AEM1

Product Name: AEM1
CAS No.: 1030123-90-0
Chemical Name: AEM1
Synonyms: AEM1 >=98% (HPLC);AEM1, 10 mM in DMSO;AEM1 (NRF2 inhibitor AEM1);AEM-1,AEM1,inhibit,AEM 1,Inhibitor,Keap1-Nrf2;N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;Thieno[2,3-d]pyrimidin-4-amine, N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-;N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;N-[(2H-1,3-benzodioxol-5-yl)methyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;1-(2H-1,3-benzodioxol-5-yl)-N-[5-(4-fluorophenyl)-1H,4H-thieno[2,3-d]pyrimidin-4-ylidene]methanamine
CBNumber: CB23152537
Molecular Formula: C20H14FN3O2S
Formula Weight: 379.41
MOL File: 1030123-90-0.mol

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AEM1 Property

Boiling point:: 582.1±50.0 °C(Predicted)
Density: 1.457±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL; DMSO: 20 mg/mL; Ethanol: 0.25 mg/mL
form: A crystalline solid
pka: 5.04±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1556
Product name: AEM1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $94.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1556
Product name: AEM1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $380
Updated: 2025/07/31

Cayman Chemical

Product number: 18321
Product name: AEM1
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18321
Product name: AEM1
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 18321
Product name: AEM1
Purity: ≥98%
Packaging: 500μg
Price: $35
Updated: 2021/12/16

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AEM1 Chemical Properties,Usage,Production

Uses

N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine Inhibits deregulated NRF2 transcriptional activity in cancer.

Biological Activity

AEM1 (ARE expression modulator 1) is also a selective inhibitor of sirtuin 2, which is a protein deacetylase mediated by NAD+. Sirtuin 2 supports tumor cell proliferation, thus its inhibition stimulates cell death in tumors.', 'AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity. AEM1 broadly decreases the expression of NRF2 controlled genes and sensitizes A549 cells to various chemotherapeutic agents.

AEM1 Preparation Products And Raw materials

Raw materials

Preparation Products

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AEM1 Suppliers

Canada 2 China 45 United States 6 Global 53

BOC Sciences

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TargetMol Chemicals Inc.

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Career Henan Chemica Co

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1030123-90-0, AEM1Related Search:

N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine

N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine

AEM1 (NRF2 inhibitor AEM1)

Thieno[2,3-d]pyrimidin-4-amine, N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-

AEM1 >=98% (HPLC)

AEM-1,AEM1,inhibit,AEM 1,Inhibitor,Keap1-Nrf2

1-(2H-1,3-benzodioxol-5-yl)-N-[5-(4-fluorophenyl)-1H,4H-thieno[2,3-d]pyrimidin-4-ylidene]methanamine

N-[(2H-1,3-benzodioxol-5-yl)methyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine

AEM1, 10 mM in DMSO

1030123-90-0