ChemicalBook > CAS DataBase List > KPT-8602

KPT-8602

Product Name: KPT-8602
CAS No.: 1642300-52-4
Chemical Name: KPT-8602
Synonyms: CS-2388;ATG-016;ONO-7706;KPT-8602;Eltanexor;CAS:1642300-52-4;KPT-8602 (KPT 8602;Eltanexor (KPT-8602;Eltanexor, 10 mM in DMSO;Eltanexor (KPT-8602) ，S8397
CBNumber: CB23151727
Molecular Formula: C17H10F6N6O
Formula Weight: 428.3
MOL File: 1642300-52-4.mol

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KPT-8602 Property

Boiling point:: 574.4±60.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 13.06±0.50(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb611488
Product name: Eltanexor
Packaging: 5mg
Price: $430.1
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611488
Product name: Eltanexor
Packaging: 50mg
Price: $1149.2
Updated: 2021/12/16

DC Chemicals

Product number: DC22589
Product name: Eltanexor
Purity: >98%
Packaging: 5mg
Price: $208
Updated: 2021/12/16

DC Chemicals

Product number: DC22589
Product name: Eltanexor
Purity: >98%
Packaging: 10mg
Price: $280
Updated: 2021/12/16

DC Chemicals

Product number: DC22589
Product name: Eltanexor
Purity: >98%
Packaging: 50mg
Price: $760
Updated: 2021/12/16

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KPT-8602 Chemical Properties,Usage,Production

Uses

(αE)?-α-?[[3-?[3,?5-?bis(Trifluoromethyl)?phenyl]?-?1H-?1,?2,?4-?triazol-?1-?yl]?methylene]?-?5-pyrimidineacetamide is an exportin-1 inhibitor with anti-leukemic activity. Exportin-1 mediates nuclear trafficking of proteins. (αE)?-α-?[[3-?[3,?5-?bis(Trifluoromethyl)?phenyl]?-?1H-?1,?2,?4-?triazol-?1-?yl]?methylene]?-?5-pyrimidineacetamide can be used to develop treatments for acute lymphoblastic leukemia.

in vivo

KPT-8602 (15 mg/kg; oral gavage; daily for 12 days) shows potent anti-lymphoblastic leukemia activity^[1].

Animal Model:	Female BALB/c mice (model with the JAK3 (M511I) mutation)^[1]
Dosage:	15 mg/kg
Administration:	Oral gavage; daily for 12 days
Result:	Showed a marked reduction in total white blood cell (WBC) counts after 2 days of treatment compared to placebo-treated animals and the WBC counts continued to drop until they reached normal levels (<10,000 cells/μL) by day 12.

KPT-8602 Preparation Products And Raw materials

Raw materials

Preparation Products

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KPT-8602 Suppliers

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1642300-52-4, KPT-8602Related Search:

KPT-8602

Eltanexor (KPT-8602

CS-2388

KPT-8602 (KPT 8602

Eltanexor

5-Pyrimidineacetamide, α-[[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]methylene]-, (αE)-

(E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-2-(pyrimidin-5-yl)acrylamide

ATG-016

ONO-7706

Eltanexor, 10 mM in DMSO

Eltanexor (KPT-8602) ，S8397

CAS:1642300-52-4

1642300-52-4