINO]-3-NITROBENZENECARBOXYLATE METHYL 4-[4-(4-CHLOROPHENYL)PIPERAZINO]-3-NITROBENZENECARBOXYLATE METHYL 4-(4-BENZHYDRYLPIPERAZINO)-3-NITROBENZENECARBOXYLATE METHYL 4-(4-[2-(4-FLUOROPHENYL)-2-OXOETHYL]PIPERAZINO)-3-NITROBENZENECARBOXYLATE METHYL 4-[4-(4-FLUOROPHENYL)PIPERAZINO]-3-NITROBENZENECARBOXYLATE METHYL 3-NITRO-4-[4-(2-PYRIDINYL)PIPERAZINO]BENZENECARBOXYLATE METHYL 4-[4-(4-IODOBENZOYL)PIPERAZINO]-3-NITROBENZENECARBOXYLATE 4-[4-(4-CHLOROBENZYL)PIPERAZINO]-3-NITROBENZENECARBOXYLIC ACID 4-[4-(4-CHLOROPHENYL)PIPERAZINO]-3-NITROBENZENECARBOXYLIC ACID METHYL 4-[4-(3,4-DICHLOROPHENYL)PIPERAZINO]-3-NITROBENZENECARBOXYLATE METHYL 3-NITRO-4-[4-(3-NITRO-2-PYRIDINYL)PIPERAZINO]BENZENECARBOXYLATE METHYL 3-NITRO-4-(4-[2-(3-NITROPHENYL)-2-OXOETHYL]PIPERAZINO)BENZENECARBOXYLATE METHYL 4-[4-(4-METHOXYBENZOYL)PIPERAZINO]-3-NITROBENZENECARBOXYLATE 4-[1-(2-HYDROXYETHYL)PIPERAZINO]-3,5-DINITROBENZOIC ACID

  • 4-(4-Methylpiperazin-1-yl)benzyl alcohol
  • [4-(4-METHYLPIPERAZINO)PHENYL]METHANOL
  • [4-(4-METHYLPIPERAZIN-1-YL)PHENYL]METHANOL
  • 4-(4-METHYLPIPERAZINO)BENZYL ALCOHOL
  • BUTTPARK 98\50-53
  • RARECHEM AL BD 1090
  • 4-(4-N-Methylpiperazinyl)benzyl alcohol
  • Benzenemethanol, 4-(4-methyl-1-piperazinyl)-
  • 4-(4-Methyl-1-piperazinyl)benzenemethanol
  • (4-(4-Methylpiperazin-1-yl)phenyl)methanol - [M89622]
  • 342405-34-9
  • Alcohols and Derivatives
  • Heterocycles