AEM1

Product Name: AEM1
CAS No.: 1030123-90-0
Chemical Name: AEM1
Synonyms: AEM1 >=98% (HPLC);AEM1, 10 mM in DMSO;AEM1 (NRF2 inhibitor AEM1);AEM-1,AEM1,inhibit,AEM 1,Inhibitor,Keap1-Nrf2;N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;Thieno[2,3-d]pyrimidin-4-amine, N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-;N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;N-[(2H-1,3-benzodioxol-5-yl)methyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;1-(2H-1,3-benzodioxol-5-yl)-N-[5-(4-fluorophenyl)-1H,4H-thieno[2,3-d]pyrimidin-4-ylidene]methanamine
CBNumber: CB23152537
Molecular Formula: C20H14FN3O2S
Formula Weight: 379.41
MOL File: 1030123-90-0.mol

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AEM1 Property

Boiling point:: 582.1±50.0 °C(Predicted)
Density: 1.457±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL; DMSO: 20 mg/mL; Ethanol: 0.25 mg/mL
form: A crystalline solid
pka: 5.04±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18321
Product name: AEM1
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18321
Product name: AEM1
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 18321
Product name: AEM1
Purity: ≥98%
Packaging: 500μg
Price: $35
Updated: 2021/12/16

Cayman Chemical

Product number: 18321
Product name: AEM1
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

TRC

Product number: B206920
Product name: N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
Packaging: 500g
Price: $50
Updated: 2021/12/16

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AEM1 Chemical Properties,Usage,Production

Uses

N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine Inhibits deregulated NRF2 transcriptional activity in cancer.

Biological Activity

AEM1 (ARE expression modulator 1) is also a selective inhibitor of sirtuin 2, which is a protein deacetylase mediated by NAD+. Sirtuin 2 supports tumor cell proliferation, thus its inhibition stimulates cell death in tumors.', 'AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity. AEM1 broadly decreases the expression of NRF2 controlled genes and sensitizes A549 cells to various chemotherapeutic agents.

AEM1 Preparation Products And Raw materials

Raw materials

Preparation Products

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AEM1 Suppliers

Canada 2 China 39 United States 5 Global 46

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4573
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2998
Advantage: 58

Henan Alfachem Co.,Ltd.

Tel: 0371-0371-55051623 18137891487
Fax: QQ：2853979817
Email: 2853979817@qq.com
Country: China
ProdList: 9953
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30236
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3600
Advantage: 58

1030123-90-0, AEM1Related Search:

N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine

N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine

AEM1 (NRF2 inhibitor AEM1)

Thieno[2,3-d]pyrimidin-4-amine, N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-

AEM1 >=98% (HPLC)

AEM-1,AEM1,inhibit,AEM 1,Inhibitor,Keap1-Nrf2

1-(2H-1,3-benzodioxol-5-yl)-N-[5-(4-fluorophenyl)-1H,4H-thieno[2,3-d]pyrimidin-4-ylidene]methanamine

N-[(2H-1,3-benzodioxol-5-yl)methyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine

AEM1, 10 mM in DMSO

1030123-90-0