NSC-12

Product Name: NSC-12
CAS No.: 102586-30-1
Chemical Name: NSC-12
Synonyms: CS-2338;CS-2161;NSC172285;NSC12，NSC 172285;NSC-12;NSC 12;NSC12;21-Norchol-5-ene-3,20,23-triol, 24,24,24-trifluoro-23-(trifluoromethyl)-, (3β,20S)-
CBNumber: CB23145540
Molecular Formula: C24H34F6O3
Formula Weight: 484.52
MOL File: 102586-30-1.mol

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NSC-12 Property

Boiling point:: 521.8±45.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
form: A crystalline solid
pka: 9.50±0.29(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20117
Product name: NSC 12
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20117
Product name: NSC 12
Purity: ≥98%
Packaging: 5mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 20117
Product name: NSC 12
Purity: ≥98%
Packaging: 10mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 20117
Product name: NSC 12
Purity: ≥98%
Packaging: 25mg
Price: $494
Updated: 2024/03/01

DC Chemicals

Product number: DC9945
Product name: NSC-12
Purity: >98%
Packaging: 250mg
Price: $1750
Updated: 2021/12/16

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NSC-12 Chemical Properties,Usage,Production

Biological Activity

NSC12 (NSC 172285) is an orally available inhibitor of FGF2/FGFR interaction with potential antitumor activity.

in vitro

NSC-12 can inhibit FGF-dependent tumor growth, angiogenesis and metastasis. It did not affect FGF2/heparin interaction, but inhibited FGF2 binding to immobilized receptors (IC50 ~30 μM), it disrupted FGF2 interaction with FGFR1, and had no effect on the interaction activity of growth factors with heparin or HSPGs .

in vivo

Administered by injection and oral route, NSC-12 inhibits FGFR activation, tumor growth, angiogenesis and metastasis in FGF-dependent mouse and human tumor models. In animal models, it significantly reduced tumor weight, tumor cell FGFR1 phosphorylation levels and proliferation, and tumor CD31+ cardiovascular formation.

target

Target	Value
FGF3 (Cell-free assay)	15.9 μM(Kd)
FGF8b (Cell-free assay)	18.9 μM(Kd)
FGF22 (Cell-free assay)	26.8 μM(Kd)
FGF20 (Cell-free assay)	29.4 μM(Kd)
FGF2/FGFR (Cell-free assay)	30 μM

NSC-12 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC-12 Suppliers

China 32 United States 5 Global 37

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102586-30-1, NSC-12Related Search:

NSC-12;NSC 12;NSC12

CS-2161

CS-2338

21-Norchol-5-ene-3,20,23-triol, 24,24,24-trifluoro-23-(trifluoromethyl)-, (3β,20S)-

NSC12，NSC 172285

NSC172285

102586-30-1

C24H34F6O3