ChemicalBook > CAS DataBase List > 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacid

4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacid

Product Name
4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacid
CAS No.
1644670-37-0
Chemical Name
4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacid
Synonyms
LNP023;LNP0233;EOS-62416;LNP023(LNP-023;4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacid;Benzoic acid, 4-[(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]-2-piperidinyl]-
CBNumber
CB23142721
Molecular Formula
C25H30N2O4
Formula Weight
422.52
MOL File
1644670-37-0.mol
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4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacid Property

Boiling point:
599.1±50.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:50.0(Max Conc. mg/mL);118.34(Max Conc. mM)
pka
4.07±0.10(Predicted)
form 
Solid
color 
Off-white to gray
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0093107
Product name
Iptacopan
Purity
98.66%
Packaging
5mg
Price
$400
Updated
2021/12/16
ChemScene
Product number
CS-0093107
Product name
Iptacopan
Purity
98.66%
Packaging
10mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0093107
Product name
Iptacopan
Purity
98.66%
Packaging
50mg
Price
$1900
Updated
2021/12/16
ChemScene
Product number
CS-0093107
Product name
Iptacopan
Purity
98.66%
Packaging
100mg
Price
$2900
Updated
2021/12/16
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4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacid Chemical Properties,Usage,Production

Biological Activity

Iptacopan (LNP023) is a first-in-class, potent, and orally active and highly selective factor B inhibitor with IC50 of 10 nM. Iptacopan binds factor B directly and reversibly with high affinity with a KD of 7.9 nM. Iptacopan targets the underlying cause of C3 glomerulopathy.

in vitro

Iptacopan (LNP023) demonstrates potent inhibition of alternative complement pathway (AP)-induced membrane attack complex (MAC) formation in 50% human serum (IC 50 value of 130 nM).
It exhibits excellent selectivity over other proteases affording IC 50 values of >30 μM across a panel of 41 human proteases, including the AP protein factor D (>100 μM) .

in vivo

Iptacopan (LNP023; 20-180 mg/kg; oral administration) prevents KRN (150 μL)-induced arthritis in mice and is effective upon prophylactic and therapeutic dosing in an experimental model of membranous nephropathy in rats. < br/> It exhibits moderate half-lives (T 1/2 ; Wistar Han rats 3.4 h, beagle dogs 5.5 h) and C max (Wistar Han rats 410 nM, beagle dogs 2200 nM) following oral administration (rat 30 and, dog 10 mg/kg).
Iptacopan exhibits terminal elimination half-lives (T 1/2 ; Wistar Han rats 7 h, beagle dogs 5.6 h) due to high plasma clearance (8, and 2 mL/min/kg respectively combined with large volumes of distribution (2.3, and 0.6 L/kg respectively) following intravenous administration (rat 1.0 and, dog 0.1 mg/kg respectively) ).

Animal Model: C57BL/6 mice with KRN-induced arthritis
Dosage: 20, 60, and 180 mg/kg
Administration: Orally gavaged; twice a day (bid) for 14 days
Result: Blocked KRN-induced arthritis.

target

KD: 7.9 nM (factor B)
IC50: 10 nM (factor B)

4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacid Suppliers

China 77 United States 4 Global 81
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-5032306 18917961636
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+86-556-5032307
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wtx@bayeebio.com
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China
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Shanghai Hope Chem Co., Ltd.，
Tel
+21-18501659228 18501659228
Fax
sales@hope-chem.com
Email
info@hope-chem.com
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China
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479
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Shanghai Hongboshangyi Pharmaceutical Technology Co. , Ltd.
Tel
021-58999902
Email
huangjiahui@prssh.com
Country
China
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2311
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Chunchuang (Wuhan) Technology Co., Ltd
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15342225168
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yutianchun2007@126.com
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China
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10003
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Wuhan Jingkangen Biomedical Technology Co., Ltd
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13720134139 13720134139
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orders@jknbiochem.com
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China
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5821
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Wuhan HSN Pharmaresearch CO., LTD.
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027-63499089 18086100502
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027-86589137
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linwell@126.com
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China
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211
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50
Nantong Hanfang Biotechnology Co. , Ltd.
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18616537568
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hanfangpharma@126.com
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China
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29971
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SINO High Goal Chemical Technology Co., Ltd.
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021-57646680 18306277365
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2469917557
Email
sunkai@chembiobanksh.com
Country
China
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2042
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185
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sales-cpd@caerulumpharma.com
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China
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3466
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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4573
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1644670-37-0, 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacidRelated Search:


  • 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoicacid
  • EOS-62416
  • LNP023
  • Benzoic acid, 4-[(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]-2-piperidinyl]-
  • LNP023(LNP-023
  • LNP0233
  • 1644670-37-0