galacto-Dapagliflozin

Product Name: galacto-Dapagliflozin
CAS No.: 1408245-02-2
Chemical Name: galacto-Dapagliflozin
Synonyms: galacto-Dapagliflozin;JVHXJTBJCFBINQ-IFLJBQAJSA-N;Dapagliflozin Galacto Isomer;(1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-galactitol;D-Galactitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-
CBNumber: CB23152618
Molecular Formula: C21H25ClO6
Formula Weight: 408.87
MOL File: 1408245-02-2.mol

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galacto-Dapagliflozin Property

storage temp.: Store at -20°C
solubility: ≤30mg/ml in DMSO;50mg/ml in dimethyl formamide
form: crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15952
Product name: galacto-Dapagliflozin
Purity: ≥95%
Packaging: 1mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 15952
Product name: galacto-Dapagliflozin
Purity: ≥95%
Packaging: 5mg
Price: $149
Updated: 2024/03/01

Cayman Chemical

Product number: 15952
Product name: galacto-Dapagliflozin
Purity: ≥95%
Packaging: 10mg
Price: $241
Updated: 2024/03/01

Cayman Chemical

Product number: 15952
Product name: galacto-Dapagliflozin
Purity: ≥95%
Packaging: 50mg
Price: $1068
Updated: 2024/03/01

AK Scientific

Product number: 5837EH
Product name: (2S,3R,4R,5R,6R)-2-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
Packaging: 50mg
Price: $1288
Updated: 2021/12/16

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galacto-Dapagliflozin Chemical Properties,Usage,Production

Biological Activity

ki = 2 nmgalacto-dapagliflozin is a potent inhibitor of human sglt2.renal glucose transport is mediated by sodium-glucose cotransporters (sglt) 1 and 2. in humans, sglt2 is responsible for the majority of glucose reabsorption in the kidney.

in vitro

it was found that galacto-dapagliflozin was a selective inhibitor of hsglt2, but was less potent than dapagliflozin for both transporters. both phlorizin and galacto-dapagliflozin rapidly dissociated from sglt2, while dapagliflozin and fluoro-dapagliflozin dissociated from hsglt2 at a rate 10-fold slower. dapagliflozin, fluoro-dapagliflozin, and galacto-dapagliflozin dissociated quickly from hsglt1, and phlorizin readily exchanged with dapagliflozin bound to hsglt1 [1].

in vivo

male db/db mice were administered dapagliflozin for 12 weeks. results showed that administration of dapagliflozin could ameliorate hyperglycemia, β-cell damage and albuminuria in db/db mice. serum creatinine, creatinine clearance and blood pressure were not affected by administration of dapagliflozin. dapagliflozin treatment was able to decrease macrophage infiltration in the kidney of db/db mice [2].

References

[1] hummel, c. s.,lu, c.,liu, j., et al. structural selectivity of human sglt inhibitors. american journal of physiology.cell physiology 302(2), c373-c382 (2012).
[2] terami n et al. long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice. plos one. 2014 jun 24;9(6):e100777.
[3] merovci a et al. dapagliflozin lowers plasma glucose concentration and improves β-cell function. j clin endocrinol metab. 2015 may;100(5):1927-32.

galacto-Dapagliflozin Preparation Products And Raw materials

Raw materials

Preparation Products

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galacto-Dapagliflozin Suppliers

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1408245-02-2, galacto-DapagliflozinRelated Search:

galacto-Dapagliflozin

JVHXJTBJCFBINQ-IFLJBQAJSA-N

D-Galactitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-

Dapagliflozin Galacto Isomer

(1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-galactitol

1408245-02-2