488793-85-7
- Product Name
- 488793-85-7
- CAS No.
- 488793-85-7
- Chemical Name
- 488793-85-7
- Synonyms
- ARN272;ARN-272
- CBNumber
- CB23145843
- Molecular Formula
- C27H20N4O2
- Formula Weight
- 432.47
- MOL File
- 488793-85-7.mol
488793-85-7 Property
- Boiling point:
- 629.1±55.0 °C(Predicted)
- Density
- 1.357±0.06 g/cm3(Predicted)
- pka
- 8.56±0.30(Predicted)
N-Bromosuccinimide Price
- Product number
- 11244
- Product name
- ARN272
- Packaging
- 1mg
- Price
- $36
- Updated
- 2021/12/16
- Product number
- 11244
- Product name
- ARN272
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 11244
- Product name
- ARN272
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- Axon 2941
- Product name
- ARN 272
- Purity
- 98%
- Packaging
- 25mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- Axon 2941
- Product name
- ARN 272
- Purity
- 98%
- Packaging
- 2x25mg
- Price
- $550
- Updated
- 2021/12/16
488793-85-7 Chemical Properties,Usage,Production
Uses
ARN 272 is a a competitive antagonist of the interaction of anandamide with FAAH-like anandamide transporter (FLAT), that lacks amidase activity but binds anandamide with low micromolar affinity and facilitates its translocation into cells.
Enzyme inhibitor
This FLAT inhibitor (FW = 432.47 g/mol; CAS 488793-85-7), also named 4-[[4-(4-hydroxy-phenyl)-1-phthalazinyl]amino]-N-phenylbenzamide, targets the FAAH-Like Anandamide Transporter (IC50 = 1.8 μM), a catalytically silent variant of fatty acid amide hydrolase-1 (FAAH-1) that drives anandamide transport. Mode of Action: The intensity and duration of anandamide signaling appear to be controlled by a two-step elimination process, in which the anandamide or an anandamide-like substance is first internalized by neurons and astrocytes through the action of FLAT and then undergoes hydrolysis through the action of the intracellular membrane- bound amidases, FAAH-1 and FAAH-2. ARN-272 attenuates anandamide internalization, thereby reducing its deactivation. ARN272 competitively antagonizes [ 3 H]-anandamide binding to FLAT (IC50 = 1.8 μM) and inhibits [ 3 H]-anandamide accumulation in both FLAT-expressing Hek293 cells (IC50 ≈ 3 μM) and primary cultures of cortical neurons prepared from rats or wild-type mice. By contrast, ARN272 is without significant effect on the residual [ 3 H]-anandamide accumulation observed in cortical transport system may also facilitate the release of this lipid mediator from cells It also exhibits analgesic effects in rodent models of CB1 endocannabinoid receptor-mediated nociceptive and inflammatory pain.
488793-85-7 Preparation Products And Raw materials
Raw materials
Preparation Products
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