Val-Cit-PAB-MMAE

Product Name: Val-Cit-PAB-MMAE
CAS No.: 644981-35-1
Chemical Name: Val-Cit-PAB-MMAE
Synonyms: VCPMMAE;Val-Cit-PAB-MMAE;Val-Cit-PAB-MMAE, 10 mM in DMSO;4H-1-Benzopyran-4-one,7-hydroxy-4-(trifluoromethyl)-;Drug-Linker Conjugates for ADC,inhibit,Inhibitor,Val Cit PAB MMAE,ValCitPABMMAE;N-Methyl-N-[[[4-[[L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide;4-((S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate
CBNumber: CB23139525
Molecular Formula: C58H94N10O12
Formula Weight: 1123.42676
MOL File: 644981-35-1.mol

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Val-Cit-PAB-MMAE Property

storage temp.: -20°C
solubility: Soluble in DCM
form: Solid
color: White to off-white
InChIKey: WZEAGSMYTVSXQA-DQTLHWFHNA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23465
Product name: Val-Cit-PAB-MMAE
Purity: 95%
Packaging: 5mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-5780
Product name: Val-Cit-PAB-MMAE
Purity: 99.83%
Packaging: 10mg
Price: $760
Updated: 2021/12/16

BroadPharm

Product number: BP-23465
Product name: Val-Cit-PAB-MMAE
Purity: 95%
Packaging: 10mg
Price: $950
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611404
Product name: Val-Cit-PAB-MMAE
Packaging: 5mg
Price: $1030.2
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611404
Product name: Val-Cit-PAB-MMAE
Packaging: 10mg
Price: $1445
Updated: 2021/12/16

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Val-Cit-PAB-MMAE Chemical Properties,Usage,Production

Description

Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a a protease-sensitive Val-Cit dipeptide, and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells.

Uses

Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

IC 50

Auristatin

References

[1] Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897. DOI:10.1158/1078-0432.CCR-09-2069

Val-Cit-PAB-MMAE Preparation Products And Raw materials

Raw materials

Preparation Products

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Val-Cit-PAB-MMAE Suppliers

China 114 United States 7 Global 121

SuZhou JianHua Pharmaceutical Co. Ltd

Tel: 13666392288
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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
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Shanghai Topbiochem Technology Co., Ltd

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EnliPharma Technology Co., Ltd

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TargetMol Chemicals Inc.

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Tianjin Chempharmatech Co.,Ltd.

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ALB Technology Limited

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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai Changyan Chem & Tech Co., Ltd.

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Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
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ProdList: 5001
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View Lastest Price from Val-Cit-PAB-MMAE manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Val-Cit-PAB-MMAE 644981-35-1
Price: US $0.00/mg
Min. Order: 100mg
Purity: >98.00%
Supply Ability: 100mg
Release date: 2024-03-29

644981-35-1, Val-Cit-PAB-MMAERelated Search:

CITRININ

Val-Cit-PAB-MMAE

4H-1-Benzopyran-4-one,7-hydroxy-4-(trifluoromethyl)-

Drug-Linker Conjugates for ADC,inhibit,Inhibitor,Val Cit PAB MMAE,ValCitPABMMAE

4-((S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate

VCPMMAE

Val-Cit-PAB-MMAE, 10 mM in DMSO

N-Methyl-N-[[[4-[[L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide

644981-35-1

644981-35-2

ADCs

ADC LINKER