ChemicalBook > CAS DataBase List > HSF1A

HSF1A

Product Name: HSF1A
CAS No.: 1196723-93-9
Chemical Name: HSF1A
Synonyms: HSF1A;HSF1A ，S0294;HSF1 Activator;CAS 1196723-93-9;HSF1 Activator HSF1A;HSF1A, 10 mM in DMSO;HSF1 ACTIVATOR;HSF1A;CAS 1196723-93-9;Inhibitor,HSP,inhibit,Heat shock proteins,HSF1A,HSF-1A;4-Ethyl-N-[1-phenyl-3-(2-thienyl)-5-pyrazolyl]benzenesulfonamide;Benzenesulfonamide, 4-ethyl-N-[1-phenyl-3-(2-thienyl)-1H-pyrazol-5-yl]-
CBNumber: CB23146305
Molecular Formula: C21H19N3O2S2
Formula Weight: 409.52
MOL File: 1196723-93-9.mol

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HSF1A Property

Boiling point:: 592.6±60.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:116.0(Max Conc. mg/mL);283.26(Max Conc. mM)
form: Solid
pka: 6.53±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-7837
Product name: HSF1A
Purity: 99.43%
Packaging: 2mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-7837
Product name: HSF1A
Purity: 99.43%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-7837
Product name: HSF1A
Purity: 99.43%
Packaging: 10mg
Price: $264
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0017260
Product name: HSF-1A
Purity: 95.00%
Packaging: 5MG
Price: $504.17
Updated: 2021/12/16

ChemScene

Product number: CS-7837
Product name: HSF1A
Purity: 99.43%
Packaging: 25mg
Price: $588
Updated: 2021/12/16

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HSF1A Chemical Properties,Usage,Production

Uses

HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1)[1]. HSF1A also acts as a specific inhibitor of TRiC/CCT. Chaperonin TCP-1 ring complex (TRiC)/chaperonin containing TCP-1 (CCT) plays a pivotal role in toxin translocation and/or refolding[4].

Biological Activity

Cell permeable: yes', 'Primary Target
HSF1

in vivo

HSF1A enhances HSF1 activity, stabilizes HSF1 expression and minimizes Doxorubicin (DOX)-induced cardiac damage. WKY rats are challenged with DOX (accumulated dose: 30 mg/kgw), and DOX combined with HSF1A (100 mg/kgw/day). Supplementation with HSF1A significantly elevates cardiac functions back to the levels of the control group. HSF1A has been shown to stimulate human HSF1 nuclear translocation, elevate protein chaperone expression and ameliorate protein misfolding and cell death in a neurodegenerative disease model. The echocardiographic results show that HSF1A also alleviates DOX-induced failures in cardiac function^[3].

IC 50

HSF1

References

[1] Neef DW, et al. A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. Cell Rep. 2014 Nov 6;9(3):955-66. DOI:10.1016/j.celrep.2014.09.056
[2] Neef DW, et al. Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. PLoS Biol. 2010 Jan 19;8(1):e1000291. DOI:10.1371/journal.pbio.1000291
[3] Huang CY, et al. Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death. Cell Death Dis. 2016 Nov 3;7(11):e2455. DOI:10.1038/cddis.2016.356
[4] Marcus Steinemann, et al. The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9580-9585. DOI:10.1073/pnas.1807658115

HSF1A Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from HSF1A manufacturers

Career Henan Chemical Co

Product: HSF1A 1196723-93-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-24

1196723-93-9, HSF1ARelated Search:

CALCISEPTINE

HSF1A

HSF1 ACTIVATOR;HSF1A;CAS 1196723-93-9

CAS 1196723-93-9

HSF1 Activator

Benzenesulfonamide, 4-ethyl-N-[1-phenyl-3-(2-thienyl)-1H-pyrazol-5-yl]-

4-Ethyl-N-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-5-yl)benzenesulfonamide

Inhibitor,HSP,inhibit,Heat shock proteins,HSF1A,HSF-1A

HSF1A, 10 mM in DMSO

HSF1 Activator HSF1A

4-Ethyl-N-[1-phenyl-3-(2-thienyl)-5-pyrazolyl]benzenesulfonamide

HSF1A ，S0294

1196723-93-9

API