Val-Cit-PAB-MMAE

Product Name: Val-Cit-PAB-MMAE
CAS No.: 644981-35-1
Chemical Name: Val-Cit-PAB-MMAE
Synonyms: VCPMMAE;Val-Cit-PAB-MMAE;Val-Cit-PAB-MMAE, 10 mM in DMSO;4H-1-Benzopyran-4-one,7-hydroxy-4-(trifluoromethyl)-;Drug-Linker Conjugates for ADC,inhibit,Inhibitor,Val Cit PAB MMAE,ValCitPABMMAE;N-Methyl-N-[[[4-[[L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide;4-((S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate
CBNumber: CB23139525
Molecular Formula: C58H94N10O12
Formula Weight: 1123.42676
MOL File: 644981-35-1.mol

More

Less

Val-Cit-PAB-MMAE Property

storage temp.: -20°C
solubility: Soluble in DCM
form: Solid
color: White to off-white
InChIKey: WZEAGSMYTVSXQA-DQTLHWFHNA-N

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

BroadPharm

Product number: BP-23465
Product name: Val-Cit-PAB-MMAE
Purity: 95%
Packaging: 5mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-5780
Product name: Val-Cit-PAB-MMAE
Purity: 99.83%
Packaging: 10mg
Price: $760
Updated: 2021/12/16

BroadPharm

Product number: BP-23465
Product name: Val-Cit-PAB-MMAE
Purity: 95%
Packaging: 10mg
Price: $950
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611404
Product name: Val-Cit-PAB-MMAE
Packaging: 5mg
Price: $1030.2
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611404
Product name: Val-Cit-PAB-MMAE
Packaging: 10mg
Price: $1445
Updated: 2021/12/16

More

Less

Val-Cit-PAB-MMAE Chemical Properties,Usage,Production

Description

Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a a protease-sensitive Val-Cit dipeptide, and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells.

Uses

Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

IC 50

Auristatin

References

[1] Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897. DOI:10.1158/1078-0432.CCR-09-2069

Val-Cit-PAB-MMAE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Val-Cit-PAB-MMAE Suppliers

China 118 United States 7 Global 125

SuZhou JianHua Pharmaceutical Co. Ltd

Tel: 13666392288
Email: jhyylcj@163.com
Country: China
ProdList: 64
Advantage: 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16059
Advantage: 64

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9520
Advantage: 58

EnliPharma Technology Co., Ltd

Tel: 0551-66399836 18955197623
Email: sales@enlipharma.com
Country: China
ProdList: 1876
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 8000
Advantage: 58

Tianjin Chempharmatech Co.,Ltd.

Tel: 022-66211079 13212288319
Fax: qq1405432731
Email: sales@chempharmatech.com
Country: China
ProdList: 925
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

ALB Technology Limited

Tel: 702-983-3769
Fax: 702-983-3769
Email: sales@albtechnology.com
Country: United States
ProdList: 2993
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 89689
Advantage: 60

More

Less

View Lastest Price from Val-Cit-PAB-MMAE manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Val-Cit-PAB-MMAE 644981-35-1
Price: US $0.00/mg
Min. Order: 100mg
Purity: >98.00%
Supply Ability: 100mg
Release date: 2024-03-29

644981-35-1, Val-Cit-PAB-MMAERelated Search:

CITRININ

Val-Cit-PAB-MMAE

4H-1-Benzopyran-4-one,7-hydroxy-4-(trifluoromethyl)-

Drug-Linker Conjugates for ADC,inhibit,Inhibitor,Val Cit PAB MMAE,ValCitPABMMAE

4-((S)-2-((S)-2-Amino-3-methylbutanamido)-5-ureidopentanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate

VCPMMAE

Val-Cit-PAB-MMAE, 10 mM in DMSO

N-Methyl-N-[[[4-[[L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide

644981-35-1

644981-35-2

ADCs

ADC LINKER